Shigefumi Nakamura

Angiotensin receptors contribute to blood pressure homeostasis in salt-depleted SHR

Shigefumi Nakamura, David B. Averill, Mark C. Chappell, Debra I. Diz et autres

This study evaluated the contribution of angiotensin peptides acting at various receptor subtypes to the arterial pressure and heart rate of adult 9-wk-old male conscious salt-depleted spontaneously hypertensive rats (SHR). Plasma ANG II and ANG I in salt-depleted SHR were elevated sevenfold …

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Evaluation of the presence of oxidized lipoprotein (a) in the serum of hypertensive patients

Shingo Yamada, Ryuichi Morishita, Shigefumi Nakamura, Toshio Ogihara et autres

In an attempt to assay native Lp (a), the anti-Lp (a) monoclonal antibody (161E2) was produced against synthetic antigen (Arg-Asn-Pro-Asp-Val-Ala-Pro). Characteristic properties of this 161E2 monoclonal antibody were identified to have reactivity to oxidative modification (treatment with CuCl22 and lipoxygenase), but to …

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Development of Antibody Against Epitope of Lipoprotein(a) Modified by Oxidation

Shingo Yamada, Ryuichi Morishita, Shigefumi Nakamura, Toshio Ogihara et autres

BACKGROUND: Recently, the biological effects of oxidized lipoprotein(a) [Lp(a)] have been reported to be more potent than Lp(a), the arteriosclerosis-relevant lipoprotein. Thus, investigations with oxidized Lp(a) are expected to provide viewpoints different from the conventional ones based on Lp(a). METHODS AND RESULTS: …

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Gene Therapy for Cardiovascular Disease Using Hepatocyte Growth Factor

Ryuichi Morishita, Motokuni Aoki, Shigefumi Nakamura, Jitsuo Higaki et autres

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Potential Role of Hepatocyte Growth Factor, a Novel Angiogenic Growth Factor, in Peripheral Arterial Disease

Shin-ichiro Hayashi, Ryuichi Morishita, Shigefumi Nakamura, Kei Yamamoto et autres

Background —Although hepatocyte growth factor (HGF), a novel angiogenic growth factor, plays an important role in angiogenesis, regulation of local HGF production under hypoxia has not yet been clarified in vascular smooth muscle cells (VSMC) and endothelial cells (EC). Thus, we have …

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Angiotensinogen Gene–Activating Elements Regulate Blood Pressure in the Brain

Tadahiko Nishii, Atsushi Moriguchi, Ryuichi Morishita, Kazuo Yamada et autres

Although the angiotensinogen gene is a possible candidate as a determinant of hypertension, the molecular mechanisms of tissue angiotensinogen gene regulation have yet to be clarified. We identified essential transcription regulators of angiotensinogen production in the central nervous system using synthetic double-stranded …

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Activation of the Brain Angiotensin System by In Vivo Human Angiotensin-Converting Enzyme Gene Transfer in Rats

Shigefumi Nakamura, Atsushi Moriguchi, Ryuichi Morishita, Kazuo Yamada et autres

The possibility of the brain-specific expression of a component of the renin-angiotensin system was evaluated in the present study. We used the hemagglutinating virus of Japan-liposome complex to transfect human angiotensin-converting enzyme (ACE) cDNA, driven by the cytomegalovirus enhancer and beta-actin promoter, …

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Therapeutic Angiogenesis Induced by Human Recombinant Hepatocyte Growth Factor in Rabbit Hind Limb Ischemia Model as Cytokine Supplement Therapy

Ryuichi Morishita, Shigefumi Nakamura, Shinichiro Hayashi, Yoshiaki Taniyama et autres

Hepatocyte growth factor (HGF) exclusively stimulates the growth of endothelial cells without replication of vascular smooth muscle cells and acts as a survival factor against endothelial cell death. Therefore we hypothesized that a decrease in local vascular HGF might be related to …

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Hepatocyte growth factor as a potential index of complication in diabetes mellitus

Shigefumi Nakamura, Ryuichi Morishita, Atsushi Moriguchi, Yoshikage Yo et autres

OBJECTIVE: Diabetes mellitus (DM), characterized by the premature development of microvascular and macrovascular disease, shows a loss of vasodilatory properties of resistance vessels. However, the mechanisms of endothelial dysfunction in diabetes have not yet been clarified. Hepatocyte growth factor (HGF) in vascular …

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Potential role of hepatocyte growth factor in the maintenance of renal structure: Anti-apoptotic action of HGF on epithelial cells

Yoshikage Yo, Ryuichi Morishita, Shigefumi Nakamura, Naruya Tomita et autres

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IS028 GENE THERAPY OF RESTENOSIS BY IN VIVO GENE TRANSFER OF HUMAN HEPATOCYTE GROWTH FACTOR (HGF) THROUGH THE ACCELATION OF RE-ENDOTHELIALIZATION

Shigefumi Nakamura, Ryuichi Morishita, Atsushi Moriguchi, Naruya Tomita et autres

Functional Analysis of Tissue Renin-Angiotensin System Using “Gain and Loss of Function” Approaches: In Vivo Test of in Vitro Hypothesis

Ryuichi Morishita, Motokuni Aoki, Hidetsugu Matsushita, Shinichiro Hayashi et autres

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