Kenjiro Ito

WS05.02CFTR mRNA delivery with a revolutionary non-LNP nanoemulsion formulation to differentiated primary human airway epithelium and airway organoid

Kenjiro Ito, Shyreen Hassibi, Yoshio Yamamoto, Jag Shur et autres

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Impact of family physician–led hospitalist intervention methods in the multidisciplinary management of hip fracture: A retrospective cohort study

Naoto Ishimaru, Takahiro Waki, Toshio Shimokawa, Shimpei Mizuki et autres

HIP FRACTURES are associated with high mortality and morbidity, 1,2 the rates of which can be lowered by comprehensive hospital care.1,2 Geriatricians can play a major role in the comprehensive care of patients with hip fractures, although specialised geriatricians are limited in …

jp (code pays fourni par la source)

Perioperative surveillance of myocardial injury after non-cardiac surgery in patients with hip fracture: A retrospective cohort study

Naoto Ishimaru, Takahiro Waki, Toshio Shimokawa, Shimpei Mizuki et autres

Myocardial injury after non-cardiac surgery is due to ischaemia either during non-cardiac surgery or within 30 days after it. Our surveillance protocol includes hip fracture template and high-sensitivity troponin stratification, as recommended in European countries. Our retrospective study cohort included surgical patients …

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Impact of Flagging/Risk Stratification System on Complications in Hospitalist Hip Fracture Co-management: Retrospective Cohort Study

Naoto Ishimaru, Takahiro Waki, Toshio Shimokawa, Shimpei Mizuki et autres

jp (code pays fourni par la source)

Relationship between proximal femoral morphology and bone mineral density around the stem and the effects of osteoporosis treatment in patients with femoral neck fracture: a multicentre prospective cohort study

Keisuke Oe, Shinya Hayashi, Tomoaki Fukui, Kenichi Sawauchi et autres

Abstract Background This study aimed to classify older patients with femoral neck fractures who underwent hemiarthroplasty using a full hydroxyapatite-collared compaction short stem to evaluate the change in bone mineral density (BMD) around the stem. Methods This multicentre, prospective study included 96 …

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Multicenter study on atypical femoral fractures in patients with bone metastases taking bone- modifying agents

Tomoaki Fukui, Keisuke Oe, Teruya Kawamoto, Masayuki Morishita et autres

Bone-modifying agents (BMAs), with bone-resorptive inhibitory effects, such as zoledronic acid and denosumab, are widely used at higher doses for bone-related events caused by bone metastasis of malignant tumors. These drugs have been suggested to be associated with atypical femoral fractures (AFFs), …

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Supplementary Table S1 from TAS-116, a Highly Selective Inhibitor of Heat Shock Protein 90α and β, Demonstrates Potent Antitumor Activity and Minimal Ocular Toxicity in Preclinical Models

Shuichi Ohkubo, Yasuo Kodama, Hiromi Muraoka, Hiroko Hitotsumachi et autres

Supplementary Table S1: Inhibitory activity of TAS-116 and staurosporine against a panel of 48 protein kinases.

Supplementary Figure S1 from TAS-116, a Highly Selective Inhibitor of Heat Shock Protein 90α and β, Demonstrates Potent Antitumor Activity and Minimal Ocular Toxicity in Preclinical Models

Shuichi Ohkubo, Yasuo Kodama, Hiromi Muraoka, Hiroko Hitotsumachi et autres

Supplementary Figure S1: Biodistribution of ganetespib, 17-DMAG, or SNX-5422 in athymic nude rats with established NCI-H1975 xenografts.

Supplementary Table S3 from TAS-116, a Highly Selective Inhibitor of Heat Shock Protein 90α and β, Demonstrates Potent Antitumor Activity and Minimal Ocular Toxicity in Preclinical Models

Shuichi Ohkubo, Yasuo Kodama, Hiromi Muraoka, Hiroko Hitotsumachi et autres

Supplementary Table S3: Retinal and tumoral distributions of HSP90 inhibitors in an NCI-H1975 rat xenograft model.

Supplementary Table S2 from TAS-116, a Highly Selective Inhibitor of Heat Shock Protein 90α and β, Demonstrates Potent Antitumor Activity and Minimal Ocular Toxicity in Preclinical Models

Shuichi Ohkubo, Yasuo Kodama, Hiromi Muraoka, Hiroko Hitotsumachi et autres

Supplementary Table S2: Inhibitory effects of TAS-116 on the metabolic activities catalyzed by various human cytochrome P450 (CYP) enzymes.

Supplementary Figure S1 from TAS-116, a Highly Selective Inhibitor of Heat Shock Protein 90α and β, Demonstrates Potent Antitumor Activity and Minimal Ocular Toxicity in Preclinical Models

Shuichi Ohkubo, Yasuo Kodama, Hiromi Muraoka, Hiroko Hitotsumachi et autres

Supplementary Figure S1: Biodistribution of ganetespib, 17-DMAG, or SNX-5422 in athymic nude rats with established NCI-H1975 xenografts.

Supplementary Table S3 from TAS-116, a Highly Selective Inhibitor of Heat Shock Protein 90α and β, Demonstrates Potent Antitumor Activity and Minimal Ocular Toxicity in Preclinical Models

Shuichi Ohkubo, Yasuo Kodama, Hiromi Muraoka, Hiroko Hitotsumachi et autres

Supplementary Table S3: Retinal and tumoral distributions of HSP90 inhibitors in an NCI-H1975 rat xenograft model.