I. Grant McQuaker

Presence of donor-encoded centromeric KIR B content increases the risk of infectious mortality in recipients of myeloablative, T-cell deplete, HLA-matched HCT to treat AML

Will P. Bultitude, Jennifer Schellekens, Richard Szydlo, Chloe Anthias et autres

gb, us, mx (code pays fourni par la source)

Role of HLA-B exon 1 in graft-versus-host disease after unrelated haemopoietic cell transplantation: a retrospective cohort study

Effie Wang Petersdorf, Mary N Carrington, Colm Ó’hUigín, Mats Bengtsson et autres

us, se, au, fr, gb, jp, nl, ch (code pays fourni par la source)

A reply to Hurley et al. regarding Recipients Receiving Better HLA-Matched Hematopoietic Cell Transplantation Grafts, Uncovered by a Novel HLA Typing Method, Have Superior Survival: A Retrospective Study

Neema P. Mayor, James D. Hayhurst, Thomas R. Turner, Richard Szydlo et autres

The publication of novel data that challenges current practice initiates important discussions, and we welcome the opportunity to respond to comments received on our article. The central dogma of HLA antigen recognition domain (ARD) matching has been largely brought about by limitations …

gb, us (code pays fourni par la source)

Recipients Receiving Better HLA-Matched Hematopoietic Cell Transplantation Grafts, Uncovered by a Novel HLA Typing Method, Have Superior Survival: A Retrospective Study

Neema P. Mayor, James D. Hayhurst, Thomas R. Turner, Richard Szydlo et autres

HLA matching at an allelic-level resolution for volunteer unrelated donor (VUD) hematopoietic cell transplantation (HCT) results in improved survival and fewer post-transplant complications. Limitations in typing technologies used for the hyperpolymorphic HLA genes have meant that variations outside of the antigen recognition …

gb, us (code pays fourni par la source)

Haemopoietic Stem Cell Transplantation

I. Grant McQuaker

The field of stem cell transplantation continues to develop rapidly, particularly in the use of alternative donors. Cord transplantation continues to evolve and is now established, though not yet optimized in adult practice. There is new interest in the use of haploidentical …

gb, ie (code pays fourni par la source)

The clinical features and outcome of 2009 H1N1 influenza infection in allo-SCT patients: a British Society of Blood and Marrow Transplantation study

Rachel Elizabeth Protheroe, Keiren Kirkland, Rachel M. Pearce, K Kaminaris et autres

gb (code pays fourni par la source)

Haemopoietic Stem Cell Transplantation

I. Grant McQuaker

This chapter contains sections titled: Introduction Principles of HSCTs The donor Conclusion Key Points Further reading

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TNF Polymorphisms Independently Predict Outcome in Patients with B-Cell Non-Hodgkin’s Lymphoma

NF Osman, Tessa L. Holyoake, Ashraf A Zeineldin, Amal Elkordy et autres

Tumour Necrosis Factor α (TNFα) and Lymphotoxin α (LTα) have been implicated in the pathogenesis of lymphoproliferative disorders. Patients with B-cell non-Hodgkin's lymphoma (NHL) often have high serum levels of TNF which may be associated with a poor outcome. TNFα and LTα …

gb, Égypte (code pays fourni par la source)

Complete molecular responses are achieved after reduced intensity stem cell transplantation and donor lymphocyte infusion in chronic myeloid leukemia

Nicholas B. Heaney, Mhairi Copland, Karen G. Stewart, Judith L. Godden et autres

Patients with newly diagnosed chronic phase chronic myeloid leukemia were treated with imatinib mesylate (IM) for 6 to 12 months to establish disease control, before reduced intensity stem cell transplantation (RISCT). Escalating doses of donor lymphocyte infusions were given from 6 months …

gb (code pays fourni par la source)

Ideal body weight correlates better with engraftment after PBSC autograft than actual body weight, but is under-estimated in myeloma patients possibly due to disease-related height loss

Peter MacLean, Anne N. Parker, I. Grant McQuaker, Andrew David Clark et autres

gb (code pays fourni par la source)

Oral sodium clodronate induced osteonecrosis of the jaw in a patient with myeloma

Amir H Montazeri, J G Erskine, I. Grant McQuaker

Bisphosphonate therapy has been shown to significantly reduce the incidence of skeletal complications in patients with myeloma. Several recent reports have described osteonecrosis of the jaw (ONJ) associated with bisphosphonates. These reports mainly demonstrate an association between ONJ and potent i.v. bisphosphonates. …

gb (code pays fourni par la source)

Fatal peripheral neuropathy following FLA chemotherapy

Wendy Osborne, Tessa L. Holyoake, I. Grant McQuaker, Anne N. Parker

We discuss a case with significant progressive peripheral neurological deterioration following administration of both fludarabine and cytarabine as part of the FLA (fludarabine and cytarabine) regime. Of particular interest is that toxicity only occurred during the second course of FLA and sixth …

gb (code pays fourni par la source)