1998
article
OpenAlex
A. Camerota, Abla A. Creasey, Venkat Patla, V. A. Larkin et autres
To determine whether treatment with recombinant human tissue factor pathway inhibitor (TFPI), an inhibitor of the extrinsic coagulation pathway, can improve survival in a clinically relevant model of gram-negative sepsis, rabbits were given an intraperitoneal inoculation of a suspension containing hemoglobin (40 …
us
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Accès ouvert
1997
article
OpenAlex
Naoki Unno, H Wang, MJ Menconi, Stefaan H.A.J. Tytgat et autres
us
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1997
article
OpenAlex
A. Camerota, Lennart Lögdberg, Phil Lake, V. A. Larkin et autres
Polymyxin B (PMB) is an amphipathic nephrotoxic antibiotic, which has been shown to neutralize the effects of endotoxin both in vitro and in vivo. PMB-D70 (PMX-622), a covalent conjugate of PMB with dextran 70 (D70), is less nephrotoxic than the parent compound. …
us
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1996
article
OpenAlex
Venkat Patla, A. Camerota, V. A. Larkin, Abla A. Creasey et autres
Patla, V. R.; Camerota, A. J.; Larkin, V. A.; Creasey, A.; Fink, M. P. Author Information
1996
article
OpenAlex
Jonathan S. Aranow, Jing Zhuang, Hailong Wang, V. A. Larkin et autres
We evaluated the effects on survival of three different strategies for blocking the actions of nitric oxide (NO) during Gram-negative sepsis in rats. Male Sprague-Dawley rats underwent placement of a jugular vein catheter and i.p. implantation of a gelatin capsule containing a …
us
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1995
article
OpenAlex
Thomas J. VanderMeer, Michael J. Menconi, Brian O’Sullivan, V. A. Larkin et autres
The role of leukotriene B4 (LTB4) in the pathogenesis of acute lung injury was examined in endotoxemic pigs. In a preliminary study, the activity and specificity of an LTB4-receptor antagonist, LY-306669, were evaluated. In vitro, LY-306669 completely blocked the functional upregulation of …
us
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1994
article
OpenAlex
P. Staffan Wollert, Michael J. Menconi, Hailong Wang, Brian O’Sullivan et autres
We sought to determine whether a standardized "priming" event, namely a small dose of LPS, would alter physiological responses to a subsequent larger "challenge" dose of endotoxin. Accordingly, four groups of pigs (N = 5-6) were studied. One group received neither priming …
us
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1994
article
OpenAlex
Thomas J. VanderMeer, Michael J. Menconi, Brian O’Sullivan, V. A. Larkin et autres
Bactericidal/permeability-increasing protein (BPI), a cationic protein isolated from human neutrophils, binds lipopolysaccharide (LPS), kills gram-negative bacteria, and neutralizes many of the effects of LPS in vitro and in vivo. We hypothesized that a recombinant 23-kDa NH2-terminal fragment of BPI (BPI23) would reduce …
us
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1994
conference-abstract
OpenAlex
Thomas J. VanderMeer, Michael J. Menconi, V. A. Larkin, Michael J. Sofia et autres
VanderMeer, T.; Menconi, M.; O'Sullivan, B.; Larkin, V.; Sofia, M.; Fink, H. Author Information
us
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1993
article
OpenAlex
P. Staffan Wollert, Michael J. Menconi, Brian O’Sullivan, H Wang et autres
BACKGROUND: Polymorphonuclear neutrophils (PMNs) have been implicated in the pathogenesis of the adult respiratory distress syndrome (ARDS). Because leukotriene B4 (LTB4) is a potent activator of PMNs, we sought to determine whether LY255283, an LTB4 receptor antagonist, could block PMN activation and …
us
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