Solenne Taront

Derepression of the epithelial transcription factor GRHL2 promotes direct hepatocyte-to-cholangiocyte transdifferentiation

Ludivine Vasseur, Céline Gheeraert, Julie Dubois‐Chevalier, Ninon Very et autres

The liver's regenerative capacity is underscored by the plasticity potential of adult hepatocytes. In this context, hepatocyte-to-cholangiocyte transdifferentiation (HCT) has been ascribed with pro-regenerative functions in animal models and is a feature of end-stage human chronic liver diseases. While dampened activities of …

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Alcohol-related hepatitis induces a specific fibrosis profile through YAP activation in myofibroblasts

Line Carolle Ntandja Wandji, Mohamed Bou Saleh, Cyril Sobolewski, Mehdi El Amrani et autres

Background & Aims YAP impairs hepatocyte regeneration in alcohol-related hepatitis (AH), but its impact on fibrogenesis remains to be characterized. Our aim was to describe fibrogenesis and investigate the impact of altered hepatocytes on fibrogenic mechanisms during AH. Methods Fibrosis, YAP and …

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Dimerization of kringle 1 domain from hepatocyte growth factor/scatter factor provides a potent MET receptor agonist

Giovanni de Nola, B. Leclercq, Alexandra Mougel, Solenne Taront et autres

Hepatocyte growth factor/scatter factor (HGF/SF) and its cognate receptor MET play several essential roles in embryogenesis and regeneration in postnatal life of epithelial organs such as the liver, kidney, lung, and pancreas, prompting a strong interest in harnessing HGF/SF-MET signalling for regeneration …

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Exposure of Caenorhabditis elegans to Dietary Nε-Carboxymethyllysine Emphasizes Endocytosis as a New Route for Intestinal Absorption of Advanced Glycation End Products

Constance Dubois, Rachel Litke, Stéphane Rianha, Charles Paul-Constant et autres

The impact of dietary advanced glycation end products (dAGEs) on human health has been discussed in many studies but, to date, no consensual pathophysiological process has been demonstrated. The intestinal absorption pathways which have so far been described for dAGEs, the passive …

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Dimerization of kringle 1 domain from hepatocyte growth factor/scatter factor provides a potent minimal MET receptor agonist

Giovanni de Nola, B. Leclercq, Alexandra Mougel, Solenne Taront et autres

Abstract Hepatocyte Growth Factor/Scatter Factor (HGF/SF) and its cognate receptor MET play several essential roles in embryogenesis and regeneration in post-natal life of epithelial organs such as liver, kidney, lung, and pancreas, prompting a strong interest in harnessing HGF/SF-MET signalling for regeneration …

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Chapter Three Involvement of the rage-ligand axis in aging

Thibault Teissier, Rachel Litke, Solenne Taront, Steve Lancel et autres

International audience

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PD-1/PD-L1 binding studies using microscale thermophoresis

Romain Magnez, Bryan Thiroux, Solenne Taront, Zacharie Segaoula et autres

The characterization of protein interactions has become essential in many fields of life science, especially drug discovery. Microscale thermophoresis (MST) is a powerful new method for the quantitative analysis of protein-protein interactions (PPIs) with low sample consumption. In addition, one of the …

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Beneficial Metabolic Effects of Rapamycin Are Associated with Enhanced Regulatory Cells in Diet-Induced Obese Mice

Kassem Makki, Solenne Taront, Olivier Molendi‐Coste, Emmanuel Bouchaert et autres

The "mechanistic target of rapamycin" (mTOR) is a central controller of growth, proliferation and/or motility of various cell-types ranging from adipocytes to immune cells, thereby linking metabolism and immunity. mTOR signaling is overactivated in obesity, promoting inflammation and insulin resistance. Therefore, great …

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A Structural Explanation of the Effects of Dissociated Glucocorticoids on Glucocorticoid Receptor Transactivation

Xavier Dezitter, Jérôme Fagart, Solenne Taront, Michel Fay et autres

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Réduction de masse grasse, leptine et interleukine 7 (IL-7) sous sirolimus chez l’homme : de la transplantation aux lipodystrophies ?

E. Parent, Isabelle Wolowczuk, Wassila Karrouz, Solenne Taront et autres

La leptine, produit protéique du gène Ob, est synthétisée dans le placenta à des taux comparables à ceux de la cellule adipeuse. La leptine placentaire est libérée principalement dans la circulation maternelle où sa concentration devient maximale au deuxième trimestre de la …

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A novel murine model of rhinoscleroma identifies Mikulicz cells, the disease signature, as IL‐10 dependent derivatives of inflammatory monocytes

Cindy Fèvre, Ana S. Almeida, Solenne Taront, Thierry Pédron et autres

Rhinoscleroma is a human specific chronic disease characterized by the formation of granuloma in the airways, caused by the bacterium Klebsiella pneumoniae subspecies rhinoscleromatis, a species very closely related to K. pneumoniae subspecies pneumoniae. It is characterized by the appearance of specific …

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O68 La rapamycine augmente la réponse inflammatoire et l’émergence des cellules « Myeloïd-derived Suppressor Cells » (MDSC) chez la souris obèse

Karim Makki, Solenne Taront, Bernadette Neve, Emmanuel Bouchaert et autres

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