Leonard Khiroug

Cognitive Neuroscience of Pain

Vahid Rakhshan, Donald B. Giddon, Milica Prostran, Leonard Khiroug et autres

Non peer reviewed

ir, us, rs, fi, gb (code pays fourni par la source)

Dissociation Between Neuronal and Astrocytic Calcium Activity in Response to Locomotion in Mice

Anna Fedotova, Alexey Brazhe, Maxim Doronin, Dmytro Toptunov et autres

Abstract Locomotion triggers a coordinated response of both neurons and astrocytes in the brain. Here we performed calcium (Ca2+) imaging of these two cell types in the somatosensory cortex in head-fixed mice moving on the airlifted platform. Ca2+ activity in astrocytes significantly …

ru, cn, es, gb, lt (code pays fourni par la source)

A call for better understanding of target engagement in Tau antibody development

Anton Bespalov, Jean‐Philippe Courade, Leonard Khiroug, Georg C. Terstappen et autres

us, fi, cn (code pays fourni par la source)

Coming full circle: In vivo Veritas, or expanding the neuroscience frontier

Leonard Khiroug, Alexei Verkhratsky

fi, es (code pays fourni par la source)

In vivo Two-Photon Imaging of Anesthesia-Specific Alterations in Microglial Surveillance and Photodamage-Directed Motility in Mouse Cortex

Wei‐Lun Sun, K. Suzuki, Dmytro Toptunov, Stoyan Stoyanov et autres

Two-photon imaging of fluorescently labelled microglia in vivo provides a direct approach to measure motility of microglial processes as a readout of microglial function that is crucial in the context of neurodegenerative diseases, as well as to understand the neuroinflammatory response to …

de, jp, fi (code pays fourni par la source)

Chemical and photonic interactions in vitro and in vivo between fluorescent tracer and nanoparticle-based scavenger for enhanced molecular imaging

Tina Gulin-Sarfraz, Evgeny Pryazhnikov, Jixi Zhang, Leonard Khiroug et autres

We hereby present a concept of scavenging excess imaging agent prior to a diagnostic imaging session, consequently allowing for enhanced contrast of signals originating from the tissue area of interest to the signals originating from systemic imaging agent residues. In our study, …

fi, no, cn (code pays fourni par la source)

SAR228810: an antibody for protofibrillar amyloid β peptide designed to reduce the risk of amyloid-related imaging abnormalities (ARIA)

Laurent Pradier, Véronique Blanchard-Brégeon, Andrees Bohme, Thomas Debeir et autres

BACKGROUND: Anti-amyloid β (Aβ) immunotherapy represents a major area of drug development for Alzheimer's disease (AD). However, Aβ peptide adopts multiple conformations and the pathological forms to be specifically targeted have not been identified. Aβ immunotherapy-related vasogenic edema has also been severely …

fr, us, jp (code pays fourni par la source)

Emerging Role of (Endo)Cannabinoids in Migraine

Pinja Leimuranta, Leonard Khiroug, Rashid Giniatullin

In this mini-review, we summarize recent discoveries and present new hypotheses on the role of cannabinoids in controlling trigeminal nociceptive system underlying migraine pain. Individual sections of this review cover key aspects of this topic, such as: (i) the current knowledge on …

fi, ru (code pays fourni par la source)

Longitudinal two-photon imaging in somatosensory cortex of behaving mice reveals dendritic spine formation enhancement by subchronic administration of low-dose ketamine

Evgeny Pryazhnikov, Ekaterina Mugantseva, Plínio Casarotto, Julia Kolikova et autres

Ketamine, a well-known anesthetic, has recently attracted renewed attention as a fast-acting antidepressant. A single dose of ketamine induces rapid synaptogenesis, which may underlie its antidepressant effect. To test whether repeated exposure to ketamine triggers sustained synaptogenesis, we administered a sub-anesthetic dose …

fi, us (code pays fourni par la source)

Integrin α4 Overexpression on Rat Mesenchymal Stem Cells Enhances Transmigration and Reduces Cerebral Embolism After Intracarotid Injection

Lili Cui, Franziska Nitzsche, Evgeny Pryazhnikov, Marina Tibeykina et autres

BACKGROUND AND PURPOSE: Very late antigen-4 (integrin α4β1)/vascular cell adhesion molecule-1 mediates leukocyte trafficking and transendothelial migration after stroke. Mesenchymal stem cells (MSCs) typically express integrin β1 but insufficient ITGA4 (integrin α4), which limits their homing after intravascular transplantation. We tested whether …

us, fi, de (code pays fourni par la source)

Implications of the N-terminal heterogeneity for the neuronal K-Cl cotransporter KCC2 function

Marika Markkanen, Anastasia Ludwig, Stanislav Khirug, Evgeny Pryazhnikov et autres

fi, us, fr (code pays fourni par la source)

Isoflurane produces antidepressant effects and induces TrkB signaling in rodents

Hanna Antila, Maria Ryazantseva, Dina Popova, Pia Sipilä et autres

A brief burst-suppressing isoflurane anesthesia has been shown to rapidly alleviate symptoms of depression in a subset of patients, but the neurobiological basis of these observations remains obscure. We show that a single isoflurane anesthesia produces antidepressant-like behavioural effects in the learned …

fi, fr, us (code pays fourni par la source)