Temporal Dynamics of Subclinical Malaria in Different Transmission Zones of Myanmar
Rattachement africain : us, mm, cn. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Countries in the Greater Mekong Subregion have committed to eliminate Plasmodium falciparum malaria by 2025. Subclinical malaria infections that can be detected by highly sensitive polymerase chain reaction (PCR) testing in asymptomatic individuals represent a potential impediment to this goal, although the extent to which these low-density infections contribute to transmission is unclear. To understand the temporal dynamics of subclinical malaria in this setting, a cohort of 2,705 participants from three epidemiologically distinct regions of Myanmar was screened for subclinical P. falciparum and P. vivax infection using ultrasensitive PCR (usPCR). Standard rapid diagnostic tests (RDTs) for P. falciparum were also performed. Individuals who tested positive for malaria by usPCR were followed for up to 12 weeks. Regression analysis was performed to estimate whether the baseline prevalence of infection and the count of repeated positive tests were associated with demographic, behavioral, and clinical factors. At enrollment, the prevalence of subclinical malaria infection measured by usPCR was 7.7% (1.5% P. falciparum monoinfection, 0.3% mixed P. falciparum and P. vivax, and 6.0% P. vivax monoinfection), while P. falciparum prevalence measured by RDT was just 0.2%. Prevalence varied by geography and was higher among older people and in those with outdoor exposure and travel. No difference was observed in either the prevalence or count of subclinical infection by time of year, indicating that even in low-endemicity areas, a reservoir of subclinical infection persists year-round. If low-density infections are shown to represent a significant source of transmission, identification of high-risk groups and locations may aid elimination efforts.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Temporal Dynamics of Subclinical Malaria in Different Transmission Zones of Myanmar
- Date Crossref
- 14/09/2022
- Éditeur
- American Society of Tropical Medicine and Hygiene
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Duke University Duke Global Health Institute pays non établi dans la noticeUniversité ou école supérieure
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Duke Institute for Health Innovation pays non établi dans la noticeInstitution
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Ministry of Health and Sports Department of Medical Research pays non établi dans la noticeOrganisme public
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Ministry of Health pays non établi dans la noticeOrganisme public
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National Institute for Parasitic Diseases pays non établi dans la noticeOrganisme public
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Zhejiang Center for Disease Control and Prevention pays non établi dans la noticeOrganisme public
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Pharmaceutical Product Development (United States) pays non établi dans la noticeEntreprise
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University of Maryland Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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National Institute of Parasitic Diseases pays non établi dans la noticeStructure de recherche
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Zhejiang Provincial Center for Disease Control and Prevention pays non établi dans la noticeInstitution
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Defense Services Medical Research Center pays non établi dans la noticeStructure de recherche
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PPD pays non établi dans la noticeInstitution
Duke Global Health Institute — Duke University, Duke Institute for Health Innovation et Department of Medical Research — Ministry of Health and Sports, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.