G. Hennig

Warning criteria for MEP monitoring during carotid endarterectomy: a retrospective study of 571 patients

Michael J. Malcharek, Judith Hesse, K. Heßelbarth, Kathrin Thoma et autres

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Baroreflexaktivierungstherapie bei therapieresistenter Hypertonie

Hannes Reuter, Joachim Beige, Marcel Halbach, Manuel Wallbach et autres

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Blood pressure after blinded, randomized withdrawal, and resumption of baroreceptor-activating therapy

Joachim Beige, T Jentzsch, Ralph Wendt, G. Hennig et autres

BACKGROUND: Baroreceptor-activating therapy (BAT) has been shown to control resistant hypertension in one sham-controlled and further observational studies. Incremental but significant reincrease of blood pressure (BP) have been described after open-label temporary withdrawal of such therapy. METHOD: Our study in 16 randomized …

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Multimodal evoked potential monitoring in asleep patients versus neurological evaluation in awake patients during carotid endarterectomy: a single-centre retrospective trial of 651 patients.

Malcharek Mj, Herbst, Bartz Gj, Manceur Am et autres

BACKGROUND: A controversy exists regarding which monitoring technique is superior in cases in which general anesthesia (GA) is necessary for carotid endarterectomy (CEA). Multimodal evoked potential (mEP) monitoring was investigated under GA during CEA and compared with a historical control group undergoing …

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Baroreflex activation therapy in patients with end-stage renal failure

Joachim Beige, Michael Koziolek, G. Hennig, Amir Hamza et autres

BACKGROUND: Resistant arterial hypertension and chronic kidney disease (CKD) are interlinked via sympathetic overactivity. Baroreflex activation therapy (BAT) is a well tolerated therapy, which has been shown to reduce BP in patients with resistant hypertension. The effects of BAT in patients with …

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Intraoperative monitoring of carotid endarterectomy by transcranial motor evoked potential: A multicenter study of 600 patients

Michael J. Malcharek, Sedat Ulkatan, V. Marinò, Martin Geyer et autres

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Barorezeptorstimulation als Therapie der refraktären Hypertonie und ihrer Endorganschäden

Joachim Beige, G. Hennig, Rolf Wachter

395 Valid PCR quantification of mRNA from 16 year old formalin-fixed, paraffin-embedded breast cancer tissue: a methodological study comparing manually trimmed sections and whole tissue sections

Trine Tramm, G. Hennig, Torsten Acht, Jan Alsner et autres

Quantitative determination of predictive cancer biomarkers in formalin-fixed, paraffin-embedded tissue using a new, fully automated method for RNA isolation

Berit Müller, Ralf Kronenwett, G. Hennig, Karsten E. Weber et autres

11032 Background: Personalized cancer therapy depends on the evaluation of tissue-based biomarkers in routine tumor samples. As many new biomarkers are measured on the mRNA level, standardized procedures for mRNA analysis in formalin-fixed, paraffin-embedded (FFPE) tissue are needed. In this study, we …

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Utility of a multigene prognostic algorithm in combination with TP53 expression for prediction of benefit from adjuvant taxane-containing chemotherapy in node-positive breast cancer patients

Ralf Kronenwett, Udo Stropp, Evangelos Briasoulis, Mathias Gehrmann et autres

593 Background: Recently, we have shown that the Siemens Prognostic Score (SPS) based on mRNA expression of nine informative genes predicted outcome in node-positive (N+) patients with breast cancer (SABCS 2008, abstract 6044). The aim of this retrospective biomarker study was to …

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Molecular breast cancer prognosis in node negative early breast cancer.

Marjanka K. Schmidt, Trine Tramm, Daniel Böhm, Marianne Kyndi et autres

Abstract Abstract #1071 Background: A number of molecular signatures have been published to aid breast cancer prognosis and therapy response prediction. However, most signatures rely on measurements of dozens of genes on an array platform. Here we report the identification and validation …

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Elevated mRNA expression of herstatin predicts poor outcome in patients with high-risk early breast cancer. A possible molecular predictor of treatment benefit in the context of a Hellenic cooperative oncology group trial.

C. Papadimitriou, KT Kalogeras, RM Wirtz, Evangelos Briasoulis et autres

Abstract Abstract #6066 Background: Herstatin is a naturally occurring product of the HER2 gene generated by alternative mRNA splicing. It functions as a secreted inhibitor that binds to the extracellular domains of EGFR and HER2, disrupting multiple receptor combinations in response to …

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