Kunimoto Hotta

Highly purified hypochlorous acid water facilitates glucose metabolism and memory formation in type 2 diabetic mice associated with altered-gut microbiota

Kazuki Watanabe, Yusuke Maruyama, Risako Mikami, Keiji Komatsu et autres

Hypochlorous acid (HOCl) is an endogenous oxidant and chlorinating agent in mammals that is effective against a broad range of microorganisms. However, the effects of exogenous HOCl on biological processes have not been reported. In this study, the effects of highly purified …

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Electrolyzed hypochlorous acid water exhibits potent disinfectant activity against various viruses through irreversible protein aggregation

Rahmi dianty, Junki Hirano, Itsuki Anzai, Yuta Kanai et autres

It is essential to employ efficient measures to prevent the transmission of pathogenic agents during a pandemic. One such method involves using hypochlorous acid (HClO) solution. The oxidative properties of HClO water (HAW) can contribute to its ability to eliminate viral particles. …

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Basic and applied research on multiple aminoglycoside antibiotic resistance of actinomycetes: an old-timer's recollection

Kunimoto Hotta

A list of our research achievements on multiple aminoglycoside antibiotic (AG) resistance in AG-producing actinomycetes is outlined. In 1979, the author discovered a novel AG (istamycin)-producing Streptomyces tenjimariensis SS-939 by screening actinomycetes with kanamycin (KM)-resistance and plasmid profiles. This discovery directed our …

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論と証拠の質

Kunimoto Hotta

The Evaluation of Neutralizing effects of Alkaline Electrolyzed Water Rinsing

Tokura Shiori, Tozawa Hinako, Watanabe Mika, Yoshinori Tanaka et autres

Kanamycin and its derivative, arbekacin: significance and impact

Kunimoto Hotta, Shinichi Kondo

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Preface for the Special Issue dedicated to Professor Julian E. Davies

Kunimoto Hotta, Morimasa Yagisawa

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Epoch-making milestones in antibiotic exploratory researches in Japan†

Kunimoto Hotta

Professor Satoshi Ōmura was awarded the 2015 Nobel Prize in Physiology or Medicine. He is the third to win the award for research on antibiotic, following Fleming' (UK, 1945, discovery of penicillin) and Waksman (USA, 1952, discovery of streptomycin), and the second …

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Titre indisponible

Kunimoto Hotta

[A historical story of the Japanese antibiotics world-development of penicillin].

Kunimoto Hotta

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Structure-Activity Relationship Study of 8-amino-2,8-dideoxy-β -KDO, a Potent CMP-KDO Synthetase Inhibitor

Hayamitsu Adachi, Ken-ichiro Kondo, Fukiko Kojima, Yōji Umezawa et autres

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Bispolides, Novel 20-Membered Ring Macrodiolide Antibiotics from Microbispora

Noriyuki Okujo, Hironobu Iinuma, Annie George, Khor Siew Eim et autres

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