J Schölmerich

Approaches to Integrating Biomarkers Into Clinical Trials and Care Pathways as Targets for the Treatment of Inflammatory Bowel Diseases

Parambir S. Dulai, Laurent Peyrin‐Biroulet, Silvio Danese, Bruce E. Sands et autres

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Necrotizing tuberculosis with duodenal perforation as a primary manifestation of AIDS

Janine Hartl, Judith Maier, Martin Caselitz, Bernd Salzberger et autres

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Serum BAFF strongly correlates with PsA activity in male patients only--is there a role for sex hormones?

Georg Pongratz, Rainer Hans Straub, J Schölmerich, Marcelo Pio de Almeida Fleck et autres

OBJECTIVES: To determine the relationship between serum levels of B cell activating factor belonging to the TNF family (BAFF) and disease activity (DAS28) in psoriatic arthritis (PsA) patients. METHODS: Twenty-two male and 31 female psoriasis patients fulfilling the CASPAR criteria for PsA …

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Outcome of patients with ischemic-like cholangiopathy with secondary sclerosing cholangitis after liver transplantation

Gabi I. Kirchner, Marcus Nils Scherer, Aiman H. Obed, Petra Ruemmele et autres

BACKGROUND AND AIMS: Sclerosing cholangitis in critically ill patients (SC-CIP) with sepsis and acute respiratory distress syndrome (ARDS) is a cholestatic liver disease with a rapid progression to liver cirrhosis and hepatic failure. Data on outcome of these patients after liver transplantation …

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Splanchnic sympathectomy prevents translocation and spreading of E coli but not S aureus in liver cirrhosis

Michael Worlicek, Kathy D. Knebel, H.‐J. Linde, L Moleda et autres

INTRODUCTION: Spontaneous bacterial peritonitis (SBP) is mainly caused by bacterial translocation of enteric Gram-negative bacteria, predominantly Escherichia coli. The sympathetic nervous system (SNS) is activated in advanced cirrhosis, particularly in the splanchic circulation, and exerts potent immunosuppressive actions. However, the role of …

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Toll-Like Receptor Ligands Cause Proinflammatory and Prodiabetic Activation of Adipocytes via Phosphorylation of Extracellular Signal-Regulated Kinase and c-Jun N-Terminal Kinase But Not Interferon Regulatory Factor-3

Andrea Kopp, Christa Buechler, Margarita Bala, Markus Neumeier et autres

Here, we aim to investigate the mechanisms of Toll-like receptor (TLR)-induced prodiabetic and proinflammatory activation of adipocytes and to detect differences in the responsiveness of TLRs to their respective ligands between adipocytes isolated from inflamed vs. noninflamed adipose tissue. Experiments using specific …

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Alterations in mechanical properties of mesenteric resistance arteries in experimental portal hypertension

Markus Resch, Reiner Wiest, L Moleda, Sabine Fredersdorf et autres

Splanchnic vasodilation is the pathophysiological hallmark in the development of the hyperdynamic circulatory syndrome in liver cirrhosis and portal hypertension. This has been attributed so far mainly to a marked vascular hyporeactivity to endogenous vasoconstrictors. However, myogenic tone and vessel stiffness have …

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Immunsuppression – zu stark oder zu schwach?

Arne Schneidewind, Martin Fleck, Bernd Salzberger, J Schölmerich et autres

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Severe and long lasting cholestasis after high-dose co-trimoxazole treatment for Pneumocystis pneumonia in HIV-infected patients—a report of two cases

Frank Hanses, S. Zierhut, J Schölmerich, Bernd Salzberger et autres

Pneumocystis pneumonia (PCP), a common opportunistic infection in HIV-infected individuals, is generally treated with high doses of co-trimoxazole. However, treatment is often limited by adverse effects. Here, we report two cases of severely immunocompromised HIV-infected patients who developed severe intrahepatic cholestasis, and …

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Diagnostische und therapeutische Konsequenz von Ultraschallbefunden

D Schacherer, Adrian Schütz, Christiane Girlich, J Schölmerich et autres

Hintergrund und Fragestellung: Ziel der Studie war es, zu evaluieren welche diagnostischen und therapeutischen Konsequenzen aus den Ultraschallbefunden unserer Klinik gezogen wurden. Patienten und Methodik: Zwischen Anfang März 2004 und Ende Februar 2005 wurden im interdisziplinären Ultraschallzentrum der Universität Regensburg insgesamt 14 …

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Innate Immunity and Adipocyte Function: Ligand‐specific Activation of Multiple Toll‐like Receptors Modulates Cytokine, Adipokine, and Chemokine Secretion in Adipocytes

Andrea Kopp, Christa Buechler, Markus Neumeier, Johanna Weigert et autres

The aim of this study was to analyze Toll-like receptor (TLR) expression in preadipocytes and mature adipocytes and to investigate whether TLR ligands influence the release of cytokines, chemokines, and adipokines. Murine 3T3-L1 preadipocytes and mature adipocytes were used for stimulation experiments. …

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Transabdominal Ultrasound with Echoenhancement by Contrast Media in the Diagnosis of Hepatocellular Carcinoma

Doris Schacherer, Christiane Girlich, Michael E. Jung, Reiner Wiest et autres

According to the European Association for the Study of the Liver (EASL) and the American Association for the Study of Liver Diseases (AASLD), ultrasound (US) is the recommended tool for surveillance of patients at risk of developing hepatocellular carcinoma (HCC). Larger HCCs …

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