2023
conference-abstract
OpenAlex
Jesse Green, Andrew Tucker, Aesha Vakil, Matt Scott-Skandera et autres
Fusosomes are viral vectors pseudotyped with modified paramyxovirus envelopes targeting specific cell types. A CD8-targeted fusosome delivering a CD19CAR transgene has the potential to provide an off-the-shelf therapeutic approach to generate in vivo CD19-directed chimeric antigen receptor (CAR) T cells in patients. …
us
(code pays fourni par la source)
2023
conference-abstract
OpenAlex
Hemantkumar Chavan, Shirisha Amatya, Valeria Berlfein, Patricia Cruite et autres
Autologouschimeric antigen receptor (CAR) T cells represent a groundbreaking therapy for treating B-cell malignancies. However, the complexity, cost, time and toxicity associated with manufacturing and administering current CAR T cell therapies hinder their broader applications. To overcome CAR T limitations, Sana has …
us
(code pays fourni par la source)
2023
conference-abstract
OpenAlex
Adam Johnson, Hallee Wright, Xiaomeng Hu, Jeremy M. Kinder et autres
Despite the success of CD19CAR therapy against large B-cell lymphoma, up to 60% of CD19-directed CAR T cell treated patients relapse after, or are refractory to, treatment. Of the relapsed/refractory population a significant subset of patients, around 30%, have CD19-negative tumor and …
us
(code pays fourni par la source)
2022
article
OpenAlex
Shalu Sharma Sharma, Vishal Khatri, Vasily V. Vagin, Prasanna Baskar et autres
Despite the recent success of exvivo manufactured chimeric antigen receptor (CAR) T cell therapies for treating B cell malignancies, the time-consuming manufacturing process and cost limit access. To address these limitations, a novel in vivo gene therapy platform has been developed to …
us
(code pays fourni par la source)
2021
conference-abstract
OpenAlex
Justine J. Cunningham, Sundeep Chandra, Akinola Olumide Emmanuel, Allyse Mazzarelli et autres
Abstract Introduction: Ex vivo manufactured chimeric antigen receptor (CAR) T cell therapies are highly effective for treating B cell malignancies. However, the complexity, cost and time required to manufacture CAR T cells limits access. To overcome conventional ex vivo CAR T limitations, …
us
(code pays fourni par la source)
Accès ouvert
2017
article
OpenAlex
Ian D. Peikon, Justus M. Kebschull, Vasily V. Vagin, Diana I. Ravens et autres
The function of a neural circuit is determined by the details of its synaptic connections. At present, the only available method for determining a neural wiring diagram with single synapse precision-a 'connectome'-is based on imaging methods that are slow, labor-intensive and expensive. …
us, gb
(code pays fourni par la source)
Accès ouvert
2017
preprint
OpenAlex
Ian D. Peikon, Justus M. Kebschull, Vasily V. Vagin, Diana I. Ravens et autres
Abstract The function of a neural circuit is determined by the details of its synaptic connections. At present, the only available method for determining a neural wiring diagram with single synapse precision—a “connectome”—is based on imaging methods that are slow, labor-intensive and …
us, gb
(code pays fourni par la source)
Accès ouvert
2015
preprint
OpenAlex
Kaja A. Wasik, Oliver H. Tam, Simon Knott, Ilaria Falciatori et autres
PIWI proteins and their associated piRNAs protect germ cells from the activity of mobile genetic elements. Two classes of piRNAs—primary and secondary—are defined by their mechanisms of biogenesis. Primary piRNAs are processed directly from transcripts of piRNA cluster loci, whereas secondary piRNAs …
us, gb
(code pays fourni par la source)
Accès ouvert
2014
article
OpenAlex
Oliver Meikar, Vasily V. Vagin, Frédéric Chalmel, Karin Sõstar et autres
The genome of male germ cells is actively transcribed during spermatogenesis to produce phase-specific protein-coding mRNAs and a considerable amount of different noncoding RNAs. Ribonucleoprotein (RNP) granule-mediated RNA regulation provides a powerful means to secure the quality and correct expression of the …
fi, us, fr
(code pays fourni par la source)
Accès ouvert
2013
article
OpenAlex
Vasily V. Vagin, Yang Yu, Anna Jankowska, Yicheng Luo et autres
Piwi proteins and their associated small RNAs are essential for fertility in animals. In part, this is due to their roles in guarding germ cell genomes against the activity of mobile genetic elements. piRNA populations direct Piwi proteins to silence transposon targets …
us, cn
(code pays fourni par la source)
Accès ouvert
2011
article
OpenAlex
Takashi Tanaka, Mihoko Hosokawa, Vasily V. Vagin, Eri Hayashi et autres
In the male germline in mammals, chromatoid bodies, a specialized assembly of cytoplasmic ribonucleoprotein (RNP), are structurally evident during meiosis and haploidgenesis, but their developmental origin and regulation remain elusive. The tudor domain containing proteins constitute a conserved class of chromatoid body …
jp, us, fr
(code pays fourni par la source)
Accès ouvert
2009
article
OpenAlex
Vasily V. Vagin, Gregory J. Hannon, Alexei A. Aravin
Almost all eukaryotes have small RNA pathways that regulate expression of protein-coding genes, control the activity of endogenous transposable elements and fight exogenous viral infection. Despite diversity of small RNA pathways functions and mechanisms, their core is conserved throughout evolution: it is …
us
(code pays fourni par la source)