Wing Lok Au

Neuropsychiatric outcomes after deep brain stimulation for Parkinson's disease – Real-world data from a national movement disorders unit

Lip Jie Saw, Lai Gwen Chan, Wei Li, Hwee Lan Ng et autres

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Longitudinal MRI study of hippocampal subfields Morphometry in early Parkinson's disease

Tingyu Wu, Samuel Yong-Ern Ng, Thomas Wei Jun Teo, Xinyi Choi et autres

BACKGROUND: Parkinson's Disease (PD) is a neurodegenerative disorder characterised by motor and non-motor symptoms. Cognitive impairment is a prominent non-motor feature. OBJECTIVE: This study investigated hippocampal subfield shape deformation and atrophy in early-stage PD using spherical harmonic-based shape analysis. METHODS: Our cohort …

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Transfer Learning from Pre‐trained 3D Models for Enhanced Parkinson's Disease Detection

Tanvi Verma, Jia Huang, Yuting Song, Mingrui Tan et autres

BACKGROUND: Deep learning models for Parkinson's disease (PD) diagnosis through Magnetic Resonance Imaging (MRI) face significant challenges due to limited labeled datasets. While deep learning approaches show promise, the scarcity of large-scale annotated MRI datasets for PD detection constrains model performance. Transfer …

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Brain‐FM: A Multimodal Foundation Model for Visual Question Answering in Brain Health Diagnostics

Somayeh Ebrahimkhani, Guimeng Liu, Tianze Yu, Xuling Lin et autres

BACKGROUND: Despite advancements in AI for diagnosing neurodegenerative diseases (NDs) like Alzheimer's (AD), existing models are task-specific and lack diagnostic reasoning, limiting their ability to interpret complex clinical and imaging data. Leveraging recent progress in multimodal foundation models (FMs) for healthcare, we …

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Transforming Assessment of Behavioral Impairment: The Role of Facial AI Technologies

Yuting Song, Bingjie Wu, Menghan Zhou, Xingyao Wang et autres

BACKGROUND: Early detection of behavioral impairment is vital for timely intervention and improved patient outcomes. However, traditional assessment tools are limited by practice effects and lack of trained staff in busy clinics. Impaired behavioral symptoms are increasingly shown to be associated with …

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Freezing of Gait Detection and Prediction Based on a Dilated Temporal Encoder Approach

Jialiang Li, Arthur E. Tay, Wing Lok Au, Dawn M. L. Tan et autres

Freezing of Gait (FoG) is a debilitating symptom of Parkinson's Disease, severely impairing mobility and increasing the risk of falls. We propose a novel framework for FoG detection and prediction using wearable inertial measurement unit (IMU) sensors, collected from 40 Parkinson's patients. …

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LINC00323 variant is associated with increased risk of essential tremor

Brendan Jen‐Wei Tan, Ebonne Ng, Qiao Yang Sun, Ling Ling Chan et autres

Essential tremor (ET) is a common adult movement disorder, with accumulating evidence suggesting that genetic factors primarily account for ET risk. However, replication studies on the genetic variants have yielded inconsistent results. In our case-control study, we show that the LINC00323 variant, …

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Carriers of Parkinson’s disease-linked SNCA Rep1 variant have greater non-motor decline: a 4 year follow up study

Aarthi Santhanakrishnan, Yi Jayne Tan, Seyed Ehsan Saffari, Yi Zhao et autres

= 0.001), highlighting the utility of Rep1 polymorphism in stratifying patients at risk of non-motor symptom decline.

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Long-term outcomes of subthalamic nucleus deep brain stimulation for Parkinson’s disease in Singapore

Yi Cai, Yilong Zheng, Wei Li, Seyed Ehsan Saffari et autres

Introduction: Subthalamic nucleus deep brain stimulation (STN-DBS) is a proven treatment modality for Parkinson’s disease (PD), reducing dyskinesia and time spent in the “OFF” state. This study evaluates the long-term outcomes of STN-DBS in PD patients up to 10 years post-surgery in …

sg, us (code pays fourni par la source)

Long-term outcomes of subthalamic nucleus deep brain stimulation for Parkinson’s disease in Singapore

Yi Cai, Yilong Zheng, Wei Li, Seyed Ehsan Saffari et autres

Introduction: Subthalamic nucleus deep brain stimulation (STN-DBS) is a proven treatment modality for Parkinson’s disease (PD), reducing dyskinesia and time spent in the “OFF” state. This study evaluates the long-term outcomes of STN-DBS in PD patients up to 10 years post-surgery in …

sg, us (code pays fourni par la source)

Outcomes after deep brain stimulation for elderly versus non-elderly patients with Parkinson’s disease

Yilong Zheng, Wei Li, Samantha Ya Lyn Ang, Hwee Lan Ng et autres

INTRODUCTION: The decision to offer deep brain stimulation (DBS) to elderly patients with Parkinson's disease (PD) presents challenges due to higher perceived risks and uncertain long-term benefits. Here, we aimed to compare the outcomes after DBS for elderly versus non-elderly patients with …

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iTRAQ‐based proteomic analysis reveals myeloperoxidase (MPO) as a diagnostic and prognostic biomarker of cognitive decline in Parkinson’s disease

Yi Jayne Tan, Ebonne Ng, Samuel YE Ng, Nicole SY Chia et autres

Abstract Background Parkinson’s disease (PD) is the second most common progressive neurodegenerative disorder and is characterized by loss of dopaminergic neurons, leading to debilitating motor, cognitive, and behavioral symptoms. At present, there are no biological markers for antemortem PD diagnosis. Methods To …

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