H W Sharma

Stockton school-aged children’s exposures to polycyclic aromatic hydrocarbons (PAHs)

H W Sharma, Rosemary Castorina, Tanmayi Amanchi, Charles Perrino et autres

Human exposure to polycyclic aromatic hydrocarbons (PAH) is associated with significant adverse health outcomes, yet the magnitude and temporal trends in environmental concentrations are not well understood. Stockton, California, in the San Joaquin Valley, experiences some of the highest air pollution levels …

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Stockton school-aged children’s exposures to polycyclic aromatic hydrocarbons (PAHs)

H W Sharma, Rosemary Castorina, Tanmayi Amanchi, Charles Perrino et autres

Human exposure to polycyclic aromatic hydrocarbons (PAH) is associated with significant adverse health outcomes, yet the magnitude and temporal trends in environmental concentrations are not well understood. Stockton, California, in the San Joaquin Valley, experiences some of the highest air pollution levels …

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Abstract B011: FOXA1 as a pioneer factor in ERα-DNA interactions and its therapeutic potential in ER+ breast cancer: Insights from ChIP-seq and GWAS in Hispanic populations

H W Sharma, A. Arreola, Frances L. Heredia, Hector L. Franco et autres

Abstract Forkhead box A1 (FOXA1) acts as a pioneer factor for Estrogen Receptor alpha (ERα), playing a crucial role in determining where ERα binds to DNA and regulates gene expression in breast cancer cells. A pioneer factor is a class of transcription …

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Telomerase activity in normal human endothelial cells.

R Hsiao, H W Sharma, Shyam Ramakrishnan, E Keith et autres

Telomerase, a ribonucleoprotein complex, adds hexameric repeats of 5' T T A G G G 3' to the ends of chromosomes called telomeres. Telomerase activity is present in germ cells but not in most somatic cells. An overwhelming majority of cancer cells …

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The NF-kappaB transcription factor in oncogenesis.

H W Sharma, Ramaswamy Narayanan

The NF-kappaB transcription factor complex is a pleiotropic activator that participates in the induction of a wide variety of cellular and viral genes. The active complex is composed of two subunits designated NFKB1 and RelA (formerly called p50 and p65, respectively). Binding …

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Cell cycle-dependent modulation of telomerase activity in tumor cells.

Xuemei Zhu, Rakesh Kumar, Mahitosh Mandal, Nitisha Sharma et autres

Telomerase is a ribonucleoprotein complex that is thought to add telomeric repeats onto the ends of chromosomes during the replicative phase of the cell cycle. We tested this hypothesis by arresting human tumor cell lines at different stages of the cell cycle. …

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Transcription factor decoy approach to decipher the role of NF-kappa B in oncogenesis.

H W Sharma, J R Perez, Kimberly A. Higgins-Sochaski, Ru-Xiu Hsiao et autres

Antisense inhibition of the RelA subunit of NF-kappa B transcription factor (but not the NFKB1 subunit) causes pronounced inhibition of tumor cell growth in vitro and in vivo. Inhibition of either subunit, however, results in inhibition of the heterodimeric NF-kappa B complex …

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A DNA motif present in alpha V integrin promoter exhibits dual binding preference to distinct transcription factors.

H W Sharma, Kimberly A. Higgins-Sochaski, J R Perez, Ramaswamy Narayanan

Antisense inhibition of the RelA subunit but not the NFKB1 subunit of NK-kappa B transcription factor results in a block of cellular adhesion and inhibition of tumor cell growth in vitro and in vivo. Studies aimed at dissecting the molecular mechanism of …

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Multiple Mechanisms May Contribute to the Cellular Anti-Adhesive Effects of Phosphorothioate Oligodeoxynucleotides

Zahangir Khaled, Lyuba Benimetskaya, Rephael Zeltser, Tayyaba Irfan Khan et autres

Phosphorothioate oligodeoxynucleotides complementary to the p65 (Rel A) subunit of the NF-kappaB nuclear transcriptional regulatory factor have been suggested to be sequence specific blockers of cellular adhesion. We studied the effects of Rel A antisense, Rel A sense and other phosphorothioate oligodeoxynucleotides …

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Differentiation of immortal cells inhibits telomerase activity.

H W Sharma, J A Sokoloski, J R Perez, Jean-Yves Maltèse et autres

Telomerase, a ribonucleic acid-protein complex, adds hexameric repeats of 5'-TTAGGG-3' to the ends of mammalian chromosomal DNA (telomeres) to compensate for the progressive loss that occurs with successive rounds of DNA replication. Although somatic cells do not express telomerase, germ cells and …

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Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers.

Annemarie Ziegler, David J. Leffell, Subrahmanyam Kunala, H W Sharma et autres

To identify the sites in the p53 tumor suppressor gene most susceptible to carcinogenic mutation by sunlight, the entire coding region of 27 basal cell carcinomas (BCCs) of the skin was sequenced. Fifty-six percent of tumors contained mutations, and these were UV-like: …

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Lymphokine patterns in carcinoma larynx using skin window technique

H W Sharma, Devi Dayal, Amit Kapoor

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