Alexandra Mougel

Total synthesis and structural characterization of a novel protein scaffold from the snail Biomphalaria glabrata

Oleg Melnyk, Stéphanie Caby, Armelle Vigouroux, Christine Demanche et autres

Disulfide-rich miniproteins constitute compact and highly stable scaffolds of growing interest for molecular and structural engineering. Schistosomins are ~80-residue proteins conserved across gastropods that form a long-standing orphan family whose structure and biological roles have remained unknown. Here, we report the total …

fr (code pays fourni par la source)

Total synthesis and structural characterization of a novel protein scaffold from the snail Biomphalaria glabrata

Oleg Melnyk, Stéphanie Caby, Armelle Vigouroux, Christine Demanche et autres

Abstract Disulfide-rich miniproteins constitute compact and highly stable scaffolds of growing interest for molecular and structural engineering. Schistosomins are ∼80-residue proteins conserved across gastropods that form a long-standing orphan family whose structure and biological roles have remained unknown. Here, we report the …

fr (code pays fourni par la source)

Optimized protocols for RNA interference in Macrostomum lignano

Stijn Mouton, Alexandra Mougel, Kirill Ustyantsev, Colette Dissous et autres

Macrostomum lignano, a marine free-living flatworm, has emerged as a potent invertebrate model in developmental biology for studying stem cells, germline, and regeneration processes. In recent years, many tools have been developed to manipulate this worm and to facilitate genetic modification. RNA …

nl, fr (code pays fourni par la source)

Optimized protocols for RNA interference in Macrostomum lignano

Stijn Mouton, Alexandra Mougel, Kirill Ustyantsev, Colette Dissous et autres

Abstract Macrostomum lignano , a marine free-living flatworm, has emerged as a potent invertebrate model in developmental biology for studying stem cells, germline, and regeneration processes. In recent years, many tools have been developed to manipulate this worm and to facilitate genetic …

nl, fr (code pays fourni par la source)

Data from Nerve Growth Factor Is a Potential Therapeutic Target in Breast Cancer

Éric Adriaenssens, Elsa Vanhecke, Pasquine Saule, Alexandra Mougel et autres

Abstract We show here that nerve growth factor (NGF), the prototypic neurotrophin, can be targeted in breast cancer to inhibit tumor cell proliferation, survival, and metastasis. Analysis of a series of biopsies revealed widespread expression of NGF in the majority of human …

Supplementary Figure 3 from Nerve Growth Factor Is a Potential Therapeutic Target in Breast Cancer

Éric Adriaenssens, Elsa Vanhecke, Pasquine Saule, Alexandra Mougel et autres

Supplementary Figure 3 from Nerve Growth Factor Is a Potential Therapeutic Target in Breast Cancer

Supplementary Figure 2 from Nerve Growth Factor Is a Potential Therapeutic Target in Breast Cancer

Éric Adriaenssens, Elsa Vanhecke, Pasquine Saule, Alexandra Mougel et autres

Supplementary Figure 2 from Nerve Growth Factor Is a Potential Therapeutic Target in Breast Cancer

Supplementary Figure 1 from Nerve Growth Factor Is a Potential Therapeutic Target in Breast Cancer

Éric Adriaenssens, Elsa Vanhecke, Pasquine Saule, Alexandra Mougel et autres

Supplementary Figure 1 from Nerve Growth Factor Is a Potential Therapeutic Target in Breast Cancer

Supplementary Figure 1 from Nerve Growth Factor Is a Potential Therapeutic Target in Breast Cancer

Éric Adriaenssens, Elsa Vanhecke, Pasquine Saule, Alexandra Mougel et autres

Supplementary Figure 1 from Nerve Growth Factor Is a Potential Therapeutic Target in Breast Cancer

Supplementary Figure 2 from Nerve Growth Factor Is a Potential Therapeutic Target in Breast Cancer

Éric Adriaenssens, Elsa Vanhecke, Pasquine Saule, Alexandra Mougel et autres

Supplementary Figure 2 from Nerve Growth Factor Is a Potential Therapeutic Target in Breast Cancer

Supplementary Figure 3 from Nerve Growth Factor Is a Potential Therapeutic Target in Breast Cancer

Éric Adriaenssens, Elsa Vanhecke, Pasquine Saule, Alexandra Mougel et autres

Supplementary Figure 3 from Nerve Growth Factor Is a Potential Therapeutic Target in Breast Cancer

Data from Nerve Growth Factor Is a Potential Therapeutic Target in Breast Cancer

Éric Adriaenssens, Elsa Vanhecke, Pasquine Saule, Alexandra Mougel et autres

Abstract We show here that nerve growth factor (NGF), the prototypic neurotrophin, can be targeted in breast cancer to inhibit tumor cell proliferation, survival, and metastasis. Analysis of a series of biopsies revealed widespread expression of NGF in the majority of human …