Alain Friboulet

Role of κ→λ light-chain constant-domain switch in the structure and functionality of A17 reactibody

Natalia A. Ponomarenko, S.D. Chatziefthimiou, Inna N. Kurkova, Yuliana A. Mokrushina et autres

The engineering of catalytic function in antibodies requires precise information on their structure. Here, results are presented that show how the antibody domain structure affects its functionality. The previously designed organophosphate-metabolizing reactibody A17 has been re-engineered by replacing its constant κ light …

ru, de, fr (code pays fourni par la source)

Liposome‐encapsulated peptides protect against experimental allergic encephalitis

Alexey A. Belogurov, Alexey V. Stepanov, Ivan V. Smirnov, Dobroslav Melamed et autres

Multiple sclerosis (MS) is a severe inflammatory and neurodegenerative disease with an autoimmune background. Despite the variety of therapeutics available against MS, the development of novel approaches to its treatment is of high importance in modern pharmaceutics. In this study, experimental autoimmune …

ru, il, gb, fr, Maroc (code pays fourni par la source)

Routes to Covalent Catalysis by Reactive Selection for Nascent Protein Nucleophiles

Andrey V. Reshetnyak, Maria Francesca Armentano, Natalia A. Ponomarenko, Domenica Vizzuso et autres

Reactivity-based selection strategies have been used to enrich combinatorial libraries for encoded biocatalysts having revised substrate specificity or altered catalytic activity. This approach can also assist in artificial evolution of enzyme catalysis from protein templates without bias for predefined catalytic sites. The …

ru, us (code pays fourni par la source)

Substrate inhibition or activation kinetics of the β-galactosidase from the extreme thermoacidophile archaebacterium Caldariella acidophila

Sylviane Pulvin, Alain Friboulet, Daniel Thomas

fr (code pays fourni par la source)