Sylvain Etter

Dietary administration of α-terpineol to Sprague-Dawley rats for 90 days

M Aubanel, Christopher Y. Choi, Jan Demyttenaere, Maodo Malick Diop et autres

α-Terpineol is a flavoring ingredient that occurs naturally in spices and foods. It has been evaluated by regulatory and scientific expert bodies such as the Joint FAO/WHO Expert Committee on Food Additives (JECFA) in 1999 and the European Food Safety Authority (EFSA) …

ie, us, be, fr, ch, sg, jp, de (code pays fourni par la source)

Assessment of no-observed-effect-levels for DNA adducts formation by genotoxic carcinogens in fetal turkey livers

Tetyana Kobets, Christina Hickey, George E. Johnson, Jian‐Dong Duan et autres

us, gb, ch (code pays fourni par la source)

Repeated dose toxicity study to assess the safety and reproductive/developmental safety of 7-methyl-2H-1,5-Benzodioxepin-3(4H)-One (Calone®) and the read across approach to its biodegradation metabolite 7-methyl-2H-1,5-benzodioxepin-3-ol (Calol)

Hanghui Liu, Lily Ida, Anthony A. Birkbeck, Tiina A. Lantto et autres

us, ch, be (code pays fourni par la source)

The BlueScreen HC assay to predict the genotoxic potential of fragrance materials

Yax Thakkar, Kaushal Joshi, Christina Hickey, J. Wahler et autres

BlueScreen HC is a mammalian cell-based assay for measuring the genotoxicity and cytotoxicity of chemical compounds and mixtures. The BlueScreen HC assay has been utilized at the Research Institute for Fragrance Materials in a safety assessment program as a screening tool to …

us, ch, sg, de, gb, fr (code pays fourni par la source)

A chemical structure-based approach for estimating the added levels of flavourings to foods for the purpose of assessing consumer intake

Maria Bastaki, M Aubanel, Heidi Bialk, Christopher Y. Choi et autres

Intake assessment and hazard profile of chemical substances are the two critical inputs in a safety assessment. Human intake assessment presents challenges that stem either from the absence of data or from numerous sources of variability and uncertainty, which have led regulators …

us, fr, ch, de (code pays fourni par la source)

Absence of mutagenic activity in the bacterial reverse mutation assay with pulegone and peppermint oil

Maria Bastaki, Vivian Lu, M Aubanel, Heidi Bialk et autres

The essential oil of peppermint and one of its natural constituents, (R)-(+)-pulegone, are approved flavorings added to food worldwide. (R)-(+)-Pulegone and peppermint oil were tested separately in two independent bacterial reverse mutation assays according to Organisation for Economic Co-operation and Development Guideline …

us, fr, ch, de (code pays fourni par la source)

A chemical structure-based approach for estimating the added levels of flavourings to foods for the purpose of assessing consumer intake

Maria Bastaki, M Aubanel, Heidi Bialk, Christopher Y. Choi et autres

Intake assessment and hazard profile of chemical substances are the two critical inputs in a safety assessment. Human intake assessment presents challenges that stem either from the absence of data or from numerous sources of variability and uncertainty, which have led regulators …

cn (code pays fourni par la source)

2,4-Decadienal does not induce genotoxic effects in in vivo micronucleus studies

Maria Bastaki, Vivian Lu, M Aubanel, Thierry Cachet et autres

2,4-Decadienal (E,E-) occurs naturally in foods and is also used as a flavoring ingredient. In vivo micronucleus studies were used to evaluate the potential for 2,4-decadienal to cause genotoxic effects. Male Han Wistar rats were dosed either by intraperitoneal injection or by …

us, fr, ch, jp, gb, de (code pays fourni par la source)

Making reliable negative predictions of human skin sensitisation using an in silico fragmentation approach

Martyn L. Chilton, Donna S. Macmillan, Thomas Steger‐Hartmann, Jedd Hillegass et autres

gb, de, us, ch, be (code pays fourni par la source)

In ovo testing of flavor and fragrance materials in Turkey Egg Genotoxicity Assay (TEGA), comparison of results to in vitro and in vivo data

Tetyana Kobets, Jian‐Dong Duan, Klaus D. Brunnemann, Michael J. Iatropoulos et autres

us (code pays fourni par la source)

A quantitative in silico model for predicting skin sensitization using a nearest neighbours approach within expert‐derived structure–activity alert spaces

Steven J. Canipa, Martyn L. Chilton, Rachel Hemingway, Donna S. Macmillan et autres

Dermal contact with chemicals may lead to an inflammatory reaction known as allergic contact dermatitis. Consequently, it is important to assess new and existing chemicals for their skin sensitizing potential and to mitigate exposure accordingly. There is an urgent need to develop …

gb, de, nl, us, ch, be (code pays fourni par la source)

Structure-Activity Relationships for DNA Damage by Alkenylbenzenes in Turkey Egg Fetal Liver

Tetyana Kobets, Jian‐Dong Duan, Klaus D. Brunnemann, Sylvain Etter et autres

Certain alkenylbenzenes (AB), flavoring chemicals naturally occurring in spices and herbs, are established to be cytotoxic and hepatocarcinogenic in rodents. The purpose of the present study was to determine the DNA damaging potential of key representatives of this class using the Turkey …

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