Yoshikage Yo

Subject Index Vol. 76,1997

Toshimitsu Niwa, Y. Vanrenterghem, Piero Stratta, C. Canavese et autres

Author Index Vol. 76,1997

Toshimitsu Niwa, Y. Vanrenterghem, P. Stratta, C. Canavese et autres

Announcement

Toshimitsu Niwa, Y. Vanrenterghem, Piero Stratta, Carlotta Canavese et autres

The Cyclin-Dependent Kinase Inhibitor p21 Limits Murine Mesangial Proliferative Glomerulonephritis

Toshiaki Monkawa, Jeffrey W. Pippin, Yoshikage Yo, Jeffrey B. Kopp et autres

BACKGROUND: Mesangial cell (MC) proliferation underlies increased matrix accumulation in glomerulonephritis (GN), and the resolution of MC proliferation occurs largely through apoptosis. Proliferation and apoptosis are controlled by specific cell cycle proteins, where cyclin-dependent kinase (CDK) inhibitors such as p21 bind target …

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Anti-Mouse Mesangial Cell Serum Induces Acute Glomerulonephropathy in Mice

Yoshikage Yo, Michael Braun, Laura M. C. Barisoni, Hideko Mobaraki et autres

In order to develop a model in mouse similar to anti- Thy-1 nephritis in the rat, we prepared sheep antiserum against SV40-transformed mouse mesangial (MES 13) cells. In vivo, the anti-mouse mesangial cell serum-treated mice showed severe azotemia that peaked at day …

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Nuclear Factor-κB Inhibitors as Potential Novel Anti-Inflammatory Agents for the Treatment of Immune Glomerulonephritis

Óscar López‐Franco, Yusuke Suzuki, Guillermo Sanjuán, Julia Blanco et autres

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Hepatocyte Growth Factor as Cardiovascular Hormone: Role of HGF in the Pathogenesis of Cardiovascular Disease

Ryuichi Morishita, Motokuni Aoki, Yoshikage Yo, Toshio Ogihara

Hepatocyte growth factor (HGF) is a mesenchyme-derived pleiotropic factor which regulates cell growth, cell motility, and morphogenesis of various types of cells, and is thus considered a humoral mediator of epithelial-mesenchymal interactions responsible for morphogenic tissue interactions during embryonic development and organogenesis. …

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Prevention of Renal Damage by Angiotensin II Blockade, Accompanied by Increased Renal Hepatocyte Growth Factor in Experimental Hypertensive Rats

Keiko Matsumoto, Ryuichi Morishita, Atsushi Moriguchi, Naruya Tomita et autres

Hepatocyte growth factor (HGF) is a unique growth factor that has many protective functions against renal damage. Our previous study demonstrated that HGF stimulated the growth of endothelial and epithelial cells without the replication of mesangial cells. Moreover, angiotensin (Ang) II significantly …

Hepatocyte growth factor as a potential index of complication in diabetes mellitus

Shigefumi Nakamura, Ryuichi Morishita, Atsushi Moriguchi, Yoshikage Yo et autres

OBJECTIVE: Diabetes mellitus (DM), characterized by the premature development of microvascular and macrovascular disease, shows a loss of vasodilatory properties of resistance vessels. However, the mechanisms of endothelial dysfunction in diabetes have not yet been clarified. Hepatocyte growth factor (HGF) in vascular …

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Potential role of hepatocyte growth factor in the maintenance of renal structure: Anti-apoptotic action of HGF on epithelial cells

Yoshikage Yo, Ryuichi Morishita, Shigefumi Nakamura, Naruya Tomita et autres

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Molecular mechanisms of impaired stimulation of DNA synthesis in cultured hepatocytes of aged rats

Shoichi Kitano, Timothy W. Fawcett, Yoshikage Yo, George S. Roth

We examined epidermal growth factor (EGF)- and epinephrine-stimulated mitogen-activated protein kinase kinase (MEK) 1 and MEK2 activities, DNA polymerase alpha activity, and EGF-stimulated E2F DNA binding activity in primary cultured hepatocytes from 6- and 24-mo-old rats. MEK stimulation by either EGF or …

A Novel Vascular Modulator, Hepatocyte Growth Factor (HGF), as a Potential Index of the Severity of Hypertension

Shigefumi Nakamura, Atsushi Moriguchi, Ryuichi Morishita, Motokuni Aoki et autres

jp (code pays fourni par la source)