Shallu Tomer

Transient rapamycin treatment avoids unwanted host immune responses toward AAV-delivered anti-HIV antibodies

Sebastian P. Fuchs, P.G. Mondragon, Rachel Zabizhin, Shallu Tomer et autres

Long-term delivery of broadly neutralizing antibodies (bnAbs) using adeno-associated virus (AAV) vector is a promising approach for both the prevention and treatment of HIV infection. However, host anti-drug antibody (ADA) responses severely limit the continuous delivery of these anti-HIV bnAbs and have …

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Structural Evaluations of a Selective Human STINGA230 Agonist and Its Use in Macrophage Immunotherapies

Zhichao Tang, Junxing Zhao, Ying Li, Shallu Tomer et autres

Previously we identified a non-nucleotide agonist BDW568 that selectively activates the human STING A230 allele. Here, we further characterized the mechanism of BDW568 and highlighted its potential use for selectively controlling the activation of engineered macrophages that constitutively express STING A230 as …

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Structural and Biological Evaluations of a Non-Nucleoside STING Agonist Specific for Human STING A230 Variants

Zhichao Tang, Junxing Zhao, Ying Li, Shallu Tomer et autres

ABSTRACT Previously we identified a non-nucleotide tricyclic agonist BDW568 that activates human STING (stimulator of interferon genes) gene variant containing A230 in a human monocyte cell line (THP-1). STING A230 alleles, including HAQ and AQ, are less common STING variants in human …

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RWD85 Association between Relative Risk of Dementia and Baseline Visual Impairment Along with Other Confounding Features

V. Verma, S. K. Bhargava, Aditya Gaur, Shashi Khan et autres

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RWD82 To Study the Impact of Long COVID-19 in the US - A 9-Month Retrospective Study

Atanu Roy, Ayushi Gupta, Ashutosh Nayyar, Shashank Bhargava et autres

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Delineate the effects of cannabidiol on type 1 IFN mediated inflammation during HIV infection

Shallu Tomer, Wenli Mu, Hwee L. Ng, Li Wang et autres

Abstract Methods THP-1 and HMC3 cells were exposed to CBD/vehicle with and without stimulation with 2’3’-cGAMP (cGAMP), LPS, or PMA/ionomycin. qPCR was carried out to investigate the expression of interferon stimulatory genes (ISGs). RNA-Seq was performed to investigate gene expression in cGAMP-stimulated …

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Neutrophil dysfunction predicts 90‐day survival in patients with acute on chronic liver failure: A longitudinal case–control study

Kunaal Makkar, Shallu Tomer, Nipun Verma, Sahaj Rathi et autres

Abstract Background and Aim Innate immune disarray is a key component in the development and progression of acute on chronic liver failure (ACLF) and predisposition to infections. We evaluated the neutrophil dysfunction and its impact on outcomes in patients with ACLF. Methods …

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A juggernaut of innate & adaptive immune cells in chronic hepatitis C

Shallu Tomer

Hepatitis C virus (HCV) is a small positive-sense, single-stranded RNA virus, the causal organism for chronic hepatitis. Chronic hepatitis leads to inflammation of liver, causing cirrhosis, fibrosis and steatosis, which may ultimately lead to liver cancer in a few cases. Innate and …

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SAT-016 ENDOTHELIAL DYSFUNCTION REVERSES WITH RENAL FUNCTION RECOVERY IN PATIENTS WITH DIALYSIS REQUIRING COMMUNITY-ACQUIRED AKI WITH SIRS

Neeraj Inamdar, Arun Prabhahar, Shallu Tomer, Akash Bansal et autres

Acute Kidney Injury (AKI) causes a significant burden on healthcare. Impaired endothelial function plays an essential role in the pathogenesis of AKI, the progression of AKI to Chronic kidney disease (CKD) and future atherosclerotic events. Patients with AKI have demonstrable endothelial dysfunction. …

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Reversal of endothelial dysfunction post-immunosuppressive therapy in adult-onset podocytopathy and primary membranous nephropathy

Neeraj Inamdar, Shallu Tomer, Sunil Kalmath, Akash Bansal et autres

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FP321ENDOTHELIAL DYSFUNCTION IN COMMUNITY ACUTE KIDNEY INJURY REQUIRING SHORT-TERM DIALYSIS

Arun Prabhahar, Shallu Tomer, Akash Bansal, Sunil Kumar Arora et autres

INTRODUCTION: Endothelial dysfunction (ED) represents a stage of reversible atherosclerosis. The literature on ED in acute kidney injury (AKI) patients is scanty. So, the present study was undertaken to study the ED in patients with community-acquired AKI-stage 3 who required dialysis of …

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Change in serum levels of inflammatory markers reflects response of percutaneous catheter drainage in symptomatic fluid collections in patients with acute pancreatitis

Bipadabhanjan Mallick, Shallu Tomer, Sunil Kumar Arora, Anupam Lal et autres

Background Percutaneous catheter drainage (PCD) is used as the first step in the management of symptomatic fluid collections in patients with acute pancreatitis (AP). There are limited data on the effect of PCD on inflammatory markers. Aim To study the effects of …

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