Accès ouvert
2026
article
OpenAlex
Noor Muhammad, Rui Ai, Limin Yang, Yuelong Cui et autres
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss, affecting millions worldwide. Despite extensive research, effective treatments remain limited. Polysaccharides, abundant biological macromolecules derived from natural resources have emerged as promising therapeutic candidates due to their …
cn, pk, us
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Accès ouvert
2026
article
OpenAlex
Rui Ai, Noor Muhammad, Yuelong Cui, Liqiang Wang et autres
Sulfonamides remain important to medicinal and fine-chemical production but conventional aniline precursor routes like Pd-catalysed hydrogenation and Béchamp reductions carry sustainability, safety, and chemoselectivity challenges, especially for N-S bond integrity. This review assesses biocatalytic nitroreduction as a selective alternative for nitro-sulfonamides, focusing …
cn, pk
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Accès ouvert
2025
article
OpenAlex
Shaoting Weng, Shengming Ma, Kaiqi Lian, Mingliang Zhang et autres
Canine Parvovirus (CPV) is a significant pathogen threatening the health of canine worldwide, characterized by high infectivity and fatality rates. A rapid, accurate, and convenient detection method is crucial for early intervention and control of CPV infections. In this study, a novel …
cn
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Accès ouvert
2025
article
OpenAlex
Wei Shen, Zheng Nie, Mengzhu Wang, Haorui Zhang et autres
Exosomes are signaling messengers facilitating intercellular communication by delivering molecular cargo. Here, we observed increased levels of exosomal periostin (POSTN) in the blood plasma of patients with proliferative diabetic retinopathy (PDR). Monocytes contributed to elevated levels of exosomal POSTN, and deletion of …
cn, us, ph
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Accès ouvert
2025
article
OpenAlex
Mingxiong Chen, Yilin Jiang, Hanrui Yu, Haolan Qi et autres
Purpose: We aimed to investigate whether hydrogen sulfide (H2S)-preconditioned mesenchymal stem cells (MSCs) could enhance the anti-ferroptotic effects in a murine model of corneal alkali burn. Methods: MSCs were treated with various concentrations of GYY4137 (an H2S donor) and Western blot was …
cn, ph
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Accès ouvert
2025
article
OpenAlex
An Wang, Zongyuan Li, Yilin Jiang, Mingxiong Chen et autres
Purpose: The purpose of this study was to elucidate the role of the corneal lymphatic Prox1 gene in modulating limbal stem cell stemness and facilitating corneal injury repair. Methods: The limbal Prox1 gene was knocked down by adeno-associated virus (AAV). The alkali …
cn
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Accès ouvert
2023
article
OpenAlex
Jie Wu, Yulei Huang, Hanrui Yu, Kaixiu Li et autres
Neurotrophic keratopathy is a persistent defect of the corneal epithelium, with or without stromal ulceration, due to corneal nerve deficiency caused by a variety of etiologies. The treatment options for neurotrophic keratopathy are limited. In this study, an ophthalmic solution was constructed …
cn, hk
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