Tin Maung Hlaing

Emergence of Novel Human Infections: New Insights and New Challenges

Chit Su Tinn, Tin Maung Hlaing, Bang‐on Thepthien

gb, mm, th (code pays fourni par la source)

Prevalence of G6PD deficiency and diagnostic accuracy of a G6PD point-of-care test among a population at risk of malaria in Myanmar

Than Htike Aung, Chayanut Suansomjit, Zaw Min Tun, Tin Maung Hlaing et autres

BACKGROUND: Over the past decade, the incidence of malaria has steadily declined in Myanmar, with Plasmodium vivax becoming predominant. The resilience of P. vivax to malaria control is attributed to the parasite's ability to form hypnozoites in the host's liver, which can …

th, mm, us (code pays fourni par la source)

Temporal Dynamics of Subclinical Malaria in Different Transmission Zones of Myanmar

Joseph R. Egger, Kay Thwe Han, Huang Fang, Xiao Zhou et autres

Countries in the Greater Mekong Subregion have committed to eliminate Plasmodium falciparum malaria by 2025. Subclinical malaria infections that can be detected by highly sensitive polymerase chain reaction (PCR) testing in asymptomatic individuals represent a potential impediment to this goal, although the …

us, mm, cn (code pays fourni par la source)

Genetic surveillance in the Greater Mekong subregion and South Asia to support malaria control and elimination

Christopher G. Jacob, Thuy-Nhien Nguyen, Mayfong Mayxay, Richard J. Maude et autres

Background: National Malaria Control Programmes (NMCPs) currently make limited use of parasite genetic data. We have developed GenRe-Mekong, a platform for genetic surveillance of malaria in the Greater Mekong Subregion (GMS) that enables NMCPs to implement large-scale surveillance projects by integrating simple …

gb, vn, la, us, th, kh, bd, ch, République démocratique du Congo, fr, mm, in (code pays fourni par la source)

Author response: Genetic surveillance in the Greater Mekong subregion and South Asia to support malaria control and elimination

Christopher G. Jacob, Thuy-Nhien Nguyen, Mayfong Mayxay, Richard J. Maude et autres

gb, vn, la, kh, Somalie, us, th, bd, pk, ch, République démocratique du Congo, fr, mm, ca, in, nl (code pays fourni par la source)

Prevalence of pharmacogenomic variants in 100 pharmacogenes among Southeast Asian populations under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm)

Chakkaphan Runcharoen, Koya Fukunaga, Insee Sensorn, Nareenart Iemwimangsa et autres

Pharmacogenomics can enhance the outcome of treatment by adopting pharmacogenomic testing to maximize drug efficacy and lower the risk of serious adverse events. Next-generation sequencing (NGS) is a cost-effective technology for genotyping several pharmacogenomic loci at once, thereby increasing publicly available data. …

th, jp, vn, mm, my, ph, ae, id, us, gr, gb (code pays fourni par la source)

Genetic surveillance in the Greater Mekong Subregion and South Asia to support malaria control and elimination

Christopher G. Jacob, Thuy-Nhien Nguyen, Mayfong Mayxay, Richard J. Maude et autres

ABSTRACT National Malaria Control Programmes (NMCPs) currently make limited use of parasite genetic data. We have developed GenRe-Mekong, a platform for genetic surveillance of malaria in the Greater Mekong Subregion (GMS) that enables NMCPs to implement large-scale surveillance projects by integrating simple …

gb, vn, la, Somalie, us, th, kh, bd, ch, République démocratique du Congo, fr, mm, in (code pays fourni par la source)

Molecular epidemiology of resistance to antimalarial drugs in the Greater Mekong subregion: an observational study

Mallika Imwong, Mehul Dhorda, Kyaw Myo Tun, Aung Myint Thu et autres

BACKGROUND: The Greater Mekong subregion is a recurrent source of antimalarial drug resistance in Plasmodium falciparum malaria. This study aimed to characterise the extent and spread of resistance across this entire region between 2007 and 2018. METHODS: P falciparum isolates from Myanmar, …

th, mm, gb, la, kh (code pays fourni par la source)

Triple artemisinin-based combination therapies versus artemisinin-based combination therapies for uncomplicated Plasmodium falciparum malaria: a multicentre, open-label, randomised clinical trial

Rob W. van der Pluijm, Rupam Tripura, Richard M. Hoglund, Aung Pyae Phyo et autres

BACKGROUND: Artemisinin and partner-drug resistance in Plasmodium falciparum are major threats to malaria control and elimination. Triple artemisinin-based combination therapies (TACTs), which combine existing co-formulated ACTs with a second partner drug that is slowly eliminated, might provide effective treatment and delay emergence …

th, nl, gb, mm, kh, in, République démocratique du Congo, vn, us, la, bd (code pays fourni par la source)

Genomic structure and diversity of Plasmodium falciparum in Southeast Asia reveal recent parasite migration patterns

Amol C. Shetty, Christopher G. Jacob, Fang Huang, Yao Li et autres

Estimates of Plasmodium falciparum migration may inform strategies for malaria elimination. Here we elucidate fine-scale parasite population structure and infer recent migration across Southeast Asia using identity-by-descent (IBD) approaches based on genome-wide single nucleotide polymorphisms called in 1722 samples from 54 districts. …

us, gb, cn, th, ch, mm, at, bd, la, vn, Nigéria (code pays fourni par la source)

Southeast Asian Pharmacogenomics Research Network (SEAPharm): Current Status and Perspectives

Supatat Chumnumwat, Zen Huat Lu, Chonlaphat Sukasem, Michael D. Winther et autres

Pharmacogenomics (PGx) is increasingly being recognized as a potential tool for improving the efficacy and safety of drug therapy. Therefore, several efforts have been undertaken globally to facilitate the implementation process of PGx into routine clinical practice. Part of these efforts include …

th, bn, sg, ph, np, vn, my, id (code pays fourni par la source)

Supplementary Material for: Southeast Asian Pharmacogenomics Research Network (SEAPharm): Current Status and Perspectives

Supatat Chumnumwat, Zen Huat Lu, Chonlaphat Sukasem, Michael D. Winther et autres

Pharmacogenomics (PGx) is increasingly being recognized as a potential tool for improving the efficacy and safety of drug therapy. Therefore, several efforts have been undertaken globally to facilitate the implementation process of PGx into routine clinical practice. Part of these efforts include …