Yanfang Ding

ROS-activated prodrug nano-assemblies based on cinnamaldehyde-modified paclitaxel for treating breast cancer

Yali Chen, Lei Qian, Chunyun Xu, Hongjie Huo et autres

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Cascade-responsive nanoplatform for synergistic cancer therapy via ROS amplification and hypoxia targeting

Chunyun Xu, Yanfang Ding, Jingjing Qi, Peng Chu et autres

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Intelligent triggering of nanomicelles based on a ROS-activated anticancer prodrug and photodynamic therapy (PDT)-synergistic therapy for lung cancers

Lixue Chen, Ruping Xu, Yanfang Ding, Changyuan Wang et autres

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Development of Biomimetic Hepatic Lobule-Like Constructs on Silk-Collagen Composite Scaffolds for Liver Tissue Engineering

Lina Guo, Ziqing Zhu, Chuanzhou Gao, Kaiwen Chen et autres

Constructing an engineered hepatic lobule-mimetic model is challenging owing to complicated lobular architecture and crucial hepatic functionality. Our previous study has demonstrated the feasibility of using silk fibroin (SF) scaffolds as functional templates for engineering hepatic lobule-like constructs. But the unsatisfactory chemical …

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Honokiol Prodrug Nanoparticles Based on In Situ Albumin Binding for Long Circulation and High Tumor Uptake

Lixue Chen, Shengnan Li, Yanfang Ding, Changyuan Wang et autres

Honokiol (HK) has antiproliferation effects against numerous cancer cells, but its low solubility and bioavailability impede its application. In this study, a prodrug of HK (HP) featuring a maleimide group was synthesized and then mixed with tocopherol polyethylene glycol succinate to prepare …

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miR-206 as a prognostic and sensitivity biomarker for platinum chemotherapy in epithelial ovarian cancer

Xiaotang Yu, Xinchen Zhang, Guang Wang, Bo Wang et autres

BACKGROUND: Drug resistance is a major obstacle to successful chemotherapy for epithelial ovarian cancer (EOC). We found a subset of miRNAs associated with the response to first-line platinum-based chemotherapy in EOC by microarray, and miR-206 was one of the most significant miRNAs. …

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Fenretinide-polyethylene glycol (PEG) conjugate with improved solubility enhanced cytotoxicity to cancer cell and potent in vivo efficacy

Yutong Wang, Yanfang Ding, Changyuan Wang, Meng Gao et autres

Fenretinide (4-HPR), a synthetic retinoid, has shown its antitumor activity in many tumor types with low cytotoxicity to normal cells and high clinical safety. However, the low water solubility limits its further biological applications. To increase solubility, 4-HPR was conjugated with methoxy …

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Mixed micelles of TPGS and Soluplus® for co-delivery of paclitaxel and fenretinide: in vitro and in vivo anticancer study

Yutong Wang, Yanfang Ding, Youwei Xu, Changyuan Wang et autres

Fenretinide (4-HPR), as a semi-synthetic retinoid, has apoptosis-promoting effects as a single agent and chemotherapy synergist in vitro. When a human ovarian cancer cells line (A2780s) was treated with both PTX and 4-HPR, there was a synergistic anti-cancer effect demonstrated with a …

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Soluplus ® /TPGS mixed micelles for co-delivery of docetaxel and piperine for combination cancer therapy

Yanfang Ding, Yingying Ding, Yutong Wang, Changyuan Wang et autres

In this study, mixed micelles of Soluplus® and TPGS were developed for co-administering docetaxel (DTX) and piperine (PIP) for exerting the synergistic effect, which increased the cytotoxicity and improved the anti-cancer activity in HepG2 cell lines compared to free DTX. These in …

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Dihydroartemisinin and doxorubicin co-loaded Soluplus®-TPGS mixed micelles: formulation characterization, cellular uptake, and pharmacodynamic studies

Yutong Wang, Yanfang Ding, Jing Zhao, Changyuan Wang et autres

Clinically, co-delivery of chemotherapeutics has been limited by poor water-solubility and severe systemic toxicity. This study was aimed at integrating the merits of combination chemotherapy and mixed micellar technology and demonstrating the anticancer potential of doxorubicin (DOX) and dihydroartemisinin (DHA) co-loaded Soluplus®-TPGS …

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Three-dimensional tissue culture model of human breast cancer for the evaluation of multidrug resistance

Yanfang Ding, Wei Liu, Weiting Yu, Shenzhou Lu et autres

Multidrug resistance (MDR) is one of the major obstacles to improving outcomes of chemotherapy in tumour patients. However, progress has been slow to overcome this phenomenon due to the limitations of current cell/tissue models in recapitulating MDR behaviour of tumour cells in …

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Development and evaluation of a novel drug delivery: Soluplus®/TPGS mixed micelles loaded with piperine in vitro and in vivo

Yingying Ding, Changyuan Wang, Yutong Wang, Youwei Xu et autres

Background: Although piperine can inhibit cells of tumors, the poor water solubility restricted its clinical application. This paper aimed to develop mixed micelles based on Soluplus® and D-α-tocopherol polyethylene glycol succinate (TPGS) to improve the aqueous solubility and anti-cancer effect.Methods: Piperine-loaded mixed …

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