Jialing He

HDCA Supplementation During Maternal High-Fat Diet Exposure Is Associated with Offspring Gut Microbiota at Weaning and Adult Metabolic Phenotypes in a Mouse Model

Halizere Simayi, Yating Yang, Li Gao, Bin Yu et autres

Background/Objective: Maternal diet is an important determinant of gut microbiota composition in dams and offspring. This study investigated whether HDCA supplementation during maternal high-fat diet (HFD) exposure was associated with gut microbiota composition in dams and offspring and with selected obesity-related phenotypes. …

cn (code pays fourni par la source)

Hyodeoxycholic Acid Suppresses High-Fat-Diet–Promoted MC38-Syngeneic Colorectal Tumor Growth via Bile Acid Remodeling and Microbiota Modulation

Jialing He, Meng Duan, Simayi Halizere, Ningxin Chen et autres

BACKGROUND: Studies have shown that obesity contributes to colorectal tumors (CRC). Hyodeoxycholic acid (HDCA) has been found to have a therapeutic effect on obesity-related diseases such as nonalcoholic fatty liver (NAFLD). However, there are still no studies revealing whether HDCA has effects …

cn (code pays fourni par la source)

Expression profiles and gene set enrichment analysis of the transcriptomes from the cancer tissue, white adipose tissue and paracancer tissue with colorectal cancer

Xiufeng Zhang, Rui Zhu, Jiao Ye, Halizere Simayi et autres

Background: Colorectal cancer (CRC) is one of the most common cancers worldwide and is related to diet and obesity. Currently, crosstalk between lipid metabolism and CRC has been reported; however, the specific mechanism is not yet understood. In this study, we screened …

cn (code pays fourni par la source)

Inhibition of Posterior Capsule Opacification by Adenovirus-Mediated Delivery of Short Hairpin RNAs Targeting TERT in a Rabbit Model

Na He, Xiangxiang Zhang, Peiling Xie, Jialing He et autres

PURPOSE: Posterior capsule opacification (PCO) is the most common postoperative complication after cataract surgery and cannot yet be eliminated. Here, we investigated the inhibitory effects of telomerase reverse transcriptase (TERT) gene silencing on PCO in a rabbit model. METHODS: After rabbit lens …

cn (code pays fourni par la source)

Single nucleotide polymorphism-based microarray analysis for the diagnosis of hydatidiform moles

Yingjun Xie, Xiaojuan Pei, Yu Dong, Huiqun Wu et autres

In clinical diagnostics, single nucleotide polymorphism (SNP)-based microarray analysis enables the detection of copy number variations (CNVs), as well as copy number neutral regions, that are absent of heterozygosity throughout the genome. The aim of the present study was to evaluate the …

cn (code pays fourni par la source)

Porcine Circovirus Type 2 the Novel ORF4 Protein Encoded by Identification and Functional Analysis of

Jiyong Zhou, Jialing He, Jingjing Cao, Niu Zhou et autres

Identification and Functional Analysis of the Novel ORF4 Protein Encoded by Porcine Circovirus Type 2

Jialing He, Jingjing Cao, Niu Zhou, Yulan Jin et autres

Porcine circovirus type 2 (PCV2) is the primary causative agent of porcine circovirus-associated diseases in pigs. To date, viral proteins Cap, Rep, Rep', and ORF3, encoded by the PCV2 genome, have been described. Here, transcription and translation of a novel viral gene …

cn (code pays fourni par la source)

Analysis of Putative ORF3 Gene Within Porcine Circovirus Type 2

Jialing He, Dan Dai, Niu Zhou, Jiyong Zhou

Porcine circovirus type 2 (PCV2) is associated with postweaning multisystemic syndrome in pigs, whereas the ubiquitous related porcine circovirus type 1 (PCV1) is nonpathogenic. Corroborating an earlier observation in PCV2, Rep and Rep' proteins encoded by ORF1 are essential for the initiation …

cn (code pays fourni par la source)

Differential Proteome Analysis of Host Cells Infected with Porcine Circovirus Type 2

Xin Zhang, Jiyong Zhou, Yongping Wu, Xiaojuan Zheng et autres

Porcine circovirus type 2 (PCV2) is the primary causative agent of postweaning multisystemic wasting syndrome, which is an emerging swine immunosuppressive disease. To uncover cellular protein responses in PCV2-infected PK-15 cells, the comprehensive proteome profiles were analyzed utilizing two-dimensional gel electrophoresis (2-DE) …

cn (code pays fourni par la source)

Interference of porcine circovirus type 2 ORF2 immunogenicity by ORF1 and ORF3 mixed DNA immunizations in mice

Zhi‐Gang She, Jiyong Zhou, Xin Zhang, Jialing He et autres

cn (code pays fourni par la source)

Characterization of Monoclonal Antibody Against Replication-Associated Protein of Porcine Circovirus

Xin Zhang, Guangpeng Ma, Yifei Li, Xuetao Jiang et autres

The replication-associated (Rep) protein of porcine circovirus (PCV) was suggested to play an essential role in the replication and translation of viral DNA. In this study, one monoclonal antibody (mAb) specific for Rep protein of porcine circovirus type 1 (PCV1), two mAbs …

lv, cn (code pays fourni par la source)

Protective immunity against porcine circovirus 2 by vaccination with ORF2-based DNA and subunit vaccines in mice

Zhi‐Gang She, Jiyong Zhou, Junqing Guo, Gang Xing et autres

The protective immune response against porcine circovirus 2 (PCV2) infection in mice was characterized using flow cytometric analysis (FCM), assays of antibody (of different IgG isotypes) and viraemia, and histopathological examination. An open reading frame 2 plasmid (pORF2) and the capsid protein …

cn (code pays fourni par la source)