Jiannan Liu

Perspective opportunities and challenges in translating dental materials into clinical practice

Yi Ma, Ye Tao, Ling Li, Yongsheng Zhou et autres

The clinical translation of dental materials presents significant opportunities, driven by increasing market demand, supportive regulatory frameworks, and advancements in digital and additive manufacturing technologies. These factors facilitate enhanced personalization, improved biocompatibility, and superior aesthetic and mechanical properties of dental products. However, …

PLCH1 overexpression promotes breast cancer progression and predicts poor prognosis through the ERK1/2-EGR1 axis

Jing Li, Fenge Jiang, Congcong Wang, Ping Xin Sun et autres

Background: Phospholipase C η1 (PLCH1), a member of the phospholipase C superfamily, has been implicated in the development of multiple cancers. However, its specific role in breast cancer progression, its association with clinicopathological features, and its prognostic significance remain unclear. Methods: PLCH1 …

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Promoting cognitive engagement with peer feedback through peer review training: The case of Chinese tertiary-level EFL learners

Jia He, Jun Xia, Chun-Mei Zhang, Jiannan Liu

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Hydrogel-based materials for mandibular reconstruction

Yiwen Zhang, Yilan Sun, Jiacheng Luo, Zilin Wang et autres

Mandibular reconstruction remains a significant clinical challenge due to irregular defect geometries, high functional restoration requirements, and complex oral environments. Traditional vascularized bone grafts, while effective, are limited by donor site complications and poor osseointegration. Hydrogel-based materials have emerged as promising alternatives …

Comparative Analysis of Clinical Efficacy and Safety of Pyrotinib Plus Capecitabine versus Trastuzumab Emtansine (T-DM1) as Second-Line Treatment for HER2-Positive Advanced Breast Cancer: A Retrospective Study

Hao Han, Congcong Wang, Fenge Jiang, Ping Xin Sun et autres

Background: HER2-positive advanced breast cancer poses significant treatment challenges. In China, T-DM1 and pyrotinib are key second-line therapies. A comprehensive evaluation of the comparative efficacy and safety profiles of these therapies is imperative for optimizing therapeutic strategies and enhancing patient outcomes. This …

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Crosstalk Between Plk1 and PTEN in Mitosis Affects Chromosomal Stability

Wei Li, Xianning Wang, Jiannan Liu, Yongjian Hao

The mitotic phase involves the distribution and regulation of genetic material. Defects in gene regulation can lead to serious errors in genetic transmission, such as increased instability of chromosomes, thereby increasing susceptibility to cancer and promoting its development. The maintenance of chromosome …

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Integrated analysis of differential expression profile of miRNA in the uterus of seasonal estrus sheep

Fan Yang, Jiannan Liu, Yongfu La, Ran Di et autres

BACKGROUND: Photoperiod is one of the important factors affecting seasonal estrus of sheep. The importance of the uterus to reproduction is self-evident. However, the uterine molecular mechanisms involved in photoperiodic regulation of seasonal estrus events in sheep remain poorly understood. In recent …

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Genome-wide identification and expression analysis of GRAS transcription factors under cold stress in diploid and triploid Eucalyptus

Jiannan Liu, Hao Chen, Chenhe Li, Kang Du et autres

The GRAS [GRI (Gibberellic Acid Insensitive), RGA (Repressor of GAI-3 mutant), and SCR (Scarecrow)] transcription factors play a pivotal role in the development and stress responses of plants. Eucalyptus is an important fast-growing tree species worldwide, yet its poor cold tolerance limits …

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Fluorescence Labeling to Visualize Low-Expressed Proteins in Zebrafish

Xuepu Jin, Binghuang Zhang, Yu Sun, Junchen Lu et autres

CRISPR/Cas9-mediated knock-in (KI) technology allows for easier fluorescent-protein tagging in zebrafish (Danio rerio), a preferred model organism for in vivo imaging due to its transparency during the early developmental stage. Here, we provide a detailed protocol for performing high-efficiency fluorescence gene KI, …

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Dermatomyositis following resection of thyroid and breast cancer: a case report and literature review

Miaomiao Yang, Jiannan Liu

Background: Dermatomyositis is an idiopathic inflammatory myopathy and occurs as a paraneoplastic syndrome. Here, we report an unusual case of dermatomyositis that developed in a patient after the resection of thyroid cancer and breast cancer. The intercorrelation between dermatomyositis and neoplastic disorders …

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Carbon Dots Reshape Bone Regeneration Niche in Diabetes Through Msc-Macrophage Crosstalk

Zilin Wang, Yige Liu, Nuo Jin, Ruomeng Wang et autres

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Schwann Cell‐Mediated M2 ‐Like Macrophage Polarization in Rhabdomyosarcoma

Guanying Feng, Yibo Guo, Mingtao Chen, Yu Zhang et autres

OBJECTIVE: To investigate the cellular components and immunological characteristics of the head and neck rhabdomyosarcoma (RMS) microenvironment. METHODS: We conducted single-cell transcriptomics to analyze the cellular components of the RMS microenvironment. CellChat was utilized for analyzing intercellular interactions. The cancer genome atlas …

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