Accès ouvert
2026
article
OpenAlex
Raziyeh Mohammadi, Samuel YE Ng, Jayne Yi Tan, Adeline S. L. Ng et autres
Cognitive decline is a major non-motor complication in early Parkinson's disease (PD), but predicting its progression remains challenging. Using data from 193 participants in the Early Parkinson's Disease Longitudinal Singapore (PALS) cohort, we evaluated whether repeated blood biomarker measurements (baseline, year 3, …
sg, us, gb
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Accès ouvert
2023
article
OpenAlex
Yi Jayne Tan, Ebonne Ng, Samuel YE Ng, Nicole SY Chia et autres
Abstract Background Parkinson’s disease (PD) is the second most common progressive neurodegenerative disorder and is characterized by loss of dopaminergic neurons, leading to debilitating motor, cognitive, and behavioral symptoms. At present, there are no biological markers for antemortem PD diagnosis. Methods To …
sg
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Alisa Cui Wen Yong, Yi Jayne Tan, Ebonne Ng, Zhonghao Lu et autres
Abstract Background Plasma neurofilament light chain (NfL) levels reflect large calibre myelinated axonal loss; and has been proposed as a blood‐based biomarker for neurodegeneration in dementia and parkinsonian disorders. Recent studies have suggested an association between increased plasma NfL levels and worse …
sg
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Alisa Cui Wen Yong, Yi Jayne Tan, Yi Zhao, Zhonghao Lu et autres
Rep1 allele length influences overall non-motor symptom burden and depression in early PD patients. Further functional studies to evaluate the role of Rep1 in non-dopaminergic systems may unravel new therapeutic targets for non-motor symptoms in PD.
sg
(code pays fourni par la source)
Accès ouvert
2017
article
OpenAlex
Zheyu Xu, Jinglin Zhang, Samuel YE Ng, Josiah YH Chai et autres
The initial presentation of cerebellar ataxia remains a diagnostic challenge due to its multiple etiologies, one of which is paraneoplastic cerebellar degeneration (PCD), a rare neurological disease.Although paraneoplastic antibody testing may be helpful, seronegative PCD may account for up to 50% of …
sg, cn
(code pays fourni par la source)