Marina Fink

Cigarette smoke exposure reduces hemorrhagic shock induced circulatory dysfunction in mice with attenuated glucocorticoid receptor function

Martin Wepler, Jonathan M. Preuss, Cornelia Tilp, Martina Keck et autres

Introduction We previously showed that attenuated glucocorticoid receptor (GR) function in mice (GRdim/dim) aggravates systemic hypotension and impairs organ function during endotoxic shock. Hemorrhagic shock (HS) causes impaired organ perfusion, which leads to tissue hypoxia and inflammation with risk of organ failure. …

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Impaired Glucocorticoid Receptor Dimerization Aggravates LPS-Induced Circulatory and Pulmonary Dysfunction

Martin Wepler, Jonathan M. Preuss, Tamara Merz, Clair Hartmann et autres

Background: Sepsis as an acute systemic inflammation syndrome is the most common cause for acute lung injury (ALI). ALI induces acute respiratory failure leading to hypoxemia, which is often associated with multiple organ failure (MOF). During systemic inflammation, the hypothalamus-pituitary-adrenal axis (HPA) …

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The Mitochondria-Targeted H2S-Donor AP39 in a Murine Model of Combined Hemorrhagic Shock and Blunt Chest Trauma

Martin Wepler, Tamara Merz, Ulrich Wachter, J. Vogt et autres

Hemorrhagic shock (HS) accounts for 30% to 40% of trauma-induced mortality, which is due to multi-organ-failure subsequent to systemic hyper-inflammation, triggered by hypoxemia and tissue ischemia. The slow-releasing, mitochondria-targeted H2S donor AP39 exerted beneficial effects in several models of ischemia-reperfusion injury and …

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Effects of Psychosocial Stress on Subsequent Hemorrhagic Shock and Resuscitation in Male Mice

Dominik Langgartner, Ulrich Wachter, Clair Hartmann, Michael Gröger et autres

BACKGROUND: Hypoxemia and tissue ischemia during hemorrhage as well as formation of oxygen and nitrogen radicals during resuscitation promote hyperinflammation and, consequently, trigger severe multi-organ failure (MOF). Individuals diagnosed with stress-related disorders or reporting a life history of psychosocial stress are characterized …

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A TLR4/MD2 fusion protein inhibits LPS-induced pro-inflammatory signaling in hepatic stellate cells

Bernd Schnabl, Katharina Brandl, Marina Fink, Philipp Groß et autres

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Characterization of the human zinc finger protein 267 promoter: Essential role of nuclear factor Y

Kanghong Hu, Marina Fink, Matthias Froh, Erwin Gäbele et autres

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ETHYL PYRUVATE INHIBITS NF-κ B ACTIVATION THROUGH SCAVENGING OXIDANTS AND, PARODOXICALLY, DEPLETING GSH.

Mingchen Song, John A. Kellum, Hoda Kaldas, Marina Fink

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Therapeutic options directed against platelet activating factor, eicosanoids and bradykinin in sepsis

Marina Fink

Various autacoids, including the eicosanoids, platelet activating factor (PAF) and bradykinin, have been implicated in the pathogenesis of sepsis and septic shock. The precise role of these compounds as mediators of the diffuse inflammatory state characteristic of sepsis remains to be determined, …

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EUK-8, a synthetic superoxide dismutase and catalase mimetic, ameliorates acute lung injury in endotoxemic swine.

Pamela K. Gonzalez, Jingjing Zhuang, Susan R. Doctrow, Bernard Malfroy et autres

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EUK-8, A SYNTHETIC SUPEROXIDE DISMUTASE (SOD), and CATALASE (CAT) MIMETIC, AMELIORATES ENDOTOXIN-INDUCED ACUTE LUNG INJURY

Pamela K. Gonzalez, Jing Zhuang, Susan R. Doctrow, Bernard Malfroy et autres

Acute lung injury in endotoxemic pigs: role of leukotriene B4

Thomas J. VanderMeer, Michael J. Menconi, Brian O’Sullivan, V. A. Larkin et autres

The role of leukotriene B4 (LTB4) in the pathogenesis of acute lung injury was examined in endotoxemic pigs. In a preliminary study, the activity and specificity of an LTB4-receptor antagonist, LY-306669, were evaluated. In vitro, LY-306669 completely blocked the functional upregulation of …

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LY255283, a novel leukotriene B4 receptor antagonist, limits activation of neutrophils and prevents acute lung injury induced by endotoxin in pigs.

P. Staffan Wollert, Michael J. Menconi, Brian O’Sullivan, H Wang et autres

BACKGROUND: Polymorphonuclear neutrophils (PMNs) have been implicated in the pathogenesis of the adult respiratory distress syndrome (ARDS). Because leukotriene B4 (LTB4) is a potent activator of PMNs, we sought to determine whether LY255283, an LTB4 receptor antagonist, could block PMN activation and …

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