Zhenpeng Zhang

MINK1 inhibition suppresses triple-negative breast cancer by abrogating ALDOA S39 phosphorylation and reprogramming glucose metabolism

Yunwei Shi, Xiujuan Zhang, 左韬, Jinfang Liu et autres

Triple negative breast cancer (TNBC) represents the most malignant subtype of breast cancer, with heightened invasiveness, frequent recurrence and poor prognosis. Deciphering the molecular mechanisms underlying TNBC pathogenesis and drug resistance is critical for developing precision therapeutics. Through deep-coverage phosphoproteomic profiling of …

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Progress in cancer immunotherapy and immunogenicity optimization strategies based on tumor-specific antigens

SHAO Tong, XU Ping, YU Liyan, Zhenpeng Zhang

Tumor-specific antigen including tumor neoantigens, which are antigens expressed only on the surface of tumor cells and not on normal cells, can stimulate the body's anti-tumor immune response and have great potential for personalized precision treatment. This article reviews the types, screening …

Terahertz vortex radiation source based on Cherenkov wakefields

Zhenpeng Zhang, Zonglin Mao, Xueer Wang, Chengyu Zhang et autres

Vortex electromagnetic fields feature a helical wavefront and carry orbital angular momentum (OAM), offering radiation solutions for communications and imaging. In this paper, we propose a terahertz narrow-band vortex electromagnetic radiation source scheme based on a hollow dielectric cylinder loaded with a …

Simultaneous Improvement in Strength and Electrical Conductivity of Al–Mg–Si–Fe–Cu Alloys by Cryogenic Thermomechanical Treatment

Zhenpeng Zhang, Minqiang Gao, Jiuyang Pei, Changfeng Wang et autres

The increasing demand for high‐strength and high electrical conductivity (EC) aluminum alloys in aerospace and automotive industries makes the simultaneous enhancement of both properties increasingly urgent. This work investigates the improvement in mechanical strength and EC in an Al–Mg–Si–Fe–Cu alloy plate processed …

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Sustainable fabrication of metal-ligand coordinated self-healing conductive organosilicon elastomers for flexible sensor applications

Zhenpeng Zhang, Jiawen He, Zhen He, Lili Sun et autres

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Influence of aliphatic hydrophobic side-chain amino acids on the stability of perovskite quantum dots

Lingzheng Bu, Bo Pan, Ling He, Pei‐Wen Wang et autres

Organic–inorganic hybrid perovskite quantum dots are considered ideal materials for quantum dot light-emitting diodes (QLEDs) due to their outstanding optoelectronic properties. However, stability issues have hindered the commercial application of QLEDs. Reducing surface defects in perovskite quantum dots can enhance their stability …

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Detection and Maturity Classification of Dense Small Lychees Using an Improved Kolmogorov–Arnold Network–Transformer

Zhenpeng Zhang, Yifan Wang, Shanglei Chai, Yibin Tian

Lychee detection and maturity classification are crucial for yield estimation and harvesting. In densely packed lychee clusters with limited training samples, accurately determining ripeness is challenging. This paper proposes a new transformer model incorporating a Kolmogorov-Arnold Network (KAN), termed GhostResNet (GRN)-KAN-Transformer, for …

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Panax notoginseng saponin mitigates glycolysis to regulate macrophage polarization and sphingolipid metabolism via hypoxia-inducible factor-1 to alleviate atherosclerosis

Wanqing Li, Zucheng Shang, Aling Shen, Xinsheng Huang et autres

BACKGROUND: Panax notoginseng saponin (PNS) has shown potent activities in treating patients with atherosclerosis (AS), whereas its immunometabolic mechanism remained unknown. OBJECTIVES: To elucidate the characteristics of metabolomics of AS plaque and identify immunometabolic mechanisms of PNS in treating AS. METHODS: PNS …

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Microstructural evolution and mechanical properties during heat treatment in a squeeze casting Al–Si–Mg–Fe–Cu alloy component

Zhenpeng Zhang, Qi Wei, Minqiang Gao, Huifang Pang et autres

The automotive and communications industries have put forward high requirements for the mechanical properties of squeeze casting Al alloys. Heat treatment and alloying are feasible strategies for regulating the microstructure and properties of alloys. This work investigated the microstructure and mechanical properties …

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Molecular subtyping and therapeutic prediction of hepatocellular carcinoma based on exosome proteomics

Mingsong Mao, Ze Zhang, Yao Zhang, Tao Zuo et autres

Precision medicine increasingly relies on molecular subtyping to guide individualized therapy for hepatocellular carcinoma (HCC), yet conventional tissue biopsies have limited capacity to capture tumor heterogeneity and temporal changes. This study utilized patient-derived xenograft (PDX) models to isolate authentic tumor-derived exosomal proteins, …

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Research Progress of Surfactant-Free Microemulsions: A Review

Yue Wu, Guiyang Liu, Zhenpeng Zhang, Dong Li et autres

Surfactant is usually considered the key component to form microemulsion. surfactant-based microemulsion (SBME) can also be called traditional microemulsion. It has a wide range of applications. It has the advantages of high treatment efficiency and low energy consumption in oily sludge treatment. …

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Recent Advances and Future Perspectives on Heat and Mass Transfer Mechanisms Enhanced by Preformed Porous Media in Vacuum Freeze-Drying of Agricultural and Food Products

Xinkang Hu, Bo Zhang, Xintong Du, Huanhuan Zhang et autres

Preformed porous media (PPM) technology has emerged as a transformative approach to enhance heat and mass transfer in vacuum freeze-drying (VFD) of agricultural and food products. This review systematically analyzes recent advances in PPM research, with particular focus on spray freeze-drying (SFD) …

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