Ahmet Güçlü

When Meta is the Internet : a critical analysis of the colonialities of free basics and connectivity initiatives

Ahmet Güçlü

This thesis offers a critical analysis of the colonialities embedded in Free Basics (FBS) within Meta Connectivity (MC) initiatives by examining three interlinked processes: infrastructuralisation, platformisation and datafication. It traces Meta’s connectivity initiatives, Internet.org, Free Basics, and Discover by focusing on how …

ALCAPA syndrome, a rare cause of sudden cardiac death

Thijs Braber, Mohamed Mouden, Siert Knollema, Ahmet Güçlü

Fig. 1 a Computed tomography angiography showed an anomalous origin of the left coronary artery (LCA, red arrow) from the pulmonary artery (PA), b an ectatic and tortuous LCA (red arrow)

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Distinct Metabolomic Signatures in Preclinical and Obstructive Hypertrophic Cardiomyopathy

Maike Schuldt, Beau van Driel, Sıla Algül, Rahana Y. Parbhudayal et autres

Hypertrophic Cardiomyopathy (HCM) is a common inherited heart disease with poor risk prediction due to incomplete penetrance and a lack of clear genotype–phenotype correlations. Advanced imaging techniques have shown altered myocardial energetics already in preclinical gene variant carriers. To determine whether disturbed …

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Metabolomics in Severe Aortic Stenosis Reveals Intermediates of Nitric Oxide Synthesis as Most Distinctive Markers

Beau van Driel, Maike Schuldt, Sıla Algül, Evgeni Levin et autres

BACKGROUND: Calcific aortic valve disease (CAVD) is a rapidly growing global health problem with an estimated 12.6 million cases globally in 2017 and a 112% increase of deaths since 1990 due to aging and population growth. CAVD may develop into aortic stenosis …

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Myocardial adaptation after surgical therapy differs for aortic valve stenosis and hypertrophic obstructive cardiomyopathy

Rahana Y. Parbhudayal, Ahmet Güçlü, Alwin Zweerink, P. Stefan Biesbroek et autres

Surgical therapies in aortic valve stenosis (AVS) and hypertrophic obstructive cardiomyopathy (HOCM) aim to relief intraventricular pressure overload and improve clinical outcome. It is currently unknown to what extent myocardial adaptation concurs with restoration of intraventricular pressures, and whether this is similar …

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Disease Stage–Dependent Changes in Cardiac Contractile Performance and Oxygen Utilization Underlie Reduced Myocardial Efficiency in Human Inherited Hypertrophic Cardiomyopathy

Ahmet Güçlü, Paul Knaapen, Hendrik J. Harms, Rahana Y. Parbhudayal et autres

BACKGROUND: Reduced myocardial efficiency represents a target for therapy in hypertrophic cardiomyopathy although therapeutic benefit may depend on disease stage. Here, we determined disease stage-dependent changes in myocardial efficiency and effects of myectomy surgery. METHODS AND RESULTS: C]-acetate positron emission tomography and …

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Cardiac Myosin Binding Protein-C Autoantibodies Are Potential Early Indicators of Cardiac Dysfunction and Patient Outcome in Acute Coronary Syndrome

Thomas L. Lynch, Diederik W.D. Kuster, Beverly González, Neelam Balasubramanian et autres

The degradation and release of cardiac myosin binding protein-C (cMyBP-C) upon cardiac damage may stimulate an inflammatory response and autoantibody (AAb) production. We determined whether the presence of cMyBP-C-AAbs associated with adverse cardiac function in cardiovascular disease patients. Importantly, cMyBP-C-AAbs were significantly …

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Left ventricular outflow tract gradient is associated with reduced capillary density in hypertrophic cardiomyopathy irrespective of genotype

Ahmet Güçlü, Chris Happé, Seyma Nur Eren, H. Ibrahim Korkmaz et autres

BACKGROUND: Coronary microvascular dysfunction (CMD) is an important feature of hypertrophic cardiomyopathy (HCM), which contributes negatively to symptoms and long-term outcome. Previous in vivo imaging studies in HCM suggest that left ventricular outflow tract (LVOT) gradient and genetic status are important contributors …

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SEPTAL MYECTOMY DOES NOT IMPROVE SEPTAL MYOCARDIAL EFFICIENCY IN HYPERTROPHIC CARDIOMYOPATHY

Ahmet Güçlü, Paul Knaapen, Hendrik J. Harms, Patrick Klein et autres

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Myocardial efficiency is an important determinant of functional improvement after aortic valve replacement in aortic valve stenosis patients: a combined PET and CMR study

Ahmet Güçlü, Paul Knaapen, Hendrik J. Harms, Alexander B.A. Vonk et autres

AIMS: The pathophysiology underlying aortic valve stenosis (AVS)-induced cardiac dysfunction and reduced exercise capacity is unclear. We hypothesize that improvement of myocardial external efficiency (MEE)--the ratio between external work and myocardial oxygen consumption (MVO2)--underlies functional improvement of AVS patients after aortic valve …

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Sex-dependent pathophysiological mechanisms in hypertrophic cardiomyopathy: Implications for rhythm disorders

Louise L.A.M. Nijenkamp, Ahmet Güçlü, Yolande Appelman, Jolanda van der Velden et autres

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Sexual dimorphic response to exercise in hypertrophic cardiomyopathy-associated MYBPC3-targeted knock-in mice

Aref Najafi, Saskia Schlossarek, Elza D. van Deel, Nikki van den Heuvel et autres

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