Azithromycin with or without cefixime for suspected or culture-confirmed uncomplicated typhoid fever in Nepal, Bangladesh, and Pakistan (ACT-South Asia): a double-blind, parallel-group, randomised, placebo-controlled, phase 4 trial
Buddha Basnyat, Sudeep Adhikari, Puja Shrestha, Saraswati Budhathoki et autres
BACKGROUND: WHO recommends azithromycin for uncomplicated typhoid fever treatment. Cefixime is also commonly used, but both drugs have reported failure rates of 10% or more. We hypothesised that combining azithromycin's intracellular activity with the extracellular activity of cefixime could overcome each drugs' …
kh, np, bd, pk, vn, gb (code pays fourni par la source)
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The Lancet Infectious Diseases