Expression profiles and gene set enrichment analysis of the transcriptomes from the cancer tissue, white adipose tissue and paracancer tissue with colorectal cancer
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Le résumé fourni par la source
Background: Colorectal cancer (CRC) is one of the most common cancers worldwide and is related to diet and obesity. Currently, crosstalk between lipid metabolism and CRC has been reported; however, the specific mechanism is not yet understood. In this study, we screened differentially expressed long non-coding RNAs (lncRNAs) and mRNAs from primary cancer, paracancer, and white adipose tissue of CRC patients. We screened and analyzed the genes differentially expressed between primary and paracancer tissue and between paracancer and white adipose tissue but not between primary and white adipose tissue. According to the results of the biological analysis, we speculated a lncRNA (MIR503HG) that may be involved in the crosstalk between CRC and lipid metabolism through exosome delivery. Methods: We screened differentially expressed long non-coding RNAs (lncRNAs) and mRNAs from primary cancer, paracancer, and white adipose tissue of CRC patients. We screened and analyzed the genes differentially expressed between primary and paracancer tissue and between paracancer and white adipose tissue but not between primary and white adipose tissue. Results: We speculated a lncRNA (MIR503HG) that may be involved in the crosstalk between CRC and lipid metabolism through exosome delivery. Conclusions: In this study, the findings raise the possibility of crosstalk between lipid metabolism and CRC through the exosomal delivery of lncRNAs.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Expression profiles and gene set enrichment analysis of the transcriptomes from the cancer tissue, white adipose tissue and paracancer tissue with colorectal cancer
- Date Crossref
- 29/03/2024
- Éditeur
- PeerJ
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Zhejiang University Department of Colorectal Surgery and Oncology (Key Laboratory of Cancer Prevention and Intervention pays non établi dans la noticeUniversité ou école supérieure
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Affiliated Hospital of Hangzhou Normal University Affiliated XiaoShan Hospital pays non établi dans la noticeÉtablissement de santé
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Children's Hospital of Zhejiang University pays non établi dans la noticeÉtablissement de santé
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School of Public Health Chronic Disease Research Institute pays non établi dans la noticeUniversité ou école supérieure
Department of Colorectal Surgery and Oncology (Key Laboratory of Cancer Prevention and Intervention — Zhejiang University, Affiliated XiaoShan Hospital — Affiliated Hospital of Hangzhou Normal University et Children's Hospital of Zhejiang University, avec 1 autre affiliation.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.