Robert Norman Harden

The Medication Quantification Scale 4.0: An Updated Index Based on Prescribers' Perceptions of the Risk Associated With Chronic Pain Medications

Gwenaëlle De Clifford‐Faugère, Hermine Lore Nguena Nguefack, Marimée Godbout-Parent, Mamadou Aliou Diallo et autres

To quantify risks associated with drug utilization in the real world for the treatment of chronic pain (CP), an index called the Medication Quantification Scale (MQS) was developed in 1992 in the United States and last updated in 2003. This study aimed …

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Randomized controlled study to evaluate the efficacy and safety of soticlestat as adjunctive therapy in adults with complex regional pain syndrome

Stuart H. Ratcliffe, Dimitrios Arkilo, Mahnaz Asgharnejad, Sudipta Bhattacharya et autres

OBJECTIVE: The objective was to investigate the efficacy and safety of soticlestat as adjunctive therapy in participants with complex regional pain syndrome (CRPS). DESIGN: A proof-of-concept phase 2a study, comprising a 15-week randomized, double-blind, placebo-controlled, parallel-group study (part A), and an optional …

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In Memoriam: Dr. Jeffrey Fudin

Rollin M. Gallagher, Chris Herndon, Robert Norman Harden

Our dear friend and colleague Jeffrey Fudin passed away on Friday, May 27, 2022, at age 63. Jeff grew up in Newburgh, New York, and graduated from Newburgh Free Academy and later from the Albany College of Pharmacy, Albany, New York, for …

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Delphi study to define core clinical outcomes for inclusion in a complex regional pain syndrome international research registry and data bank

Alison M. Llewellyn, Lisa Buckle, Sharon Grieve, Frank Birklein et autres

ABSTRACT: Complex regional pain syndrome (CRPS) clinical trials have historically captured a diverse range of outcomes. A minimum set of CRPS patient-reported outcomes has been agreed for inclusion in a future CRPS international clinical research registry and data bank. This study aimed …

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Preoperative Predictors of Complex Regional Pain Syndrome Outcomes in the 6 Months Following Total Knee Arthroplasty

Stephen P. Bruehl, Frederic T. Billings, Sara J. Anderson, Gregory G. Polkowski et autres

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The Need to Elevate Research Rigor Involving Regenerative Agents and Orthobiologics as Pain Treatments

Taylor R. Burnham, Zachary L. McCormick, Robert Norman Harden

We previously addressed the Pain Medicine community regarding the state and future of “Regenerative Medicine” as defined by the National Institutes of Health (NIH) [1]. The NIH characterizes Regenerative Medicine as “the process of creating living, functional tissues to repair or replace …

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Complex Regional Pain Syndrome: Practical Diagnostic and Treatment Guidelines, 5th Edition

Robert Norman Harden, Andreas Göebel, Michael J. Massey, Tolga Suvar et autres

There have been some modest recent advancements in the research of Complex Regional Pain Syndrome, yet the amount and quality of the work in this complicated multifactorial disease remains low (with some notable exceptions; e.g., the recent work on the dorsal root …

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Update from the Editors: Addressing the Needs of Our Authors and Patients

Robert W. Hurley, Robert Norman Harden, Rollin M. Gallagher

Scholarly publication is an essential aspect of the sharing of scientific knowledge and the advancement of health care. Although the method and publication process has changed over many years, Pain Medicine continues to publish premier multidisciplinary scholarship in pain, spine, psychology, and …

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Chronic Pain

Steven P. Stanos, Mark D. Tyburski, Robert Norman Harden

Contributors

Denise M. Ambrosi, Michael T Andary, Karen L. Andrews, Thiru M. Annaswamy et autres

Ketamine Infusion: The Wild Wild West (and East)

Robert Norman Harden

Ketamine (RS-2-[2-chlorophenyl]-2-[methylamino] cyclohexanone) was developed first by Parke-Davis in 1962 and has been used primarily for general anesthesia in human and veterinary medicine. It is a noncompetitive antagonist of the N-methyl-d-aspartate (NMDA) receptor, but has several other actions such as the modulation …

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Publishing Consensus Conference Proceedings: Can We Avoid Missed Opportunities While Effectively Managing Bias?

Robert Norman Harden, Gary M. Reisfield, Rollin M. Gallagher

Every year there are innumerable consensus development conferences on topics related to medical diagnosis and treatment. These meetings, which typically convene multiple experts within a discipline, often involve substantial organization, commitment, and financial expenditure. They are labor-intensive and usually represent a high …

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