Dana K. Pasquale

Economic Outcomes of Dalbavancin versus Standard Therapy in Staphylococcus aureus Bacteremia in the DOTS Randomized Clinical Trial

Shelby D. Reed, Yanhong Li, Nicholas Turner, Dana K. Pasquale et autres

OBJECTIVE: The DOTS trial demonstrated similar clinical outcomes among 200 adults with complicated Staphylococcus aureus bacteremia (SAB) randomized to two doses of dalbavancin or standard-therapy antibiotics after initial clearance. We aimed to determine whether the higher cost of dalbavancin is offset through …

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A network analysis of carbapenem-resistant Klebsiella pneumoniae among healthcare facilities

Vance G. Fowler, Eric Cober, Yohei Doi, Andrea M. Hujer et autres

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A network analysis of carbapenem-resistant Klebsiella pneumoniae among healthcare facilities

Courtney Luterbach, Dana K. Pasquale, Heather Henderson, Eric Cober et autres

With limited treatments for carbapenem-resistant Klebsiella pneumoniae (CRKp), curtailing transmission is critical. We applied a network analysis using epidemiological admission data and bacterial genetics to characterize CRKp spread among patients in 16 acute care hospitals linked to 217 other healthcare facilities in …

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Identifying outbreak risk factors through case-controls comparisons

Nina H. Fefferman, Michael J. Blum, Lydia Bourouiba, Nathaniel L. Gibson et autres

Outbreaks are typically investigated using approaches that aim to identify place- and context-dependent causative factors. As the focus is on understanding the basis of a specific outbreak, the resulting narratives are rarely suitable for forecasting risk or developing generalizable predictive and preventative …

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Considerations for Social Networks and Health Data Sharing: An Overview

Dana K. Pasquale, Tom Wolff, Gabriel Varela, Peter J. Mucha et autres

The use of network analysis as a tool has increased exponentially as more clinical researchers see the benefits of network data for modeling of infectious disease transmission or translational activities in a variety of areas, including patient-caregiving teams, provider networks, patient-support networks, …

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ideanet: Integrating Data Exchange and Analysis for Networks ('ideanet')

Tom Wolff, Jonathan H. Morgan, Gabriel Varela, Kieran Lele et autres

A suite of convenient tools for social network analysis geared toward students, entry-level users, and non-expert practitioners. ‘ideanet’ features unique functions for the processing and measurement of sociocentric and egocentric network data. These functions automatically generate node- and system-level measures commonly used …

The Gaps That Remain: A Commentary on the 2024 JPHMP Article “Late Identification of Perinatal Transmission of HIV in an Infant at High-Risk”

Dana K. Pasquale, Emily D Niehaus, Chris Beyrer

Prevention of mother-to-child transmission (PMTCT) of HIV has been a key target for reducing the global burden of HIV for decades. The World Health Organization’s first set of PMTCT guidelines was produced in 2000.1 Then-President George W. Bush set prevention of transmission …

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Homophily and social mixing in a small community: Implications for infectious disease transmission

Dana K. Pasquale, Whitney Welsh, Keisha L. Bentley‐Edwards, Andrew Olson et autres

Community mixing patterns by sociodemographic traits can inform the risk of epidemic spread among groups, and the balance of in- and out-group mixing affects epidemic potential. Understanding mixing patterns can provide insight about potential transmission pathways throughout a community. We used a …

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A New Paradigm for Pandemic Preparedness

Nina H. Fefferman, John S. McAlister, Belinda S. Akpa, Kelechi Akwataghibe et autres

Purpose of Review: Preparing for pandemics requires a degree of interdisciplinary work that is challenging under the current paradigm. This review summarizes the challenges faced by the field of pandemic science and proposes how to address them. Recent Findings: The structure of …

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The Case for Controls: Identifying outbreak risk factors through case-control comparisons

Nina H. Fefferman, Michael J. Blum, Lydia Bourouiba, Nathaniel L. Gibson et autres

Investigations of infectious disease outbreaks often focus on identifying place- and context-dependent factors responsible for emergence and spread, resulting in phenomenological narratives ill-suited to developing generalizable predictive and preventive measures. We contend that case-control hypothesis testing is a more powerful framework for …

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Scalable Strategies to Increase Efficiency and Augment Public Health Activities During Epidemic Peaks

Dana K. Pasquale, Whitney Welsh, Andrew Olson, Mark Yacoub et autres

OBJECTIVE: Scalable strategies to reduce the time burden and increase contact tracing efficiency are crucial during early waves and peaks of infectious transmission. DESIGN: We enrolled a cohort of SARS-CoV-2-positive seed cases into a peer recruitment study testing social network methodology and …

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A method for intelligent allocation of diagnostic testing by leveraging data from commercial wearable devices: a case study on COVID-19

Md Mobashir Hasan Shandhi, Peter Cho, Ali R. Roghanizad, Karnika Singh et autres

Mass surveillance testing can help control outbreaks of infectious diseases such as COVID-19. However, diagnostic test shortages are prevalent globally and continue to occur in the US with the onset of new COVID-19 variants and emerging diseases like monkeypox, demonstrating an unprecedented …

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