Lynette Chee

POSTER: MPN-481: Mutant Calreticulin-Specific Monoclonal Antibody, INCA033989, is Well Tolerated and Achieves Rapid and Sustained Hematologic and Molecular Responses in Patients With Essential Thrombocythemia

Haris Ali, Tania Jain, Aaron T. Gerds, Vikas Gupta et autres

us, ca, gb, au, jp, de, fr, it (code pays fourni par la source)

MPN-481: Mutant Calreticulin-Specific Monoclonal Antibody, INCA033989, is Well Tolerated and Achieves Rapid and Sustained Hematologic and Molecular Responses in Patients With Essential Thrombocythemia

Haris Ali, Tania Jain, Aaron T. Gerds, Vikas Gupta et autres

us, ca, gb, au, jp, de, fr, it (code pays fourni par la source)

Safety and efficacy of INCA033989, a novel first in class mutant calreticulin-specific monoclonal antibody, in patients with essential thrombocythemia

Vikas Gupta, John Mascarenhas, Haris Ali, David M. Ross et autres

Abstract Background: Essential thrombocythemia (ET) is a myeloproliferative neoplasm with increased risk of thrombosis, hemorrhage, and transformation to myelofibrosis (MF) or acute myeloid leukemia. About 25% of patients (pts) with ET harbor calreticulin exon 9 mutations (mutCALR). Current cytoreductive treatments (tx) in …

ca, us, au, fr, jp, es, de, it, gb (code pays fourni par la source)

The Changing Epidemiology of Breakthrough Invasive Fungal Disease in Allogeneic Hematopoietic Stem Cell Transplant Recipients in the Era of Modified‐Release Posaconazole Prophylaxis

Shio Yen Tio, Chin Fen Neoh, David Ritchie, Lynette Chee et autres

BACKGROUND: Allogeneic hemopoietic stem cell transplant (aHSCT) recipients are at high-risk for invasive fungal disease (IFD), even with mould-active antifungal prophylaxis (AFP). METHODS: This was a retrospective, observational, single-center cohort study involving 300 adult aHSCT recipients transplanted from January 2017-May 2020. Patient …

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MDS-1047: RENEW Trial in Progress: A Phase 3, Double-Blind, Placebo-Controlled Study to Evaluate Elritercept in Participants With Transfusion-Dependent Anemia and Lower-Risk Myelodysplastic Neoplasms

Rami S. Komrokji, María Diez‐Campelo, Lynette Chee, Amy E. DeZern et autres

us, es, au, fr, de, it, ca (code pays fourni par la source)

ANZTCT consensus position statement on ruxolitinib in steroid‐refractory acute and chronic graft‐versus‐host disease

Nada Hamad, Ian Bilmon, Lynette Chee, Andrea Henden et autres

This position paper provides an overview of the assessment and management of both acute and chronic graft-versus-host disease (GvHD). There is a focus on the use of ruxolitinib, a selective inhibitor of Janus kinase (JAK)1 and JAK2, for the treatment of corticosteroid-refractory …

au, nz (code pays fourni par la source)

Robust SARS-CoV-2 T cell responses with common TCRαβ motifs toward COVID-19 vaccines in patients with hematological malignancy impacting B cells

Thi H. O. Nguyen, Louise C. Rowntree, Lilith F. Allen, Brendon Y. Chua et autres

T cells, together with their T cell receptor (TCR) repertoires, were robust in hematology patients, irrespective of B cell numbers, and comparable to healthy participants. Vaccinated patients with breakthrough infections developed higher antibody responses, while T cell responses were comparable to healthy …

au, jp, us, ca, gb (code pays fourni par la source)

Effective CMV prophylaxis with high‐dose valaciclovir in allogeneic hematopoietic stem‐cell recipients at a high risk of CMV infection

Genevieve Douglas, Michelle K. Yong, Shio Yen Tio, Maggie Chau et autres

BACKGROUND: Cytomegalovirus (CMV) infection increases mortality and morbidity following allogeneic hematopoietic stem-cell transplantation (alloHSCT). Universal antiviral prophylaxis with letermovir is effective but unsubsidized in Australia. Valaciclovir demonstrates anti-CMV activity in high doses, but few current real-world studies explore its use as primary …

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Australia and New Zealand Transplant and Cellular Therapies (ANZTCT) position statement: COVID ‐19 management in patients with haemopoietic stem cell transplant and chimeric antigen receptor T cell

Jacinta Perram, Duncan Purtill, Ashish Bajel, Jason Butler et autres

Patients with post-haemopoietic stem cell transplant or chimeric antigen receptor T -cell (CAR-T) therapy face a significant risk of morbidity and mortality from coronavirus disease 2019 because of their immunosuppressed state. As case numbers in Australia and New Zealand continue to rise, …

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P776: A PHASE 2, OPEN-LABEL, ASCENDING DOSE STUDY OF KER-050 FOR THE TREATMENT OF ANEMIA IN PATIENTS WITH VERY LOW, LOW, OR INTERMEDIATE RISK MYELODYSPLASTIC SYNDROMES

Sih Min Tan, Alejandro Arbelaez, Lynette Chee, Chun Yew Fong et autres

Background: Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis; many patients develop high transfusion burden (HTB) requiring ≥4 units RBCs every 8 weeks and have high unmet medical need. KER-050, an investigational modified activin receptor type IIA inhibitor, is designed to target …

au, nz (code pays fourni par la source)

Image-guided Radiotherapy to Manage Respiratory Motion: Lung and Liver

Jennifer Dhont, Susan Harden, Lynette Chee, K. Aitken et autres

Organ motion as a result of respiratory and cardiac motion poses significant challenges for the accurate delivery of radiotherapy to both the thorax and the upper abdomen. Modern imaging techniques during radiotherapy simulation and delivery now permit better quantification of organ motion, …

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MonoMac syndrome with associated neurological deficits and longitudinally extensive cord lesion

Mastura Monif, Aamira Huq, Lynette Chee, Trevor J. Kilpatrick

We present a case of monocytopaenia and mycobacteria-related infection (MonoMac) syndrome in a 30-year-old man of Indian origin. The clinical diagnosis of GATA2 haploinsufficiency was suspected after an unusual neurological presentation on a background of myelodysplastic syndrome and childhood pulmonary tuberculosis. The …

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