Ekaterina Mugantseva

Low-Molecular Weight Protamine Overcomes Chondroitin Sulfate Inhibition of Neural Regeneration

Natalia Kulesskaya, Ekaterina Mugantseva, Rimante Minkeviciene, Natalia Acosta‐Baena et autres

Protamine is an arginine-rich peptide that replaces histones in the DNA-protein complex during spermatogenesis. Protamine is clinically used in cardiopulmonary bypass surgery to neutralize the effects of heparin that is required during the treatment. Here we demonstrate that protamine and its 14–22 …

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Analysis of the Effect of Neuroprotectors That Reduce the Level of Degeneration of Neurons in the Rat Hippocampus Caused by Administration of Beta-Amyloid Peptide Aβ25-35

Rita Ya. Gordon, E. G. Makarova, Ekaterina Mugantseva, S. S. Khutsyan et autres

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Heparin-Binding Growth-Associated Molecule (Pleiotrophin) Affects Sensory Signaling and Selected Motor Functions in Mouse Model of Anatomically Incomplete Cervical Spinal Cord Injury

Natalia Kulesskaya, Dmitry A. Molotkov, Sonny Sliepen, Ekaterina Mugantseva et autres

Heparin-binding growth-associated molecule (pleiotrophin) is a neurite outgrowth-promoting secretory protein that lines developing fiber tracts in juvenile CNS (central nervous system). Previously, we have shown that heparin-binding growth-associated molecule (HB-GAM) reverses the CSPG (chondroitin sulfate proteoglycan) inhibition on neurite outgrowth in the …

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Voluntary Adolescent-Onset Alcohol Drinking Fails to Influence Alcohol Consumption or Anxiety-Like Behaviour in Adulthood in Female Alcohol-Preferring Rats

Ekaterina Mugantseva, Petri Hyytiä, Antti Latvala

AIMS: Alcohol exposure during adolescence is associated with both increased risk for alcohol use disorders and anxiety in adulthood. Our present experiments examined this association using alcohol-preferring AA (Alko Alcohol) rats selected for high voluntary alcohol drinking. METHODS: Two groups of female …

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Investigation of the action of neuroprotectors that reduce the level of degeneration of neurons in the rat hippocampus, caused by the administration of beta-amyloid peptide Aβ25-35

Rita Ya. Gordon, E. G. Makarova, Ekaterina Mugantseva, S. S. Khutsyan et autres

Longitudinal two-photon imaging in somatosensory cortex of behaving mice reveals dendritic spine formation enhancement by subchronic administration of low-dose ketamine

Evgeny Pryazhnikov, Ekaterina Mugantseva, Plinio Cabrera Casarotto, Julia Kolikova et autres

Ketamine, a well-known anesthetic, has recently attracted renewed attention as a fast-acting antidepressant. A single dose of ketamine induces rapid synaptogenesis, which may underlie its antidepressant effect. To test whether repeated exposure to ketamine triggers sustained synaptogenesis, we administered a sub-anesthetic dose …

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Microscopic Study of Nervous System Plasticity: Interactions of Sympathetic Nerves with Neurons of Intraocular Hippocampal Transplants

З. Н. Журавлева, Ekaterina Mugantseva, Г. И. Журавлев

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Intrahippocampal Pathways Involved in Learning/Memory Mechanisms are Affected by Intracerebral Infusions of Amyloid-β25-35 Peptide and Hydrated Fullerene C60 in Rats

Rita Ya. Gordon, I. Ya. Podolski, E. G. Makarova, А. Д. Деев et autres

Primary memory impairments associated with increased level of amyloid-β (Aβ) in the brain have been shown to be linked, partially, with early pathological changes in the entorhinal cortex (EC) which spread on the whole limbic system. While the hippocampus is known to …

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HB-GAM (pleiotrophin) reverses inhibition of neural regeneration by the CNS extracellular matrix

Mikhail Paveliev, Keith K. Fenrich, Mikhail Kislin, Juha Kuja‐Panula et autres

Chondroitin sulfate (CS) glycosaminoglycans inhibit regeneration in the adult central nervous system (CNS). We report here that HB-GAM (heparin-binding growth-associated molecule; also known as pleiotrophin), a CS-binding protein expressed at high levels in the developing CNS, reverses the role of the CS …

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Amyloid Plaques Show Binding Capacity of Exogenous Injected Amyloid-β

Irina Gureviciene, Kestutis Gurevicius, Ekaterina Mugantseva, Mikhail Kislin et autres

Amyloid plaques, although inducing damage to the immediately surrounding neuropil, have been proposed to provide a relatively innocuous way to deposit toxic soluble amyloid-β (Aβ) species. Here we address this hypothesis by exploring spread and absorption of fluorescent Aβ to pre-existing amyloid …

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Transsynaptic Coordination of the Formation of Morphofunctional Contacts between the Brain and the Neurotransplant: an Ulrastructural Study

З. Н. Журавлева, Г. И. Журавлев, Ekaterina Mugantseva

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Flat-floored Air-lifted Platform: A New Method for Combining Behavior with Microscopy or Electrophysiology on Awake Freely Moving Rodents

Mikhail Kislin, Ekaterina Mugantseva, Dmitry A. Molotkov, Natalia Kulesskaya et autres

It is widely acknowledged that the use of general anesthetics can undermine the relevance of electrophysiological or microscopical data obtained from a living animal's brain. Moreover, the lengthy recovery from anesthesia limits the frequency of repeated recording/imaging episodes in longitudinal studies. Hence, …

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