Annemarie Ziegler

Lebenskompetenz mit LARS & LISA

C. Adam Probst, Tobias Buck, Annemarie Ziegler

Für die Förderung von Lebenskompetenzen stehen zahlreiche, auch wissenschaftlich evaluierte und damit prinzipiell wirksame Programme zur Verfügung. Wie bringt man ein derartiges Programm an der eigenen Schule zum Laufen? Erfahrungen aus einem Pilotversuch in Baden-Württemberg.

Impact of arsenic exposure on clinicopathological characteristics of bladder cancer: A comparative study between patients from an arsenic-exposed region and nonexposed reference sites

Mario Ignacio Fernández, Patricio Valdebenito, Iris S. Delgado, Jorge Segebre et autres

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Adaptation to Extreme Environments in an Admixed Human Population from the Atacama Desert

Lucas Vicuña, Mario Ignacio Fernández, Cecilia Vial, Patricio Valdebenito et autres

Inorganic arsenic (As) is a toxic xenobiotic and carcinogen associated with severe health conditions. The urban population from the Atacama Desert in northern Chile was exposed to extremely high As levels (up to 600 µg/l) in drinking water between 1958 and 1971, …

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OC-0512 Radiochemotherapy and hyperthermia in locally advanced rectal cancer - A prospective phase II trial

Cihan Gani, Ulf Lamprecht, Michael Bitzer, Johanna Gellermann et autres

Teneurins: An Integrative Molecular, Functional, and Biomedical Overview of Their Role in Cancer

Boris Rebolledo‐Jaramillo, Annemarie Ziegler

. Their essential role in development of the central nervous system is conserved throughout species, and evidence supports their involvement in organogenesis of additional tissues. Homophilic and heterophilic interactions between Teneurin paralogues mediate cellular adhesion in crucial processes such as neuronal pathfinding …

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Genomic Analysis on Subjects Exposed to Arsenic Identifies Genetic Risk Variants Associated with Bladder Cancer and Variants Under Recent Adaptive Selection

Mario Ignacio Fernández, Lucas Vicuña, Patricio Valdebenito, Eduardo Vilchis Chaparro et autres

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MP65-03 GENOMIC ANALYSIS ON SUBJECTS EXPOSED TO ARSENIC IDENTIFIES GENETIC RISK VARIANTS ASSOCIATED WITH BLADDER CANCER AND VARIANTS UNDER RECENT ADAPTIVE SELECTION

Mario Ignacio Fernández, Lucas Vicuña, Patricio Valdebenito, Eduardo Vilchis Chaparro et autres

showed that 4N1K-peptide expression was a significant predictor for subsequent metastasis (hazard ratio, HR ¼ 3.90, 95% CI ¼ 1.68e9.07,P ¼ 0.002) and overall survival (HR ¼ 2.43, 95% CI ¼ 1.12e4.86,P ¼ 0.012).CONCLUSIONS: Our results demonstrated that TSP-2 and 4N1K-peptide played …

Identification of a Rare Germline Heterozygous Deletion Involving the Polycistronic miR-17–92 Cluster in Two First-Degree Relatives from a BRCA 1/2 Negative Chilean Family with Familial Breast Cancer: Possible Functional Implications

Tomas de Mayo, Annemarie Ziegler, Sebastián Morales, Lilian Jara

Micro-RNAs (miRNAs) have emerged as novel gene expression regulators. Recent evidence strongly suggests a role for miRNAs in a large variety of cancer-related pathways. Different studies have shown that 18.7 to 37% of all human miRNA genes are clustered. miR-17–92 polycistronic cluster …

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Expression of teneurins is associated with tumor differentiation and patient survival in ovarian cancer

Rebecca Graumann, Gabriella A. Di Capua, Juan Esteban Oyarzún, Marcos A. Vásquez et autres

Teneurins are a family of highly conserved pair-rule proteins involved in morphogenesis and development of the central nervous system. Their function in adult tissues and in disease is largely unknown. Recent evidence suggests a role for dysregulated expression of Teneurins in human …

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Teneurin-4 is frequently expressed in human ovarian carcinomas and is associated with tumor differentiation

Annemarie Ziegler

Identification of a seven glycopeptide signature for malignant pleural mesothelioma in human serum by selected reaction monitoring

Ferdinando Cerciello, Meena Choi, Annalisa Nicastri, Damaris Bausch‐Fluck et autres

BACKGROUND: Serum biomarkers can improve diagnosis and treatment of malignant pleural mesothelioma (MPM). However, the evaluation of potential new serum biomarker candidates is hampered by a lack of assay technologies for their clinical evaluation. Here we followed a hypothesis-driven targeted proteomics strategy …

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Teneurin protein family: An emerging role in human tumorigenesis and drug resistance

Annemarie Ziegler, Alejandro H. Corvalán, Ivan S. Roa, Jorge A. Brañes et autres

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