R. Pai

PP153 A randomized, open-label phase ii study comparing a novel regimen of dose-dense docetaxel-cyclophosphamide alternating with epirubicin-cisplatin against anthracycline-taxane in early TNBC, stratified for the use of low-dose nivolumab (NEOPLANETx study)

Josh Thomas Georgy, A. Joel, Deepa Susan Joy Philip, D.B. Thumaty et autres

Recent advances in early triple-negative breast cancer (TNBC) treatment have incorporated immune checkpoint inhibitors and carboplatin, notably in the KEYNOTE-522 trial, enhancing pathological complete response (pCR) and event-free survival. However, consistent benefits in overall survival are unclear, and carboplatin regimens often cause …

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EPV120/#399 Endometrial cancer: molecular analysis and clinicopathological correlation: a pilot study

Arun Dahiya, Appu Thomas, R. Pai, Samantha Daniel et autres

Objectives Aim/Introduction: Limited reproducibility and imprecise risk estimation of traditional classification have paved the way for molecular research in endometrial cancer. The study aims to determine the prevalence of Polymerase Epsilon gene (POLE) mutation, P53 mutations, and microsatellite instability (MSI) in endometrial …

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Clinicopathologic features of non-small cell lung cancer in India and correlation with epidermal growth factor receptor mutational status

AD Bhatt, R. Pai, G. Rebekah, S Dhananjayan et autres

INTRODUCTION: We performed retrospective analysis of 106 patients with lung cancer for which formalin-fixed paraffin-embedded tissues was available. Their epidermal growth factor receptor (EGFR) mutation status and treatment outcomes are described. MATERIALS AND METHODS: All patients with confirmed non-small cell lung cancer …

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Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate.

R. Pai, R.M. Lalitha, Seema Pai, Sudhir Goppenahalli Kumaraswamy et autres

AIM: The present study was directed on the assessment of the response of treatment-naive oral cancer cells to methotrexate (MTX) in vitro: and clinical response to MTX therapy. METHODS: A pilot study of in vitro: evaluation of MTX response of oral cancer …

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Overexpression of c-Myc oncoprotein in oral squamous cell carcinoma in the south Indian population

R. Pai

Oral neoplasm constitutes a predominant class of cancer that is encountered in South India. This is in large part due to the elevated risk of oncogenesis as a result of the habit of chewing of quids containing betel leaves, areca nut and …

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Expression of oncofoetal marker carcinoembryonic antigen in oral cancers in South India—a pilot study

S. Balakrishna Pai, R. Pai, R.M. Lalitha, S.V. Kumaraswamy et autres

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Overexpression and co-localization of Cox2, ErbB2/B3 and B-catenin in the invasive margin of gastric cancers: A key to cancer growth and progression?

Jing Yang, Woo‐Sung Moon, R. Pai, Andrzej S. Tamawski

The origin of the cancer cell: oncogeny reverses phylogeny

Randal N. Johnston, S. Balakrishna Pai, R. Pai

The formulation in 1874 of the biogenetic law by Ernst Haeckel as "ontogeny recapitulates phylogeny" emphasized the structural similarities detected in metazoans between their developmental and ancestral forms. More recently, many workers have independently commented on the similarities observed between the behaviours …

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