José Rafael Cabrera

A paired trial comparing mononuclear cell collection in two machines for further inactivation through an inline or offline extracorporeal photopheresis procedure

José‐Luis Bueno, Rosalía Alonso, Clara Gonzalez‐Santillana, Daniel E. Naya et autres

BACKGROUND Extracorporeal photopheresis (ECP) is an effective treatment. However, protocols differ widely, and some questions, such as the number of cells to be collected or the number of ECP treatment days per treatment cycle, are still unsolved. The aim of this study …

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Use of defibrotide to treat adult patients with transplant-associated thrombotic microangiopathy

María Esther Martínez-Muñoz, Rafael Forés, Ana Rodríguez‐Villa Lario, G. Bautista et autres

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Growth differentiation factor 11 ( GDF 11) – a promising anti‐ageing factor – is highly concentrated in platelets

José Luis Bueno, M. Ynigo, C. De Miguel, Rosa M. Gonzalo‐Daganzo et autres

Recent research suggests that growth differentiation factor 11 (GDF11) could reverse age-related diseases and that its blood concentration decreases with age. This poses plasma from young donors as a therapeutic GDF11 source to treat age-related diseases. In addition, the tissue source of …

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Severe infections after single umbilical cord blood transplantation in adults with or without the co‐infusion of CD 34+cells from a third‐party donor: results of a multicenter study from the Grupo Español de Trasplante Hematopoyético ( GETH )

Rodrigo Martino, G. Bautista, Rocío Parody, Irene García et autres

BACKGROUND: Umbilical cord blood transplantation (CBT) is an established alternative source of stem cells in the setting of unrelated transplantation. When compared with other sources, single-unit CBT (sCBT) is associated with a delayed hematologic recovery, which may lead to a higher infection-related …

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Fungal and viral infections after allogeneic hematopoietic transplantation from unrelated donors in adults: improving outcomes over time

Rocío Parody, Rodrigo Martino, Rafael de la Cámara, Ana Garcia Noblejas et autres

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Paroxysmal nocturnal hemoglobinuria: a single S panish center's experience over the last 40 yr

Cristina Muñoz‐Linares, Emilio Díaz Ojeda, Rafael Forés, Miguel Pastrana et autres

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal disease. To date, many reviews and series have been described. We report the experience of our center by presenting a review of 56 PNH patient cases with an average age at diagnosis of 38 …

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HLA-partially matched cellular therapy (stem-cell microtransplantation) for acute myeloid leukaemia: description of four cases

Rafael Forés, Nieves Dorado, Carlos Vilches, Carmen Regidor et autres

Donor leucocyte infusions (DLI) after conventional chemotherapy have been proposed as a treatment for acute myeloid leukaemia (AML). This procedure has been successfully employed in AML elderly patients (Guo et al, 2011; Cignetti et al, 2013), low and intermediate-risk AML as post-remission …

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Paroxysmal Nocturnal Hemoglobinuria and Cancer: High Incidence Of Cancer In a Large Series Of PNH Patients In a Single Center

Cristina Muñoz‐Linares, Emilio Díaz Ojeda, Rafael Forés, Martín Cabero et autres

Abstract Since 1964, a total of 56 patients with Paroxysmal Nocturnal Hemoglobinuria clone (PNH) were evaluated in our Hematology Unit. The PNH was evaluated with Ham’s and/or sucrose tests until 1993, when the firsts cytometric analysis of PNH were performed in our …

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Paroxysmal Nocturnal Hemoglobinuria and Magnetic Resonance Imaging

Miguel Pastrana, Cristina Muñoz‐Linares, Emilio Díaz Ojeda, Rafael Forés et autres

Abstract Paroxysmal Nocturnal Hemoglobinuria (PNH) is a rare and complex disease characterized by a severe prothrombotic state caused by a complement system mediated hemolysis. The introduction of the anti-C5 antibody, Eculizumab, has been conducted in many Hematology units worldwide to adopt new …

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Paroxysmal Nocturnal Hemoglobinuria and Thrombosis Before and After Eculizumab

Cristina Muñoz‐Linares, Miguel Pastrana, Emilio Díaz Ojeda, Rafael Forés et autres

Abstract Thrombosis, mainly venous but also arterial, is the leading threat in Paroxysmal Nocturnal Hemoglobinuria (PNH) patients, caused by the continuous hemolysis. It constitutes the first cause of death in all reported series. Since 1964, a total of 56 patients with PNH …

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Pre-Drill WBS Evaluation: Plane of Weakness and Well Design - A Case Study in the South of Mexico

Carlos Pérez Téllez, José Rafael Cabrera, Detlef Balasejus

Abstract Borehole instability mechanisms have been studied in oilwell drilling for many years. Rock behavior has been important because drilling complexity and risk increase accordingly, leading to the need of more complete risk assessments in well design. A new need for risk …

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Analysis of Procoagulants Phospholipids in Plasma of Paroxysmal Nocturnal Hemoglobinuria Patients,Processed in Differents Preanalytic Conditions

Cristina Carbonell Muñoz, Jose Antonio Garcia-Marco, Santiago Gil, Emilio Díaz Ojeda et autres

Abstract Abstract 5258 Background: Paroxysmal Nocturnal Hemoglobinuria (PNH) is an infrequent hematopoietic stem cell disorder characterized by a higher risk of Tromboembolic disease. This complication is associated with hemolysis, Fibrinolysis and platelet activation. The increase in plasma of procoagulants microparticles from platelets …

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