Y Leung

Differential Preclinical Efficacy of Combined CDK4/6 and MEK Inhibition in Low-Grade Serous Ovarian Carcinoma Based on KRAS/NF1 Mutational Status

Madison Bittner, Marta Llauradó Fernández, Joshua Hoenisch, Y Leung et autres

Low-grade serous ovarian carcinoma (LGSOC) usually presents in advanced stages and is associated with a high mortality rate. Clinical trials targeting the MAPK and cell cycle pathways in LGSOC have shown promising results for its treatment, however there is a need to …

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Differential Preclinical Efficacy of Combined CDK4/6 and MEK Inhibition in Low-Grade Serous Ovarian Carcinoma Based on KRAS/NF1 Mutational Status

Madison Bittner, Marta Llaurado Fernandez, Joshua Hoenisch, Y Leung et autres

Low-grade serous ovarian carcinoma (LGSOC) usually presents in advanced stages and is associated with a high mortality rate. Clinical trials targeting the MAPK and cell cycle pathways in LGSOC have shown promising results for its treatment, however there is a need to …

P1212 Effectiveness of Vedolizumab to Reduce Bowel Urgency in a Canadian Real-World Ulcerative Colitis Cohort

Robert J. Battat, Y Leung, Parul Tandon, Robert Edwin Ward et autres

Abstract Background Vedolizumab is a gut-selective anti-lymphocyte trafficking drug indicated for the treatment of moderately to severely active ulcerative colitis (UC). Bowel urgency, the immediate or sudden need to have a bowel movement, is a common symptom in UC, that reduces quality …

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P1232 A Novel Inflammatory Bowel Disease Registry Powered by Artificial Intelligence and Natural Language Processing

Jianzhong Liu, Camila da Silveira Massaro, Eduardo M. da Cruz, Itay Kalisky et autres

Abstract Background Accurate data registries may assist clinicians and researchers to gain insights into inflammatory bowel disease(IBD) and provide opportunities to improve overall patient care. However, most data registries are limited by the amount of time needed to collect and record patient-level …

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DOP009 Effectiveness and Safety of Advanced Combination Treatment (ACT) in patients with refractory inflammatory bowel disease or concomitant immune mediated disease or extra-intestinal manifestations: A Multi-Center Canadian Study

Virginia Solitano, Ropo Ebenezer Ogunsakin, Yuhong Yuan, Charles Noah Bernstein et autres

Abstract Background Some patients with inflammatory bowel disease (IBD) do not respond to multiple advanced therapies, resulting in off-label use of two advanced therapeutic agents, known as advanced combination treatment (ACT) (1). Methods This multi-center study in 9 Canadian centers included adult …

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FOLR1 as a therapeutic target in platinum-resistant ovarian carcinoma: unique expression patterns across ovarian carcinoma histotypes and molecular subtypes of low-grade serous carcinoma

Y Leung, Marta Llauradó Fernández, Anna Cameron, Annalyn Da-Anoy et autres

OBJECTIVE: With the development of novel antibody-drug conjugates (ADCs), folate receptor alpha (FOLR1) is a promising therapeutic target for the treatment of platinum-resistant tubo-ovarian carcinomas. The main aims of this study were to assess FOLR1 protein expression in a large cohort of …

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A175 REAL-WORLD EXPERIENCE ON SWITCHING FROM ADALIMUMAB TO BIOSIMILARS IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE – AN OBSERVATIONAL STUDY FROM THREE TERTIARY CARE CENTRES

Harjot K. Bedi, Daniel Eli Cohen Rosenfeld, Thomas Tam Hoang, M Reise-Filteau et autres

Abstract Background Inflammatory Bowel Disease (IBD) is a chronic inflammatory condition of the bowel which includes ulcerative colitis (UC), Crohn’s disease (CD) or unspecific IBD (IBDu). Adalimumab (ADA), a humanized monoclonal IgG antibody against tumour necrosis factor-alpha (TNFa), is an effective treatment …

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A200 HIGH-DEFINITION CHROMOENDOSCOPY RESULTS IN MORE SIGNIFICANT DYSPLASIA DETECTION THAN WHITE LIGHT ENDOSCOPY WITH RANDOM BIOPSIES IN ULCERATIVE COLITIS PATIENTS

Thomas Tam Hoang, Y Leung, Greg A Rosenfeld, B Bressler

Abstract Background Ulcerative colitis (UC) is an inflammatory bowel disease that results in inflammation of the colonic mucosa, leading to abdominal pain, rectal bleeding, weight loss, and diarrhea. This chronic inflammation results in a 2.4-fold increased future risk of developing colorectal cancer …

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DOP41 Achievement of corticosteroid-free clinical endpoints in subjects with ulcerative colitis: an analysis of the phase 3 ELEVATE UC 52 trial

B E Sands, David T. Rubin, Julián Panés, Krisztina Barbara Gecse et autres

Abstract Background Achievement of corticosteroid (CS)-free remission is an important long-term outcome in ulcerative colitis (UC). Etrasimod is an investigational, once-daily, oral, selective sphingosine 1-phosphate receptor 1,4,5 (S1P1,4,5) modulator in development for the treatment of moderately to severely active UC. This analysis …

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518. VATS ESOPHAGEAL DIVERTICULECTOMY WITH LAPAROSCOPIC HELLER MYOTOMY AND DOR FUNDOPLICATION

Siu Hong Cheung, Y Leung, Choi Kwan So, Tiffany Wing Ka Wong et autres

Abstract 60years old lady presented with dysphagia. Upper endoscopy found a large esophageal diverticulum at distal esophagus which was the likely cause of symptoms. Diverticulectomy was suggested in view of its large size and symptoms. Video assisted thoroscopic surgery was utilized in …

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Discovering and harnessing oxidative enzymes for chemoenzymatic synthesis and diversification of anticancer camptothecin analogues

Tuan‐Anh Minh Nguyen, Trinh‐Don Nguyen, Y Leung, Matthew McConnachie et autres

Semi-synthetic derivatives of camptothecin, a quinoline alkaloid found in the Camptotheca acuminata tree, are potent anticancer agents. Here we discovered two C. acuminata cytochrome P450 monooxygenases that catalyze regio-specific 10- and 11-oxidations of camptothecin, and demonstrated combinatorial chemoenzymatic C-H functionalizations of the …

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Tumoral Calcinosis: A Case Report

Y Leung, Raymond W. M. Lai

An 11-year-old girl presented with a progressive swelling of the right elbow after a contusion. Radiography and magnetic resonance imaging showed a densely calcified lesion with no periosteal reaction or fracture. The underlying bone and muscles had normal signal intensity. A bone …

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