Xia-Hong You

Discovery of LD-110 as an Effective LSD1 PROTAC Degrader for the Treatment of Esophagus Squamous Cancer

Danyi Zhai, Lihua Liu, Changxin Zhong, Qian Chen et autres

LSD1, a pivotal epigenetic regulator mediating histone demethylation, is an attractive therapeutic target due to its oncogenic roles in cancers. Although numerous small-molecule inhibitors of LSD1 were advanced to clinical trials, only one PROTAC-based degrader was reported most recently. Here, we report …

Éthiopie, us, cn (code pays fourni par la source)

SHOC2 plays an oncogenic or tumor-suppressive role by differentially targeting the MAPK and mTORC1 signals in liver cancer

Xia-Hong You, Longyu Dou, Mingjia Tan, Xiufang Xiong et autres

Abstract SHOC2 is a scaffold protein that activates the RAS-MAPK signal. Our recent study showed that SHOC2 is also a negative regulator of the mTORC1 signal in lung cancer cells. Whether and how SHOC2 differentially regulates the RAS-MAPK vs. the mTORC1 signals …

cn, us (code pays fourni par la source)

The UBE2C/CDH1/DEPTOR axis is an oncogene and tumor suppressor cascade in lung cancer cells

Shizhen Zhang, Xia-Hong You, Yawen Zheng, Yanwen Shen et autres

Ubiquitin-conjugating enzyme E2C (UBE2C) mediates ubiquitylation chain formation via the K11 linkage. While previous in vitro studies showed that UBE2C plays a growth-promoting role in cancer cell lines, the underlying mechanism remains elusive. Still unknown is whether and how UBE2C plays a …

in, Éthiopie, cn (code pays fourni par la source)

PD-L1 induction via the MEK-JNK-AP1 axis by a neddylation inhibitor promotes cancer-associated immunosuppression

Shizhen Zhang, Xia-Hong You, Tiantian Xu, Qian Chen et autres

MLN4924 is a first-in-class small molecule inhibitor of NEDD8-activating enzyme (NAE), which is currently in several clinical trials for anti-cancer applications. However, MLN4924 also showed some off-target effects with potential to promote the growth of cancer cells which counteracts its anticancer activity. …

cn, us (code pays fourni par la source)

High-Grade Inflammation Attenuates Chemosensitivity and Confers to Poor Survival of Surgical Stage III CRC Patients

Hou‐Qun Ying, Xia-Hong You, Yu‐Cui Liao, Fan Sun et autres

Background: Heterogeneous clinical and molecular characteristics are reported in colorectal cancer (CRC) with different tumor laterality. However, the outcome of left- and right-sided patients with stage I–III CRC and the role of chronic inflammation in survival differences between them remain unclear. Method: …

cn (code pays fourni par la source)

A Novel Prognostic Score Based on ZG16 for Predicting CRC Survival

Wei Wang, Xiaozhong Wang, Hou‐Qun Ying, Xia-Hong You et autres

Background: Colorectal cancer (CRC) is one of the lethal malignant tumors worldwide. However, the underlying mechanism of CRC and its biomarkers remain unclear. The aim of this study was to identify the key genes associated with CRC and to further explore their …

cn (code pays fourni par la source)

Chemotherapy plus bevacizumab as an optimal first-line therapeutic treatment for patients with right-sided metastatic colon cancer: a meta-analysis of first-line clinical trials

Xia-Hong You, Yuhuan Jiang, Fan Sun, Yao Li et autres

Background Monoclonal antibodies of anti-epidermal growth factor receptor (EGFR) have been recommended as first-line therapy for patients with left-sided metastatic colorectal cancer (mCRC) with wild-type RAS . The effect of tumour laterality on antivascular endothelial growth factor antibody and how to optimise …

cn (code pays fourni par la source)

Optimization of urinary small extracellular vesicle isolation protocols: implications in early diagnosis, stratification, treatment and prognosis of diseases in the era of personalized medicine.

Qing-Gen Chen, Lian Chen, Qionghui Zhong, Lei Zhang et autres

Extracellular vesicles isolation from urine was severely interfered by polymeric Tamm-Harsefall protein due to its ability to entrap exosome. Studies had been reported to optimize the extraction of urine extracellular vesicles by using reducing agents, surfactants, salt precipitation or ultrafiltration, but rarely …

cn (code pays fourni par la source)

K562 cell-derived exosomes suppress the adhesive function of bone marrow mesenchymal stem cells via delivery of miR-711

Yuhuan Jiang, Jing Liu, Lin Jin, Shuqi Li et autres

cn (code pays fourni par la source)

Albumin to fibrinogen ratio and fibrinogen to pre-albumin ratio are economical, simple and promising prognostic factors for solid malignancy

Shuqi Li, Xia-Hong You, Fan Sun, Zijin Xia et autres

The exploration of cancer prognostic factor has received increasing attention in recent years. Traditional indicators such as tumor-node-metastasis system, histological subtype and carcinoembryonic antigen (CEA) have been recognized as prognostic indicators. However, invasiveness and high cost of these factors restrict the widespread …

cn (code pays fourni par la source)

Primary Tumor Sidedness Predicts Bevacizumab Benefit in Metastatic Colorectal Cancer Patients

Xia-Hong You, Can Wen, Zijin Xia, Fan Sun et autres

Emerging debate continues between primary tumor location and clinical outcome of bevacizumab treated metastatic colorectal cancer (mCRC). The aim of present study was to investigate the association between them in 115 mCRC patients, and a meta-analysis including 21 studies was carried out …

cn (code pays fourni par la source)

Elevated FPR confers to radiochemoresistance and predicts clinical efficacy and outcome of metastatic colorectal cancer patients

Qing-Gen Chen, Lei Zhang, Fan Sun, Shuqi Li et autres

Association of chronic inflammation, primary tumor sidedness, adjuvant therapy and survival of metastatic colorectal cancer (mCRC) remains unclear. Circulating inflammatory cell, fibrinogen (Fib), albumin (Alb), pre-albumin (pAlb), Alb/Fib (AFR) and Fib/pAlb (FPR) were detected, and clinical outcome was obtained to determine the …

cn (code pays fourni par la source)