P Wenzel

Deciphering human heart failure with preserved ejection fraction (HFpEF) at single cell resolution

Lukas Zanders, S F Glaser, Mariano Ruz Jurado, Moritz Brandt et autres

Abstract Background Heart Failure with preserved ejection fraction (HFpEF) is a complex condition driven by diverse aetiologies and pathogenic mechanisms. It is one of the leading causes of death in industrialised nations. Despite its growing prevalence, therapies that improve survival remain largely …

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Conditional over-expression of heme-oxygenase 1 in myelomonocytic cells attenuates vascular inflammation and prevents the development of heart failure in mice with excess neurohormonal activation

M Aluia, Q Luo, Marin Kuntić, S Finger et autres

Abstract Background Arterial hypertension is a systemic cardiovascular disorder associated with detrimental effects orchestrated by Angiotensin II (AngII) in the renin-angiotensin-aldosterone system (RAAS). AngII causes vascular dysfunction, inflammation, and tissue damage. Increased expression of heme oxygenase-1 (HO-1) may confer antioxidant and anti-inflammatory …

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Macrophage-expressed coagulation factor 7 promotes adverse cardiac remodeling

Venkata Garlapati, Qi Luo, Jens Posma, M Aluia et autres

Abstract Background Excess fibrotic remodeling leads to cardiac dysfunction in ischemic heart disease and is driven by MAP kinase-dependent transforming growth factor-ß1 (TGF-ß1) activation by coagulation signaling of myeloid cells. How coagulation-inflammatory circuits can be specifically targeted to achieve beneficial macrophage reprogramming …

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Coronary microvascular dysfunction in heart failure: observations from the MICRO registry

Ornela Velollari, Maximilian Olschweski, Karl‐Patrik Kresoja, Jutta Herzog et autres

Abstract Background Heart failure (HF) is one of the leading causes of hospitalization in the elderly. Coronary microvascular dysfunction (CMD), among other risk factors, is linked to the pathogenesis and clinical manifestations of HF. Purpose This abstract aims to summarize key findings …

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Effectiveness and tolerability of eptinezumab in treating patients with migraine resistant to conventional preventive medications and CGRP (receptor) antibodies: a multicentre retrospective real-world analysis from Germany

Armin Scheffler, P Wenzel, Merle Bendig, Astrid Gendolla et autres

BACKGROUND: Eptinezumab is a monoclonal antibody that targets calcitonin gene-related peptide (CGRP mAb) and is used for migraine prophylaxis. Efficacy data are mainly from clinical trials, real-world data are hardly available yet. Reimbursement policy in Germany leads to eptinezumab mainly being used …

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OC 49.4 Targeting Myeloid Cell Coagulation Signaling Blocks Map Kinase/TGF-β1 Driven Fibrotic Remodeling, Improves Cardiac Function and Improves Survival in Ischemic Heart Failure

Venkata Garlapati, Michael Molitor, Thomas Michna, Sonja Finger et autres

Telomere shortening in hypertensive heart disease depends on NOX2-mediated loss of PRDX1 and oxidative DNA damage

Maximilian Peter Brandt, Sana’a Khraisat, Hendrik Doerschmann, Sanela Kalinovic et autres

Abstract Background Heart failure (HF) coincides with cardiomyocyte telomere shortening. Arterial hypertension is the most prominent risk factor for HF. Both HF and arterial hypertension are associated with dysregulation of the neurohormonal axis and increased ROS. However, how neurohormonal activation is linked …

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Conditional over-expression of heme-oxygenase 1 in myelomonocytic cells reduces hypertension and vascular inflammation

M Aluia, Marin Kuntić, K. Jurk, Andreas Daiber et autres

Abstract Background Arterial hypertension is one of the most important modifiable risk factors for all-cause morbidity and mortality worldwide. Angiotensin II (Ang II) plays a pathogenic role in the development of hypertension, vascular dysfunction, inflammation and tissue damage. In the context of …

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Telomere shortening in heart failure due to excess neurohormonal activation is associated with loss of nuclear TRF-2 and increased telomeric DNA damage and predicts cardiac recovery

Maximilian Peter Brandt, H Doerschmann, Sanela Kalinovic, Andreas Daiber et autres

Abstract The mechanisms and clinical significance of telomere shortening in heart failure remain elusive. Mammalian cardiomyocyte (CM) regeneration is limited and CM cell division cannot account for telomere shortening. Whether telomere shortening in turn affects cardiac recovery remains unexplored. We induced heart …

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Poster session 1Cell growth, differentiation and stem cells - Heart72Understanding the metabolism of cardiac progenitor cells: a first step towards controlling their proliferation and differentiation?73Expression of pw1/peg3 identifies a new cardiac adult stem cell population involved in post-myocardial infarction remodeling74Long-term stimulation of iPS-derived cardiomyocytes using optogenetic techniques to promote phenotypic changes in E-C coupling75Benefits of electrical stimulation on differentiation and maturation of cardiomyocytes from human induced pluripotent stem cells76Constitutive beta-adrenoceptor-mediated cAMP production controls spontaneous automaticity of human induced pluripotent stem cell-derived cardiomyocytes77Formation and stability of T-tubules in cardiomyocytes78Identification of miRNAs promoting human cardiomyocyte proliferation by regulating Hippo pathway79A direct comparison of foetal to adult epicardial cell activation reveals distinct differences relevant for

E. André, Elisa Yaniz‐Galende, Charles Hamilton, Gregory J. Dusting et autres

Emerging evidence supports a mandatory metabolic shift from glycolysis to oxidative phosphorylation during stem cells differentiation. In this study, we investigate cardiac progenitor cells (CPC) metabolic adaptations to a hypoxic environment and the bioenergetic transition underlying cardiomyocyte differentiation process. We intend to …

Mitogenic Response of Peripheral Blood Lymphocytes from Patients with Graves' Disease Incubated with Solubilized Thyroid Cell Membranes Containing TSH Receptor and with Thyroglobulin

B. E. Wenzel, P Wenzel, Klaus Wenzel, Ringo Wenzel et autres

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