Jyoti Acharya

Azithromycin with or without cefixime for suspected or culture-confirmed uncomplicated typhoid fever in Nepal, Bangladesh, and Pakistan (ACT-South Asia): a double-blind, parallel-group, randomised, placebo-controlled, phase 4 trial

Buddha Basnyat, Sudeep Adhikari, Puja Shrestha, Saraswati Budhathoki et autres

BACKGROUND: WHO recommends azithromycin for uncomplicated typhoid fever treatment. Cefixime is also commonly used, but both drugs have reported failure rates of 10% or more. We hypothesised that combining azithromycin's intracellular activity with the extracellular activity of cefixime could overcome each drugs' …

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Practical insights from implementing a national programme for monitoring appropriateness of antimicrobial prescribing in the South-East Asia Region: experience from the CAPTURA project in Bangladesh, Bhutan, and Nepal

Ron Cheah, Karin Thursky, Jyoti Acharya, Andréia Regina Augusto dos Santos et autres

Objectives: Surveillance of antimicrobial prescribing quality is a core element of national antimicrobial resistance containment strategies. The National Antimicrobial Prescribing Survey (NAPS) programme was implemented in Bangladesh, Bhutan, and Nepal under the Fleming Fund-supported Capturing Data on Antimicrobial Resistance Patterns and Trends …

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Changing pattern of severe manifestations of Plasmodium falciparum and Plasmodium vivax malaria

Jyoti Acharya, Dharmesh Harwani

BACKGROUND & OBJECTIVES: Previously there were reports from all over India about the changing spectrum of severe manifestations of Plasmodium falciparum malaria. Consequently, the present retrospective study was conducted to compare the severity of malaria caused by P. falciparum and P. vivax …

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A nucleophilic non aqueous decontaminant for degradation of chemical warfare agents

Gangavarapu K. Prasad, Virendra Vikram Singh, Lokesh Kumar Pandey, Pushpendra Kumar Sharma et autres

An improved non-aqueous decontaminant has been explored against chemical warfare agents sulfur mustard (HD) and soman (GB). This decontaminant comprises of 2-aminoethanol (30% w/v), dimethylamino ethanol (42% w/v), sodium hydroxide (2% w/v), benzotriazole (1% w/v), and dimethyl sulfoxide (25 %) and it …

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Aloe Vera: A multifaceted ayurvedic herb used in palliative care of oral cancer patients

Jyoti Acharya, Surender Kumar Beniwal, Shankar Lal Jakhar, Niranjana Mohta

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Design, construction and validation of a Plasmodium vivax microarray for the transcriptome profiling of clinical isolates

Pon Arunachalam Boopathi, Amit Kumar Subudhi, Sheetal Middha, Jyoti Acharya et autres

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A cross strain Plasmodium falciparum microarray optimized for the transcriptome analysis of Plasmodium falciparum patient derived isolates

Amit Kumar Subudhi, Pon Arunachalam Boopathi, Sheetal Middha, Jyoti Acharya et autres

Malarial parasite P. falciparum, an apicomplexan protozoan has a 23.3 MB nuclear genome and encodes ~ 5600 transcripts. The genetic diversity of the parasite within and across geographical zones is a challenge to gene expression studies which are essential for understanding of …

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324P Aloe vera: an ancient herb for radiation induced xerostomia and oral fibrosis

Jyoti Acharya, Deepanshi Garg, Ranjan Mathur, S.L. Jakhar et autres

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Disease specific modules and hub genes for intervention strategies: A co-expression network based approach for Plasmodium falciparum clinical isolates

Amit Kumar Subudhi, Pon Arunachalam Boopathi, Isha Pandey, Ramandeep Kaur et autres

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Plasmodium falciparum complicated malaria: Modulation and connectivity between exportome and variant surface antigen gene families

Amit Kumar Subudhi, Pon Arunachalam Boopathi, Isha Pandey, Ramandeep Kohli et autres

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An in vivo transcriptome data set of natural antisense transcripts from Plasmodium falciparum clinical isolates

Amit Kumar Subudhi, Pon Arunachalam Boopathi, Shilpi Garg, Sheetal Middha et autres

Antisense transcription is pervasive among biological systems and one of the products of antisense transcription is natural antisense transcripts (NATs). Emerging evidences suggest that they are key regulators of gene expression. With the discovery of NATs in Plasmodium falciparum, it has been …

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Dataset of natural antisense transcripts in P. vivax clinical isolates derived using custom designed strand-specific microarray

Pon Arunachalam Boopathi, Amit Kumar Subudhi, Shilpi Garg, Sheetal Middha et autres

Natural antisense transcripts (NATs) have been detected in many organisms and shown to regulate gene expression. Similarly, NATs have also been observed in malaria parasites with most studies focused on Plasmodium falciparum. There were no reports on the presence of NATs in …

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