Carla MC Nascimento

Differential regulation of mitochondrial quality control in skeletal muscle by HZE radiation exposure and partial weightbearing in mice

Carla MC Nascimento, James D. Fluckey, Florence Lima, Brandon R. Macias et autres

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Treatment With Combination Chemotherapy (chop) Causes Deleterious Effects On Muscle Mass In Juvenile Mice

M A Pulido Magaña, Carla MC Nascimento, Jaden M. Wells, Jainil Daredia et autres

Pediatric non-Hodgkin lymphoma (NHL) is a common childhood cancer. While combination chemotherapy (chemo) regimens like CHOP (cyclophosphamide, hydroxydaunorubicin, oncovin, prednisone) have significantly improved survival rates, they often induce adverse side effects. Although muscle atrophy is a well-recognized consequence of cancer therapy, the …

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Pediatric CHOP Chemotherapy Acutely Disrupts Satellite-Cell Dynamics and Blunts Muscle Mass in a Sex-Specific Manner

Jainil Daredia, Marc A Magaña, Carla MC Nascimento, Jaden M. Wells et autres

Abstract Pediatric cancer survival now exceeds 85 percent owing, in part, advances and use of combination chemotherapy treatments such as CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone). Despite its efficacy, CHOP may cause deleterious off-target effects during critical pediatric development periods such as …

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Differential regulation of mitochondrial quality control in skeletal muscle by HZE radiation exposure and partial weightbearing in mice

Carla MC Nascimento, James D. Fluckey, Florence Lima, Brandon R. Macias et autres

Abstract Spaceflight places astronauts under both reduced mechanical loading and ionizing radiation, each of which can compromise skeletal muscle health. We investigated whether 21 days of simulated lunar gravity (one sixth G) with or without a single 0.5 Gy dose of 28 …

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Brief ambulatory reloading elevates muscle protein synthesis but does not prevent disuse atrophy in hindlimb-unloaded rats

Michael P. Wiggs, Carla MC Nascimento, Kevin L. Shimkus, James D. Fluckey

Disuse muscle atrophy remains a major challenge in contexts such as prolonged bed rest or microgravity. Here, we investigated whether brief bouts of ambulatory reloading could attenuate skeletal muscle atrophy caused by five days of hindlimb unloading (HU) in rats. Using a …

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Marker Of Mitochondrial Quality Control In Mice Gastrocnemius Muscle Following Recovery From Cisplatin Chemotherapy Treatment.

Carla MC Nascimento, M A Pulido Magaña, Jaden M. Wells, Cory M. Dungan et autres

BACKGROUND: Cisplatin is a common chemotherapy drug however, its use is associated with notably muscle wasting. Evidence suggests cisplatin-induced atrophy is caused by mitochondrial dysfunction stemming from changes to biogenesis, mitophagy, and fusion and fission, termed mitochondrial quality control. There is a …

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