Rui Tajiri

Giant cell tumor of bone inhibits osteoblastogenesis via WNT5B

Masaki Shimada, Tomonori Tsuyama, Naoto Yoshimura, Makoto Tateyama et autres

INTRODUCTION: Giant cell tumor of bone (GCTB) induces overproduction of bone-resorbing osteoclasts through receptor activator of nuclear factor kappa B ligand (RANKL), leading to bone resorption and destruction. Consequently, denosumab, a neutralizing antibody against RANKL (a cytokine essential for osteoclast induction), is …

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Identification of factors predictive of contralateral secondary hip fractures in patients after initial hip fracture - A prospective observational study

Shu Takata, Yusuke Uehara, Masaru Uragami, Tatsuki Karasugi et autres

Hip fractures are the most serious osteoporotic fractures, and patients often develop contralateral hip fractures. Various factors are reported as risks for secondary hip fracture, but risk analysis is not yet standardized. We conducted a longitudinal prospective observational study of 1395 hip …

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Bisphosphonates with high bone-resorption-capacity promote osteonecrosis of the jaw development after tooth extraction in mice

Ryuta Kubo, Rui Tajiri, Hideki Nakayama, Takeshi Miyamoto

INTRODUCTION: Medication-Related Osteonecrosis of the Jaw (MRONJ) is a condition marked by osteonecrosis of the jaw bone and other symptoms seen following invasive surgical procedures in patients administered bone-modifying agents. Once disease develops, a patient's ADL levels are significantly compromised. However, the …

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A case of medication-related osteonecrosis of the jaw in a patient treated with the angiogenesis inhibitor ramucirumab

Ryuta Kubo, Kenta Kawahara, Rui Tajiri, Shizuka Morodomi et autres

緒 言 ラムシルマブ (サイラムザ ® ) は血管内皮増殖因子受容体 (vascular endothelial growth factor receptor：以下 VEGFR) -2 に対するモノクローナル抗体であり， 血管内皮増殖因子 (vascular endothelial growth factor：以下 VEGF) -A， C， D， E との結合を阻害する血管新生阻害薬である 1 ) ．本邦では， 切 除不能な進行・再発胃癌， 結腸癌， 直腸癌， 非小細胞肺癌お よび肝細胞癌に適応を有する 2 ) ．抗 VEGF 薬 (ベバシズマブ， ラムシルマブ， …

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Plates made from magnesium alloy with a long period stacking ordered structure promote bone formation in a rabbit fracture model

Kosei Takata, Masaki Yugami, Soichiro Karata, Tatsuki Karasugi et autres

Operative treatment is an option for fractures when the fracture is unstable or the patient wishes to return early to daily life or social activities. Metal plates such as titanium and stainless steel are often used in fracture surgery, but the metal …

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Transthyretin amyloid deposition in ligamentum flavum (LF) is significantly correlated with LF and epidural fat hypertrophy in patients with lumbar spinal stenosis

Kazuya Maeda, Kazuki Sugimoto, Masayoshi Tasaki, Takuya Taniwaki et autres

Lumbar spinal stenosis (LSS) is a degenerative disease characterized by intermittent claudication and numbness in the lower extremities. These symptoms are caused by the compression of nerve tissue in the lumbar spinal canal. Ligamentum flavum (LF) hypertrophy and spinal epidural lipomatosis in …

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A machine learning-based scoring system and ten factors associated with hip fracture occurrence in the elderly

Masaru Uragami, Kozo Matsushita, Yuto Shibata, Shu Takata et autres

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