Shivani Diwakar

Decoding the Penicillin-Binding Proteins with Activity-Based Probes

Erin E. Carlson, Nicholas Sparks, Shivani Diwakar

Conspectus The bacterial cell wall is a complex structure that is primarily composed of peptidoglycan (PG), which provides protection from the environment and structural rigidity for the cell. As such, PG plays an important role in bacterial survival, which has made its …

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kinact/KI Value Determination for Penicillin-Binding Proteins in Live Cells

Joshua D. Shirley, Jacob R. Gillingham, Kelsie M. Nauta, Shivani Diwakar et autres

Penicillin-binding proteins (PBPs) are an essential family of bacterial enzymes that are covalently inhibited by the β-lactam class of antibiotics. PBP inhibition disrupts peptidoglycan biosynthesis, which results in deficient growth and proliferation, and ultimately leads to lysis. IC 50 values are often …

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k inact / K I Value Determination for Penicillin-Binding Proteins in Live Cells

Joshua D. Shirley, Kelsie M. Nauta, Jacob R. Gillingham, Shivani Diwakar et autres

Abstract Penicillin-binding proteins (PBPs) are an essential family of bacterial enzymes that are inhibited by the β-lactam class of antibiotics. PBP inhibition disrupts cell wall biosynthesis, which results in deficient growth and proliferation, and ultimately leads to lysis. IC 50 values are …

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In vitro assessment of the transpeptidase activity of S. pneumoniae PBP2x mutants using Lipid II.

Shivani Diwakar

University of Minnesota M.S. thesis. August 2023. Major: Pharmacology. Advisor: Erin Carlson. 1 computer file (PDF); vi, 37 pages.