Kathy D. Knebel

Splanchnic sympathectomy prevents translocation and spreading of E coli but not S aureus in liver cirrhosis

Michael Worlicek, Kathy D. Knebel, H.‐J. Linde, L Moleda et autres

INTRODUCTION: Spontaneous bacterial peritonitis (SBP) is mainly caused by bacterial translocation of enteric Gram-negative bacteria, predominantly Escherichia coli. The sympathetic nervous system (SNS) is activated in advanced cirrhosis, particularly in the splanchic circulation, and exerts potent immunosuppressive actions. However, the role of …

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Systemic spreading of intraperitoneal Staphylococcus aureus is increased in experimental liver cirrhosis but unaltered by splanchnic sympathectomy

Kathy D. Knebel, Michael Worlicek, HJ Linde, L Moleda et autres

In liver cirrhosis, nosocomial spontaneous bacterial peritonitis (SBP) is associated with poor prognosis and most frequently caused by gram-positive bacteria. We previously reported that the well-known hyperactivity of the sympathetic nervous system (SNS) in advanced cirrhosis contributes to the translocation of E. …

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Splanchnic sympathectomy prevents translocation and spreading of E.coli in experimental liver cirrhosis

Roland Wiest, Michael Worlicek, H.‐J. Linde, Kathy D. Knebel et autres

Bacterial translocation (BT) of enteric gram-negative bacteria, predominantly E. coli frequently cause spontaneous infections in cirrhosis. The splanchnic sympathetic nervous system (SNS) is intensively activated in advanced cirrhosis and exerts potent immunosuppressive actions. However, the role of splanchnic SNS-activity for BT and …

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Binding Characteristics of the Antiendotoxin Antibody Xomen-E5 to Bacterial Whole-Cell Antigens

Kenneth J. Gorelick, David Michael Wood, J B Parent, Eric Teik Chung Lim et autres

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Human antibody responses to components of the monoclonal antimelanoma antibody ricin A chain immunotoxin XomaZyme-MEL.

Ronald P. Mischak, C Foxall, L.L. Rosendorf, Kathy D. Knebel et autres

Human antibody responses to immunotoxin components were evaluated in 21 melanoma patients who were treated with XomaZyme-MEL, a murine monoclonal antimelanoma antibody-ricin A chain conjugate. Twenty of the 21 melanoma patients produced antibodies against ricin A chain, while 15 of 21 produced …

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Clonogenicity of multiple populations of human glioma cells in vitro sorted by DNA content

Takao Hoshino, Kathy D. Knebel, Mark L. Rosenblum, Dolores V. Dougherty et autres

Malignant human gliomas have a highly variable distribution of cell nuclei, consisting of diploid and/or other populations in terms of nuclear DNA content. In order to study in vitro clonogenicity of each population, dissociated or cultured human glioma cells were stained with …

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Recovery from potentially lethal damage induced by spirohydantoin mustard on 9L cells in vitro.

M Bertrand, Deen Df, Takao Hoshino, Kathy D. Knebel

Spirohydantoin mustard (SHM) has been shown to cross the blood-brain barrier in dogs and has shown activity against mouse brian tumors in vivo and against 9L rat brain tumor cells in vitro. Factors influencing the recovery of monolayer 9L cells from SHM-induced …

Development of a 9L Rat Brain Tumor Cell Multicellular Spheroid System and Its Response to 1,3-Bis(2-chloroethyl)-1-nitrosourea and Radiation2

Dennis F. Deen, Takao Hoshino, Mary Elizabeth Williams, Isao Muraoka et autres

Rat brain tumor cells (9L cells) were cultured in suspension as multicellular spheroids. When individual spheroids with diameters of approximately 200 μm were transferred to test wells, their diameters increased by about 25 μm/day; colony-forming efficiencies were routinely 40–50%. The durations of …

Perturbed cell kinetics of 9L rat brain tumor cells following dianhydrogalactitol.

Kazuhiro Nomura, Takao Hoshino, Deen Df, Kathy D. Knebel

Kinetic changes induced by dianhydrogalactitol (DAG) in cultured 9L rat brain tumor cells were studied using conventional autoradiography and flow cytometry. Cell cycle parameters for the untreated cell line were: G1, 8.5 hours; S, 8.2 hours; G2, 3.2 hours; M, 0.5 hour; …

The distribution of nuclear DNA from human brain-tumor cells

Takao Hoshino, Kazuhiro Nomura, Charles B. Wilson, Kathy D. Knebel et autres

Flow cytometry (FCM) is a technique that measures the quantity of DNA contained in individual nuclei and records a frequency distribution of the DNA content per nucleus in the sampled cell population. Nuclei from a variety of human brain-tumor types were isolated …

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BCNU-induced perturbations in the cell cycle of 9L rat brain tumor cells.

Kazuhiro Nomura, Takao Hoshino, Kathy D. Knebel, Deen Df et autres

Effect of dibutyryl cAMP on cell cycle progression of rat brain tumor cells in vitro

Kazuhiro Nomura, Takao Hoshino, Kathy D. Knebel, Marvin Barker

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