Cerebral Oximetry Monitoring in Extremely Preterm Infants
Rattachement africain : dk, es, pl, ie, ch, be, us, it, gr, cz, cn, no, gb, de, in, tr, kh, fr. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: The use of cerebral oximetry monitoring in the care of extremely preterm infants is increasing. However, evidence that its use improves clinical outcomes is lacking. METHODS: In this randomized, phase 3 trial conducted at 70 sites in 17 countries, we assigned extremely preterm infants (gestational age, <28 weeks), within 6 hours after birth, to receive treatment guided by cerebral oximetry monitoring for the first 72 hours after birth or to receive usual care. The primary outcome was a composite of death or severe brain injury on cerebral ultrasonography at 36 weeks' postmenstrual age. Serious adverse events that were assessed were death, severe brain injury, bronchopulmonary dysplasia, retinopathy of prematurity, necrotizing enterocolitis, and late-onset sepsis. RESULTS: A total of 1601 infants underwent randomization and 1579 (98.6%) were evaluated for the primary outcome. At 36 weeks' postmenstrual age, death or severe brain injury had occurred in 272 of 772 infants (35.2%) in the cerebral oximetry group, as compared with 274 of 807 infants (34.0%) in the usual-care group (relative risk with cerebral oximetry, 1.03; 95% confidence interval, 0.90 to 1.18; P = 0.64). The incidence of serious adverse events did not differ between the two groups. CONCLUSIONS: In extremely preterm infants, treatment guided by cerebral oximetry monitoring for the first 72 hours after birth was not associated with a lower incidence of death or severe brain injury at 36 weeks' postmenstrual age than usual care. (Funded by the Elsass Foundation and others; SafeBoosC-III ClinicalTrials.gov number, NCT03770741.).
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Cerebral Oximetry Monitoring in Extremely Preterm Infants
- Date Crossref
- 20/04/2023
- Éditeur
- Massachusetts Medical Society
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Copenhagen University Hospital Center for Clinical Intervention Research pays non établi dans la noticeÉtablissement de santé
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Hospital Universitario La Paz pays non établi dans la noticeÉtablissement de santé
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Poznan University of Medical Sciences Neonatal Biophysical Monitoring and Cardiopulmonary Therapies Research Unit pays non établi dans la noticeUniversité ou école supérieure
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Temple Street Children's University Hospital pays non établi dans la noticeÉtablissement de santé
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University Hospital Zurich pays non établi dans la noticeÉtablissement de santé
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University Children's Hospital Zurich pays non établi dans la noticeÉtablissement de santé
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KU Leuven pays non établi dans la noticeUniversité ou école supérieure
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Hackensack University Medical Center Mountainside pays non établi dans la noticeÉtablissement de santé
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University of Milan Department of Clinical Sciences and Community Health pays non établi dans la noticeUniversité ou école supérieure
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Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico pays non établi dans la noticeÉtablissement de santé
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University of Patras pays non établi dans la noticeUniversité ou école supérieure
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University College Cork Infant Centre and Department of Paediatrics and Child Health pays non établi dans la noticeUniversité ou école supérieure
Center for Clinical Intervention Research — Copenhagen University Hospital, Hospital Universitario La Paz et Neonatal Biophysical Monitoring and Cardiopulmonary Therapies Research Unit — Poznan University of Medical Sciences, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.