Erin E. Carlson

Genetically determined ABO blood group, secretor status, Lewis antigens, and panNEN risk

Samuel O. Antwi, Erin E. Carlson, Kari G. Rabe, Teja Koganti et autres

Pancreatic neuroendocrine neoplasms (panNENs) are rare endocrine malignancies with poorly defined risk factors, in contrast to the more common pancreatic ductal adenocarcinoma (PDAC), for which non-O ABO blood group is a well-established susceptibility marker. To determine whether ABO and related glycosylation markers …

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Phenotypic Effects of a Small Molecule CpxA Phosphatase Inhibitor on Uropathogenic Escherichia coli

Alexis M. Stoorza, Erin E. Carlson, Adam S. Duerfeldt

Patients suffering from Urinary Tract Infections (UTIs) are faced with multidrug resistance and a lack of treatment options. An alternative strategy to traditional bactericidal drug design is to disarm pathogenic bacteria by targeting the regulation of virulence factors. Small-molecule CpxRA phosphatase inhibitor …

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Clinical Outcomes in Patients With Worrisome and High-Risk Pancreatic Cysts: A Prospective Cohort Study

Ankit Chhoda, Erin E. Carlson, William R. Bamlet, Ajit H. Goenka et autres

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Cobalt and nickel ion synergy promotes gene amplification and stable metal resistance in Shewanella oneidensis

A. Gavin, Stephanie L. Mitchell, Erin E. Carlson

ABSTRACT Microbial species are integral in environmental homeostasis and have thus developed diverse strategies to adapt, survive, and proliferate under exogenous stress. The growing demand for nanoscale battery materials has led to increasing environmental concentrations of nanomaterials and their constituent metal ions. …

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Development of binding and activity inhibition assays for the antibiotic resistance-associated protein PhoQ

Hannah Addis, Dawson Blankenship, Erin E. Carlson

Antimicrobial resistant infections present a growing threat to public health and were associated with or directly caused 6 million deaths globally in 2021. This huge death toll highlights the need for novel strategies to address AMR infections. Interfering with the regulation of …

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Development of Covalent Inhibitors for Bacterial Histidine Kinases

Patricia Rodríguez, Conrad A. Fihn, Manibarsha Goswami, Erin E. Carlson

Antivirulence therapies offer an alternative strategy against antimicrobial resistance. We synthesized 2-aminobenzothiazole sulfonyl fluoride analogs to covalently inhibit histidine kinases. In vitro and in cellulo assays also identified lead inhibitors for affinity-based probe development. However, alkyne incorporation reduced bioactivity, emphasizing the challenges …

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Preliminary results from a Genome-Wide Association Study of pancreatic neuroendocrine neoplasms identify novel susceptibility loci

Manuel Gentiluomo, Laufey T. Ámundadóttir, Federico Canzian, Samuel O. Antwi et autres

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Abstract B069: On the development of the Pancreatic Cancer Detection Consortium (PCDC) Prospective Cohorts biobank

Janet E. Olson, Shounak Majumder, Jennifer Brooks, Emily J. Kirsch et autres

Abstract Background: The Pancreatic Cancer Detection Consortium (PCDC) is an NCI-sponsored initiative to improve detection of early-stage pancreatic ductal adenocarcinoma (PDAC). A key strategy in this initiative is to develop prospective, multi-center, longitudinal biospecimen collections from individuals without PDAC who are at …

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Cobalt and nickel ion synergy promotes gene duplication amplification and enables stable metal resistance in Shewanella oneidensis

A. Gavin, Stephanie L. Mitchell, Erin E. Carlson

Abstract Microbial species are integral in environmental homeostasis and have thus developed diverse strategies to adapt, survive, and proliferate under exogenous stress. The growing demand for nanoscale battery materials has led to increasing environmental concentrations of nanomaterials and their constituent metal ions. …

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Risk of Pancreatic Cancer in Glycemically Defined New-Onset Diabetes: A Prospective Cohort Study

Suresh T. Chari, Bechien U. Wu, Camden Lopez, Eva Lustigova et autres

BACKGROUND & AIMS: The increased 3-year incidence of pancreatic cancer after new-onset diabetes observed in retrospective studies needs prospective validation. It is unknown whether incidence varies by race and ethnicity. METHODS: In a prospective, observational study using active real-time surveillance of electronic …

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Decoding the Penicillin-Binding Proteins with Activity-Based Probes

Erin E. Carlson, Nicholas Sparks, Shivani Diwakar

Conspectus The bacterial cell wall is a complex structure that is primarily composed of peptidoglycan (PG), which provides protection from the environment and structural rigidity for the cell. As such, PG plays an important role in bacterial survival, which has made its …

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330: COMPARING PANCREATIC FAT IN INDIVIDUALS WITH AND WITHOUT FAMILIAL AND GENETIC RISK FACTORS FOR PANCREATIC CANCER USING ARTIFICIAL INTELLIGENCE-ENABLED PANCREAS FAT ESTIMATION TOOL

Tom Konikoff, Laurens Janssens, Anup Kumar Mishra, Hiroaki Takahashi et autres