Zhaoqing Yin

Optimising data completeness and quality in multicentre randomised clinical trials using central data monitoring: a pragmatic approach

Markus Harboe Olsen, Mathias Lühr Hansen, Janus Engstrøm, Sanam Safi-Rasmussen et autres

BACKGROUND: Randomised clinical trial data monitoring is essential for ensuring quality and adherence to protocols, often achieved through on-site methods. However, challenges like the COVID-19 pandemic have highlighted limitations. Central data monitoring offers an alternative, leveraging digital capabilities and diverse expertise. METHODS: …

dk (code pays fourni par la source)

Metabolic dysfunction-associated steatotic liver disease and risk of four intrahepatic and extrahepatic diseases

Sihua Xu, Wenyan Hu, Jiapeng Huang, Deke Jiang et autres

INTRODUCTION AND OBJECTIVES: Recently, Delphi consensus proposed an overarching term steatotic liver disease (SLD), with various subcategories such as MASLD, MetALD and ALD. Our aim was to investigate the association between MASLD/MetALD/ALD and four intrahepatic and extrahepatic diseases (liver diseases, renal diseases, …

cn, hk (code pays fourni par la source)

Web-based training and certification of clinical staff during the randomised clinical trial SafeBoosC-III

Marie Isabel Rasmussen, Mathias Lühr Hansen, Colin Peters, Gorm Greisen et autres

BACKGROUND: SafeBoosC-III is a pragmatic, multinational clinical trial evaluating cerebral oximetry-guided treatment for extremely preterm infants. In total, 1601 infants were randomised across 70 sites in Asia, Europe, and USA. To enhance data quality and patient care, a web-based training program was …

dk, gb (code pays fourni par la source)

Cyanidin-3-O-glucoside alleviates ethanol-induced liver injury by promoting mitophagy in a Gao-binge mouse model of alcohol-associated liver disease

Qiao He, Zhaoqing Yin, Yunling Chen, Yunxiao Wu et autres

cn (code pays fourni par la source)

Correlation of DNA load, genotyping, and clinical phenotype of Mycoplasma pneumoniae infection in children

Wei Wang, Lu Wang, Zhaoqing Yin, Shujuan Zeng et autres

Introduction: DNA load in the bronchoalveolar lavage fluid (BALF) of children with MP pneumonia (MPP) and its subtypes, relevant laboratory data, imaging, extrapulmonary complications in infected children, and its clinical significance in evaluating the disease. Methods: Children hospitalized with MPP at Tianjin …

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Increased GABA signaling in liver macrophage promotes HBV replication in HBV-carrier mice

Yunling Chen, Zhaoqing Yin, Xiaonan Zhang, Yiwei Zhao et autres

Gamma-aminobutyric acid (GABA) signals in various non-neuronal cells including hepatocytes and some immune cells. Studies, including ours, show that type A GABA receptors (GABAARs)-mediated signaling occurs in macrophages regulating tissue-specific functions. Our recent study reveals that activation of GABAARs in liver macrophages …

cn, ca (code pays fourni par la source)

Detailed statistical analysis plan for a secondary Bayesian analysis of the SafeBoosC-III trial: a multinational, randomised clinical trial assessing treatment guided by cerebral oximetry monitoring versus usual care in extremely preterm infants

Markus Harboe Olsen, Mathias Lühr Hansen, Theis Lange, Christian Gluud et autres

BACKGROUND: Extremely preterm infants have a high mortality and morbidity. Here, we present a statistical analysis plan for secondary Bayesian analyses of the pragmatic, sufficiently powered multinational, trial-SafeBoosC III-evaluating the benefits and harms of cerebral oximetry monitoring plus a treatment guideline versus …

dk, Afrique du Sud, ca, ch (code pays fourni par la source)

Effect of different courses and durations of invasive mechanical ventilation on respiratory outcomes in very low birth weight infants

Yang Yang, Xinyue Gu, Zhenlang Lin, Shulin Pan et autres

This multicenter retrospective study was conducted to explore the effects of different courses and durations of invasive mechanical ventilation (MV) on the respiratory outcomes of very low birth weight infants (VLBWI) in China. The population for this study consisted of infants with …

cn, ca, us (code pays fourni par la source)

Comprehensive systematic review and meta-analysis of the association between common genetic variants and autism spectrum disorder

Yulian Fang, Yaqiong Cui, Zhaoqing Yin, Mengzhu Hou et autres

cn (code pays fourni par la source)

Effectiveness of Nasal Continuous Positive Airway Pressure vs Nasal Intermittent Positive Pressure Ventilation vs Noninvasive High-Frequency Oscillatory Ventilation as Support After Extubation of Neonates Born Extremely Preterm or With More Severe Respiratory Failure

Xingwang Zhu, Fang Li, Yuan Shi, Zhichun Feng et autres

Importance: The NASONE (Nasal Oscillation Post-Extubation) trial showed that noninvasive high-frequency oscillatory ventilation (NHFOV) slightly reduces the duration of invasive mechanical ventilation (IMV) in preterm infants, whereas NHFOV and noninvasive intermittent positive pressure ventilation (NIPPV) result in fewer reintubations than nasal continuous …

cn, fr (code pays fourni par la source)

Cerebral Oximetry Monitoring in Extremely Preterm Infants

Mathias Lühr Hansen, Adelina Pellicer, Simon Hyttel-Sørensen, Ebru Ergenekon et autres

BACKGROUND: The use of cerebral oximetry monitoring in the care of extremely preterm infants is increasing. However, evidence that its use improves clinical outcomes is lacking. METHODS: In this randomized, phase 3 trial conducted at 70 sites in 17 countries, we assigned …

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A frameshift mutation of TMPRSS3 in a Chinese family with non-syndromic hearing loss

Jingwen Liang, Zhuoheng Yu, Zhangxing Wang, Jianxia Chen et autres

Background Deafness is the most common sensory defect in humans worldwide. Approximately 50% of cases are attributed to genetic factors, and about 70% are non-syndromic hearing loss (NSHL). Objectives To identify clinically relevant gene variants associated with NSHL in a Chinese family …

cn (code pays fourni par la source)