Kenjiro Sato

Structure–Activity Relationship Study of Antimalarial Asparagine-Derived Proteasome Inhibitors

Hao Zhang, Daqiang Li, Hao-Chi Hsu, Akshay Vishwanatha et autres

Abstract Malaria remains a significant global health threat, affecting millions of lives each year. The causative agents, Plasmodium parasites, are highly resilient and have developed resistance to nearly all existing antimalarial drugs. The Plasmodium 20S proteasome core (Pf20S), a central component of …

us, Ouganda (code pays fourni par la source)

Trends and Outcomes of Mechanical Support Use in Surgical Repair of Ventricular Septal Defect after Myocardial Infarction

Masanobu Miura, Yuta Kagaya, Hiroki Saito, Kenjiro Sato et autres

Ventricular septal defect after myocardial infarction (MI-VSD) is a rare but fatal complication. This real-world database study reports the patient characteristics and outcomes after surgical repair of MI-VSD based on the Japanese Registry of All Cardiac and Vascular Diseases Diagnosis Procedure Combination …

jp, be (code pays fourni par la source)

Cardiac Malignant Lymphoma with Diffuse Extension to the Left Ventricle

Daichi Terunuma, Masanobu Miura, Ko Teshima, Yuta Kagaya et autres

Malignant cardiac lymphoma is rare and commonly involves nodules on the right side of the heart. We herein report a case of malignant cardiac lymphoma with diffuse extension into the left ventricle. The patient was a woman in her 60s who complained …

jp (code pays fourni par la source)

An Autopsy Case of Fulminant Myocarditis with Massive Left Ventricular Calcification

Satsuki Yagi-Nakajima, Masanobu Miura, Shun Sawada, Takahiro Funaki et autres

Myocardial calcification in myocarditis is rare and may be linked to poor outcomes. We herein report a case of fulminant myocarditis with massive myocardial calcification and its pathological outcomes at autopsy. A 49-year-old man experienced chest pain and was diagnosed with acute …

jp (code pays fourni par la source)

Infectious Pulmonary Artery Pseudoaneurysm Secondary to a Lung Abscess Treated With Pulmonary Artery Coil Embolization: A Case Report

Takumi Murakami, Yutaro Otomo, Tatsuya Ito, Kenjiro Sato et autres

Pulmonary artery pseudoaneurysms (PAPs) are uncommon, yet they frequently result in hemoptysis and are associated with a poor prognosis. We report a case of an 87-year-old male patient. Initially, he was admitted to a previous hospital, and diagnosed with a lung abscess …

jp (code pays fourni par la source)

Impact of pemafibrate on lipid profile and insulin resistance in hypertriglyceridemic patients with coronary artery disease and metabolic syndrome

Akihiro Nakamura, Yuta Kagaya, Hiroki Saito, Masanori Kanazawa et autres

jp (code pays fourni par la source)

Efficacy and Safety of Pemafibrate Versus Bezafibrate to Treat Patients with Hypertriglyceridemia: A Randomized Crossover Study

Akihiro Nakamura, Yuta Kagaya, Hiroki Saito, Masanori Kanazawa et autres

Results: The %Change in TG and Apo A-I levels was significantly greater with pemafibrate than with bezafibrate (-46.1% vs. -34.7%,p＜0.001; 9.2% vs. 5.7%, p=0.018, respectively).%Change in HDL-C levels was not significantly different between the two treatments.%Change in liver enzyme levels was markedly …

Discovery of a Novel Series of Potent, Selective, Orally Available, and Brain-Penetrable C1s Inhibitors for Modulation of the Complement Pathway

Zenichi Ikeda, Taku Kamei, Yusuke Sasaki, Matthew Reynolds et autres

High Resolution Image Download MS PowerPoint Slide A novel series of non-amidine-based C1s inhibitors have been explored. Starting from high-throughput screening hit 3, isoquinoline was replaced with 1-aminophthalazine to enhance C1s inhibitory activity while exhibiting good selectivity against other serine proteases. We …

jp, us (code pays fourni par la source)

Effects of switching from sacubitril/valsartan to valsartan alone on plasma levels of natriuretic peptides and myocardial remodeling in heart failure with reduced ejection fraction

Akihiro Nakamura, Yuta Kagaya, Hiroki Saito, Masanori Kanazawa et autres

Abstract Background We examined the effect of switching from angiotensin receptor-neprilysin inhibitor (ARNI) to angiotensin-receptor blocker (ARB) on plasma levels of natriuretic peptides and myocardial remodeling. Methods This is a prospective study that included 11 patients with heart failure (HF) treated with …

jp (code pays fourni par la source)

Structure–Activity Relationship Studies of Antimalarial Plasmodium Proteasome Inhibitors─Part II

Hao Zhang, John D. Ginn, Wenhu Zhan, Annie Leung et autres

With increasing reports of resistance to artemisinins and artemisinin-combination therapies, targeting the Plasmodium proteasome is a promising strategy for antimalarial development. We recently reported a highly selective Plasmodium falciparum proteasome inhibitor with anti-malarial activity in the humanized mouse model. To balance the …

us, Ouganda (code pays fourni par la source)

Effects of switching from sacubitril/valsartan to valsartan alone on plasma levels of natriuretic peptides and myocardial remodeling in heart failure with reduced ejection fraction

Akihiro Nakamura, Yuta Kagaya, Hiroki Saito, Masanori Kanazawa et autres

Abstract Background: We examined the effect of switching from angiotensin receptor-neprilysin inhibitor (ARNI) to angiotensin-receptor blocker (ARB) on plasma levels of natriuretic peptides and myocardial remodeling. Methods: This is a prospective study that included 11 patients with heart failure (HF) treated with …

jp (code pays fourni par la source)

Efficacy and Safety of Pemafibrate Versus Bezafibrate to Treat Patients with Hypertriglyceridemia: A Randomized Crossover Study

Akihiro Nakamura, Yuta Kagaya, Hiroki Saito, Masanori Kanazawa et autres

AIM: Pemafibrate is a highly selective agonist for peroxisome proliferator-activated receptor (PPAR)-α, a key regulator of lipid and glucose metabolism. We compared the efficacy and safety of pemafibrate with those of bezafibrate, a nonselective PPAR-α agonist. METHODS: In this randomized crossover study, …

jp (code pays fourni par la source)