Katie Yates Harvey

The development of a novel pluripotent cell-based assay for human IVF media quality control

Naki A. Adjirackor, Tom Beckitt, Katie Yates Harvey, Simon Crawford Harvey

Quality control systems for assays and assay components are crucial to achieving optimum standards in healthcare. In human IVF, the mouse embryo assay is commonly used to assess the quality of media and instruments. Despite its popularity, there are some well-known issues …

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Vegetation structure and aboveground biomass of Páramo peatlands along a high-elevation gradient in the northern Ecuadorian Andes

Esteban Suárez, John A. Hribljan, Segundo Chimbolema, Katie Yates Harvey et autres

The high-elevation peatlands of the páramos of the northern Andes constitute a diverse environment that harbors large numbers of species and several types of plant communities along altitudinal, latitudinal, and environmental gradients. However, little is known about the structure and functioning of …

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TRPM7 deficiency exacerbates cardiovascular and renal damage induced by aldosterone-salt

Francisco J. O. Rios, Zhiguo Zou, Adam Harvey, Katie Yates Harvey et autres

Abstract Hyperaldosteronism causes cardiovascular disease as well as hypomagnesemia. Mechanisms are ill-defined but dysregulation of TRPM7, a Mg2+-permeable channel/α-kinase, may be important. We examined the role of TRPM7 in aldosterone-dependent cardiovascular and renal injury by studying aldosterone-salt treated TRPM7-deficient (TRPM7+/Δkinase) mice. Plasma/tissue …

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Laboratory Diagnosis and Monitoring of Lysosomal Storage Diseases

BRYAN G. WINCHESTER, Clare E. Beesley, Derek G. Burke, Katie Yates Harvey et autres

The route to a definitive diagnosis is based upon the clinical presentation and genetic and bio chemical laboratory tests on blood and urine. The definitive diagnosis of lysosomal storage diseases (LSDs) is based upon demonstrating a genetic and functional defect in a …

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Osteoprotegerin regulates vascular function through syndecan-1 and NADPH oxidase-derived reactive oxygen species

Rhéure Alves-Lopes, Karla Bianca Neves, Anastasiya Strembitska, Adam Harvey et autres

Osteogenic factors, such as osteoprotegerin (OPG), are protective against vascular calcification. However, OPG is also positively associated with cardiovascular damage, particularly in pulmonary hypertension, possibly through processes beyond effects on calcification. In the present study, we focused on calcification-independent vascular effects of …

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TRPM7 IS PROTECTIVE AGAINST CARDIOVASCULAR DAMAGE INDUCED BY ALDOSTERONE AND SALT

Francisco J. O. Rios, Zhi -Guo Zou, Adam Harvey, Katie Yates Harvey et autres

Objective: TRPM7 is a channel-kinase that regulates cellular signaling and Mg2+ homeostasis. We demonstrated that TRPM7 is protective against cardiac inflammation and dysfunction. Since hyperaldosteronism causes hypertension and Mg2+ wasting, we questioned whether TRPM7 plays a role in aldosterone-induced hypertension and fibrosis. …

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A genetic and clinical study of individuals with nonsyndromic retinopathy consequent upon sequence variants in HGSNAT , the gene associated with Sanfilippo C mucopolysaccharidosis

Elena Schiff, Malena Daich Varela, Anthony G. Robson, Karen Pierpoint et autres

Pathogenic variants in the gene HGSNAT (heparan-α-glucosaminide N-acetyltransferase) have been reported to underlie two distinct recessive conditions, depending on the specific genotype, mucopolysaccharidosis type IIIC (MPSIIIC)-a severe childhood-onset lysosomal storage disorder, and adult-onset nonsyndromic retinitis pigmentosa (RP). Here we describe the largest …

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Estrogen metabolites in a small cohort of patients with idiopathic pulmonary arterial hypertension

Nina Denver, Natalie Z M Homer, Ruth Andrew, Katie Yates Harvey et autres

Increased risk and severity of idiopathic pulmonary arterial hypertension (iPAH) is associated with elevated estradiol in men and postmenopausal women. Pulmonary arteries synthesise estradiol via aromatase and metabolise it via CYP1B1 to mitogenic metabolites; SNPs in aromatase and CYP1B1 have been associated …

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Chanzyme TRPM7 protects against cardiovascular inflammation and fibrosis

Francisco J. O. Rios, Zhiguo Zou, Adam Harvey, Katie Yates Harvey et autres

AIMS: Transient Receptor Potential Melastatin 7 (TRPM7) cation channel is a chanzyme (channel + kinase) that influences cellular Mg2+ homeostasis and vascular signalling. However, the pathophysiological significance of TRPM7 in the cardiovascular system is unclear. The aim of this study was to …

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Obesity alters oestrogen metabolism and contributes to pulmonary arterial hypertension

Kirsty M. Mair, Katie Yates Harvey, Alasdair D. Henry, Dianne Z. Hillyard et autres

Obesity is a common comorbidity for pulmonary arterial hypertension (PAH). Additionally, oestrogen and its metabolites are risk factors for the development of PAH. Visceral adipose tissue (VAT) is a major site of oestrogen production; however, the influence of obesity-induced changes in oestrogen …

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The evolving role of enzymology and metabolomics in the diagnosis of lysosomal disorders in the post-genomic era

Katie Yates Harvey, Derek G. Burke, Simon Heales

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Urinary glucose tetrasaccharide, a useful prognostic biomarker for Pompe disease?

Simon Heales, Katie Yates Harvey, Maureen Cleary, Helen Prunty et autres

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