Vance G. Fowler

Distinct molecular epidemiology and outcomes of carbapenem-resistant gram-negative infections in Lebanon: insights from the MDRO network

Jean-Francois Jabbour, Hind Kadri, ELIO JABRA, Joya-Rita Hindy et autres

This study provides the first prospective, genomically validated dataset integrated into the global MultiDrug-Resistant Organism (MDRO) Network from the Middle East and North Africa region. To address the substantial gap in antimicrobial resistance (AMR) data, the American University of Beirut Medical Center …

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The impact of follow-up blood cultures on mortality and management in patients with gram-negative bloodstream infections: a validation cohort study

Joshua T. Thaden, Felicia Ruffin, Lawrence P. Park, Parisa Farahani et autres

BACKGROUND: The practice of obtaining follow-up blood cultures (FUBCs) in patients with gram-negative bloodstream infections (GN-BSI) remains controversial. The current study had two goals: (1) to internally validate our earlier findings of decreased mortality in patients with FUBCs and increased mortality in …

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Additional file 1 of The impact of follow-up blood cultures on mortality and management in patients with gram-negative bloodstream infections: a validation cohort study

Joshua T. Thaden, Felicia Ruffin, Lawrence P. Park, Parisa Farahani et autres

Supplementary Material 1

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Additional file 1 of The impact of follow-up blood cultures on mortality and management in patients with gram-negative bloodstream infections: a validation cohort study

Joshua T. Thaden, Felicia Ruffin, Lawrence P. Park, Parisa Farahani et autres

Supplementary Material 1

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Fast Antimicrobial Susceptibility Testing for Gram-Negative Bacteremia

Ritu Banerjee, Lauren Komarow, Yixuan Li, Donald Mau et autres

Importance: Novel blood culture diagnostics provide rapid antimicrobial susceptibility testing (AST) results for bacteria causing bloodstream infections (BSIs) but have unclear clinical impact. Objective: To evaluate clinical outcomes of blood culture testing using a rapid AST method compared with standard AST in …

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Study protocol for a multicenter, multinational prospective randomized controlled trial comparing outcomes in subjects with Gram-negative bacteremia who have blood culture evaluation using Fast Antibiotic Susceptibility Testing vs. standard of care testing: the FAST trial

Ritu Banerjee, Lauren Komarow, Yixuan Li, Qiuwen Wu et autres

BACKGROUND: Novel, rapid blood culture diagnostics can provide faster antibiotic susceptibility results (AST) compared to standard methods but their impact on clinical outcomes is unclear and not assessed in many prospective clinical trials. METHODS: This study is a two-arm, multicenter, multinational, prospective …

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A network analysis of carbapenem-resistant Klebsiella pneumoniae among healthcare facilities

Vance G. Fowler, Eric Cober, Yohei Doi, Andrea M. Hujer et autres

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A network analysis of carbapenem-resistant Klebsiella pneumoniae among healthcare facilities

Courtney Luterbach, Dana K. Pasquale, Heather Henderson, Eric Cober et autres

With limited treatments for carbapenem-resistant Klebsiella pneumoniae (CRKp), curtailing transmission is critical. We applied a network analysis using epidemiological admission data and bacterial genetics to characterize CRKp spread among patients in 16 acute care hospitals linked to 217 other healthcare facilities in …

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Management of Staphylococcus aureus Bacteremia

Steven Y. C. Tong, Vance G. Fowler, Lesley A. Skalla, Thomas L Holland

Importance: Staphylococcus aureus, a gram-positive bacterium, is the leading cause of death from bacteremia worldwide, with a case fatality rate of 15% to 30% and an estimated 300 000 deaths per year. Observations: Staphylococcus aureus bacteremia causes metastatic infection in more than …

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Bioresorbable Suture Anchor Clips for Soft Tissue Wound Repair

Alexander J. Bahnick, David S. Ruppert, Gabriella A. Krisanic, Jeffrey I. Everitt et autres

Mesh suture is an emerging technology for closing high-tension soft tissue wounds. However, bulky mesh surgical knots can irritate surrounding tissue and harbor bacteria, leading to an increased risk of infection and palpability. Thus, a degradable knotless anchoring system is needed to …

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Treatment Approaches for Carbapenem-Resistant Acinetobacter baumannii Infections

Alina Iovleva, Vance G. Fowler, Yohei Doi

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ARGONAUT-IV: susceptibility of carbapenemase-producing Klebsiella pneumoniae to the oral bicyclic boronate β-lactamase inhibitor ledaborbactam combined with ceftibuten

Michael R. Jacobs, Caryn E. Good, Ayman M. Abdelhamed, Andrew R Mack et autres

ABSTRACT Ledaborbactam (formerly VNRX-5236), a bicyclic boronate β-lactamase inhibitor with activity against class A, C, and D β-lactamases, is under development as an orally bioavailable etzadroxil prodrug (VNRX-7145) in combination with ceftibuten for the treatment of urinary tract infections. At ceftibuten breakpoints …

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